| IED ID | IndEnz0009000154 |
| Enzyme Type ID | chitinase000154 |
| Protein Name |
Dyslexia-associated protein KIAA0319-like protein Adeno-associated virus receptor AAVR |
| Gene Name | KIAA0319L AAVR KIAA1837 PP791 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MEKRLGVKPNPASWILSGYYWQTSAKWLRSLYLFYTCFCFSVLWLSTDASESRCQQGKTQFGVGLRSGGENHLWLLEGTPSLQSCWAACCQDSACHVFWWLEGMCIQADCSRPQSCRAFRTHSSNSMLVFLKKFQTADDLGFLPEDDVPHLLGLGWNWASWRQSPPRAALRPAVSSSDQQSLIRKLQKRGSPSDVVTPIVTQHSKVNDSNELGGLTTSGSAEVHKAITISSPLTTDLTAELSGGPKNVSVQPEISEGLATTPSTQQVKSSEKTQIAVPQPVAPSYSYATPTPQASFQSTSAPYPVIKELVVSAGESVQITLPKNEVQLNAYVLQEPPKGETYTYDWQLITHPRDYSGEMEGKHSQILKLSKLTPGLYEFKVIVEGQNAHGEGYVNVTVKPEPRKNRPPIAIVSPQFQEISLPTTSTVIDGSQSTDDDKIVQYHWEELKGPLREEKISEDTAILKLSKLVPGNYTFSLTVVDSDGATNSTTANLTVNKAVDYPPVANAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGKVVEMQGVRTPTLQLSAMQEGDYTYQLTVTDTIGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSSDDQKIISYLWEKTQGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPIAKITGNVVITLPTSTAELDGSKSSDDKGIVSYLWTRDEGSPAAGEVLNHSDHHPILFLSNLVEGTYTFHLKVTDAKGESDTDRTTVEVKPDPRKNNLVEIILDINVSQLTERLKGMFIRQIGVLLGVLDSDIIVQKIQPYTEQSTKMVFFVQNEPPHQIFKGHEVAAMLKSELRKQKADFLIFRALEVNTVTCQLNCSDHGHCDSFTKRCICDPFWMENFIKVQLRDGDSNCEWSVLYVIIATFVIVVALGILSWTVICCCKRQKGKPKRKSKYKILDATDQESLELKPTSRAGIKQKGLLLSSSLMHSESELDSDDAIFTWPDREKGKLLHGQNGSVPNGQTPLKARSPREEIL |
| Enzyme Length | 1049 |
| Uniprot Accession Number | Q8IZA0 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Possible role in axon guidance through interaction with RTN4R. {ECO:0000269|PubMed:20697954}.; FUNCTION: (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system. {ECO:0000269|PubMed:26814968}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Alternative sequence (3); Beta strand (25); Chain (1); Domain (6); Erroneous gene model prediction (1); Erroneous initiation (2); Glycosylation (5); Modified residue (5); Natural variant (2); Region (1); Sequence caution (1); Sequence conflict (5); Topological domain (3); Transmembrane (2) |
| Keywords | 3D-structure;Alternative splicing;Cell membrane;Glycoprotein;Golgi apparatus;Host-virus interaction;Membrane;Phosphoprotein;Reference proteome;Repeat;Transmembrane;Transmembrane helix |
| Interact With | Q9BZR6; Q8IUQ4 |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:26814968}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:26814968}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:26814968}; Multi-pass membrane protein {ECO:0000305}. Note=Traffics from the plasma membrane to the trans-Golgi network. {ECO:0000269|PubMed:26814968}. |
| Modified Residue | MOD_RES 974; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 978; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 1009; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:Q8K135; MOD_RES 1031; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:23186163; MOD_RES 1037; /note=Phosphothreonine; /evidence=ECO:0007744|PubMed:20068231 |
| Post Translational Modification | PTM: N-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20697954}. |
| Signal Peptide | |
| Structure 3D | NMR spectroscopy (1); Electron microscopy (5) |
| Cross Reference PDB | 2YRL; 6IHB; 6JCQ; 6JCS; 6NZ0; 7KPN; |
| Mapped Pubmed ID | 25416956; 26638075; 30742069; 31115336; 31434885; 33218165; |
| Motif | |
| Gene Encoded By | |
| Mass | 115,658 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |