| IED ID | IndEnz0009000061 |
| Enzyme Type ID | chitinase000061 |
| Protein Name |
Transmembrane glycoprotein NMB DC-HIL Dendritic cell-associated transmembrane protein Osteoactivin |
| Gene Name | Gpnmb Dchil Hgfin Nmb |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MESLCGVLGFLLLAAGLPLQAAKRFRDVLGHEQYPDHMREHNQLRGWSSDENEWDEHLYPVWRRGDGRWKDSWEGGRVQAVLTSDSPALVGSNITFVVNLVFPRCQKEDANGNIVYEKNCRNDLGLTSDLHVYNWTAGADDGDWEDGTSRSQHLRFPDRRPFPRPHGWKKWSFVYVFHTLGQYFQKLGRCSARVSINTVNLTAGPQVMEVTVFRRYGRAYIPISKVKDVYVITDQIPVFVTMSQKNDRNLSDEIFLRDLPIVFDVLIHDPSHFLNDSAISYKWNFGDNTGLFVSNNHTLNHTYVLNGTFNLNLTVQTAVPGPCPPPSPSTPPPPSTPPSPPPSPLPTLSTPSPSLMPTGYKSMELSDISNENCRINRYGYFRATITIVEGILEVSIMQIADVPMPTPQPANSLMDFTVTCKGATPMEACTIISDPTCQIAQNRVCSPVAVDGLCLLSVRRAFNGSGTYCVNFTLGDDASLALTSTLISIPGKDPDSPLRAVNGVLISIGCLAVLVTMVTILLYKKHKAYKPIGNCPRNTVKGKGLSVLLSHAKAPFFRGDQEKDPLLQDKPRTL |
| Enzyme Length | 574 |
| Uniprot Accession Number | Q99P91 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Could be a melanogenic enzyme. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (1); Domain (1); Glycosylation (11); Modified residue (1); Motif (1); Region (1); Sequence conflict (7); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords | Cell membrane;Endosome;Glycoprotein;Membrane;Phosphoprotein;Reference proteome;Signal;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q14956}. Melanosome membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q14956}. Early endosome membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q14956}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:Q14956}. |
| Modified Residue | MOD_RES 546; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:19144319 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10192392; 10604301; 11178107; 11743578; 12466851; 14696968; 15102471; 15985430; 16100390; 16103918; 16247030; 16332269; 16505033; 16602821; 16827931; 17284525; 17475886; 17608931; 17947650; 18036345; 18049427; 18158332; 18313864; 18381073; 18402690; 18555216; 18983539; 19320736; 19493314; 19794069; 20506259; 20570888; 20709912; 20711474; 20739468; 21029394; 21199938; 21203347; 21267068; 21383504; 21398278; 21677750; 21757588; 21933672; 22056141; 22536365; 22833783; 22891158; 22952717; 23113638; 23159315; 23322566; 23977271; 24194600; 24265122; 24415158; 24458150; 24462663; 24516197; 24936834; 25010402; 25054912; 25118265; 25392504; 25545823; 25655803; 25837253; 25899717; 26442636; 26458492; 26581806; 26599547; 26720474; 26771826; 26880751; 26988030; 27011731; 27072596; 27418600; 27585719; 27626380; 27836549; 27857681; 28148779; 28446616; 28487632; 28684211; 28899684; 28939899; 28973166; 28981549; 29263216; 29370175; 29760184; 29857071; 30097565; 30606613; 31057322; 31369031; 32213628; 32436108; 32450896; 32694855; 33176797; 33986446; 34464706; 34582891; 34608215; 34695452; |
| Motif | MOTIF 558..560; /note=Cell attachment site; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 63,676 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |