| IED ID | IndEnz0009000060 |
| Enzyme Type ID | chitinase000060 |
| Protein Name |
Transmembrane glycoprotein NMB Hematopoietic growth factor inducible neurokinin-1 type |
| Gene Name | GPNMB HGFIN NMB UNQ1725/PRO9925 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MECLYYFLGFLLLAARLPLDAAKRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANSALISVGCLAIFVTVISLLVYKKHKEYNPIENSPGNVVRSKGLSVFLNRAKAVFFPGNQEKDPLLKNQEFKGVS |
| Enzyme Length | 572 |
| Uniprot Accession Number | Q14956 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Could be a melanogenic enzyme. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Compositional bias (2); Domain (1); Glycosylation (12); Modified residue (1); Motif (1); Natural variant (9); Region (1); Sequence conflict (1); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Alternative splicing;Amyloidosis;Cell membrane;Disease variant;Endosome;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | P00533; P00533 |
| Induction | INDUCTION: Up-regulated by G-CSF/CSF3 and M-CSF/CSF1 in bone marrow mononuclear cells, hence up-regulation may be linked to differentiation. {ECO:0000269|PubMed:12609765}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:16489096, ECO:0000269|PubMed:16609006}. Melanosome membrane {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}; Single-pass type I membrane protein {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:29336782}; Single-pass type I membrane protein {ECO:0000305}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}. |
| Modified Residue | MOD_RES 542; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q99P91 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14696968; 15231748; 15684612; 15763343; 17845721; 17951401; 18983539; 19320736; 19350579; 19453261; 19834535; 20056711; 20215530; 20375921; 20379614; 20711474; 21252093; 21389974; 21844952; 21874302; 22014058; 22290289; 22891158; 22912767; 23452376; 23794283; 23924854; 24789918; 24933321; 25010402; 25054912; 25426614; 25594584; 25658639; 25772243; 25889792; 26077887; 26261527; 26581806; 26636434; 26751287; 26771826; 26880751; 26883195; 27132081; 27334625; 27515299; 27836549; 27935101; 28003098; 28104809; 28295306; 28400538; 28443476; 28689015; 29428978; 29441921; 29620278; 29703589; 30149180; 30201759; 30340518; 30400781; 30632601; 30670091; 30793225; 30914799; 30992322; 31043488; 31127873; 31260093; 31315839; 31498430; 31675496; 31701227; 31822499; 32478378; 32728200; 33466390; 33565062; 33687658; 33726823; 34108545; 34207849; 34280359; 34464706; 34542985; 34551863; 34777249; 34800878; 34857772; |
| Motif | MOTIF 64..66; /note=Cell attachment site; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 63,923 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |