| IED ID | IndEnz0009000049 |
| Enzyme Type ID | chitinase000049 |
| Protein Name |
Chitinase-like protein 4 Chitinase-3-like protein 4 Secreted protein Ym2 |
| Gene Name | Chil4 Chi3l4 Ym2 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAKLILVTGLAILLNVQLGSSYQLMCYYTSWAKDRPTEGSFKPGNIDPCLCTHLIYAFAGMKNNEITYLSEQDLRDYEALNGLKDRNTELKTLLAIGGWKFGPAPFSSMVSTPQNRQTFIKSVIRFLRQYNFDGLNLDWQYPGSRGSPPKDKHLFSVLVQEMRKAFEEESTLNHIPRLLLTSTGAGFIDVIKSGYKIPELSQSLDYIQVMTYDLHDPKNGYTGENSPLYKSPYDIGKSADLNVDSIITYWKDHGAASEKLIVGFPAYGHTFILSDPSKNGIGDPTVSAGPPGKYTNEQGLLAYFEICTFLNEGATEIFDATQEVPYAYLGNEWVGYDNVRSFKLKAQWLKDNNLGGAVVWPLDMDDFSGSFCHQGRFPLTTTLKRDLNVHSASCKASYRGEL |
| Enzyme Length | 402 |
| Uniprot Accession Number | Q91Z98 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | BINDING 141; /note=Chitooligosaccharide; /evidence=ECO:0000255|PROSITE-ProRule:PRU01258; BINDING 360; /note=Chitooligosaccharide; /evidence=ECO:0000255|PROSITE-ProRule:PRU01258 |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Has low chemotactic activity for eosinophils. May play a role in inflammation and allergy. Has no chitinase activity. {ECO:0000269|PubMed:11553626}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Binding site (2); Chain (1); Disulfide bond (2); Domain (1); Region (3); Sequence conflict (3); Signal peptide (1) |
| Keywords | Cytoplasm;Direct protein sequencing;Disulfide bond;Inflammatory response;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Up-regulated in response to IL4 and IL13 and during the allergic response. {ECO:0000269|PubMed:11553626}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. Cytoplasm. Note=Detected in the cytoplasm of keratinocytes. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000269|PubMed:11553626 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 11141507; 16174095; 16966459; 16984263; 19380786; 20939024; 21267068; 21677750; 23558346; 25294623; 34016714; |
| Motif | |
| Gene Encoded By | |
| Mass | 44,975 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |