| IED ID | IndEnz0009000146 |
| Enzyme Type ID | chitinase000146 |
| Protein Name |
Dyslexia-associated protein KIAA0319-like protein Adeno-associated virus receptor AAVR |
| Gene Name | Kiaa0319l AAVR |
| Organism | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Ponginae Pongo Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) |
| Enzyme Sequence | MEKRLGVKPNPASWILSGYYWQTSAKWLRTLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCWAACCQDSACHVFWWLEGMCIQADCSRPQSCRAFRTHSSNSMLMFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSEVVTPIVTQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELPGGPKNVSAQPEIPEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYGTPTPQASFQSTSAPYPVIKELVVSAGDSVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKPEPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSIATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEINTVTCQLNCSDHGHCDSFTKRCICDPFWMENFIKVQLRDGESNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRTGIKQKGLVLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL |
| Enzyme Length | 1049 |
| Uniprot Accession Number | Q5RFR6 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Possible role in axon guidance through interaction with RTN4R. {ECO:0000250|UniProtKB:Q8IZA0}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (1); Chain (1); Compositional bias (1); Domain (6); Glycosylation (3); Modified residue (5); Region (2); Sequence conflict (2); Topological domain (3); Transmembrane (2) |
| Keywords | Alternative splicing;Cell membrane;Glycoprotein;Golgi apparatus;Membrane;Phosphoprotein;Reference proteome;Repeat;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000250|UniProtKB:Q8IZA0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IZA0}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8IZA0}; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q8IZA0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IZA0}. Cell membrane {ECO:0000250|UniProtKB:Q8IZA0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IZA0}. Note=Traffics from the plasma membrane to the trans-Golgi network. {ECO:0000250|UniProtKB:Q8IZA0}. |
| Modified Residue | MOD_RES 974; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q8IZA0; MOD_RES 978; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8IZA0; MOD_RES 1009; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8K135; MOD_RES 1031; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8IZA0; MOD_RES 1037; /note=Phosphothreonine; /evidence=ECO:0000250|UniProtKB:Q8IZA0 |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000250}. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 115,740 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |