| IED ID | IndEnz0009000145 |
| Enzyme Type ID | chitinase000145 |
| Protein Name |
Lysozyme D EC 3.2.1.17 1,4-beta-N-acetylmuramidase D |
| Gene Name | LysD CG9118 |
| Organism | Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly) |
| Enzyme Sequence | MKAFIVLVALACAAPAFGRTMDRCSLAREMSNLGVPRDQLARWACIAEHESSYRTGVVGPENYNGSNDYGIFQINDYYWCAPPSGRFSYNECGLSCNALLTDDITHSVRCAQKVLSQQGWSAWSTWHYCSGWLPSIDDCF |
| Enzyme Length | 140 |
| Uniprot Accession Number | P83972 |
| Absorption | |
| Active Site | ACT_SITE 50; /evidence=ECO:0000255|PROSITE-ProRule:PRU00680; ACT_SITE 68; /evidence=ECO:0000255|PROSITE-ProRule:PRU00680 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; |
| DNA Binding | |
| EC Number | 3.2.1.17 |
| Enzyme Function | FUNCTION: Unlikely to play an active role in the humoral immune defense. May have a function in the digestion of bacteria in the food. {ECO:0000269|PubMed:1588905}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Disulfide bond (4); Domain (1); Erroneous initiation (1); Signal peptide (1) |
| Keywords | Antimicrobial;Bacteriolytic enzyme;Disulfide bond;Glycosidase;Hydrolase;Reference proteome;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000250 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 14749722; 15118106; 15324670; 15695583; 16137842; 17588928; 18334252; 18723886; 18783608; 19171888; 19196346; 22590528; 22851689; 23071443; 23550122; 24670639; 26173873; 27058248; 27357258; 29255259; 30385770; 30892991; 31722958; 34066348; 34253067; 3943132; 8159165; 8765296; 9326575; 9692234; |
| Motif | |
| Gene Encoded By | |
| Mass | 15,636 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |