| IED ID |
IndEnz0009000180 |
| Enzyme Type ID |
chitinase000180 |
| Protein Name |
Laminarase-resistance protein LRE1
|
| Gene Name |
LRE1 YCL051W YCL51W |
| Organism |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Fungi
Dikarya
Ascomycota
saccharomyceta
Saccharomycotina (true yeasts)
Saccharomycetes
Saccharomycetales
Saccharomycetaceae
Saccharomyces
Saccharomyces cerevisiae (Baker's yeast)
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
|
| Enzyme Sequence |
MPNTHTQHVQISEPNPVNTLSTPSKRGHRHRRSLAISGDFDFLKQPAAIVNLPPPQAAENCPSTAPTAVSSTLSPIRYNRFPCKTNEDAGTLDLPEPRFYPLSPKNNLQTPSPRFFISEEPSFSSPVKGVPDAIINLDDALKTRPRSFKSHRRSESAPPDLEVMVDKGNCAAGSNSMIKEEEDSLIEPESKNEYYEQKLPTALLSPLRPSLCVSEQAIDVDDSALNGSPTHHNHGMQNANARNSNTFNSLKIKGQKQRYYHYTKQLPLTVGCDSQSPKEQRSAASMTINQAMTPSSLAYTPSKLASTPATPVSFYDSNADINLESDNFPLKDNPRYAKDGYPKKCGNSQLNRVLDSDKRQDFSGESRRRRSGSPISHMQHRNLIDNMKGRRNSNTINSIFNYKSQHYEMPYDDMMKNENINAQSMPFSVNGVNNENSIGGVITRADDAPLQHSVVKSCTPDGKEEMNRLKSNDSNEYSKSEGQIRTNSQLSKDILMGEPGDMVDLSSFVNAQRKASNETGDLVFSLSQDDDALKTFHASNSAATSNESWCISDDALGKQAQDSEVRRKRKSKLGLFRHIFSRK |
| Enzyme Length |
583 |
| Uniprot Accession Number |
P25579 |
| Absorption |
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| Active Site |
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| Activity Regulation |
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| Binding Site |
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| Calcium Binding |
|
| catalytic Activity |
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| DNA Binding |
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| EC Number |
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| Enzyme Function |
FUNCTION: Overexpression affects chitinase expression, cell separation and budding pattern, and increases trehalose accumulation and heat resistance by inhibiting protein kinase CBK1. Overexpression also suppresses temperature-induced hyperosmosensitivity and sensitivity to cell wall degrading enzymes. Overexpression of both LRE1 and PBN1 confers resistance to laminarinase. {ECO:0000269|PubMed:11532139, ECO:0000269|PubMed:11580836}. |
| Temperature Dependency |
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| PH Dependency |
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| Pathway |
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| nucleotide Binding |
|
| Features |
Chain (1); Compositional bias (3); Modified residue (4); Region (3) |
| Keywords |
Phosphoprotein;Protein kinase inhibitor;Reference proteome |
| Interact With |
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| Induction |
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| Subcellular Location |
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| Modified Residue |
MOD_RES 393; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:19779198; MOD_RES 398; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:19779198; MOD_RES 516; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:18407956; MOD_RES 552; /note=Phosphoserine; /evidence=ECO:0007744|PubMed:19779198 |
| Post Translational Modification |
PTM: Phosphorylated by CDC28/CDK1. {ECO:0000269|PubMed:14574415}. |
| Signal Peptide |
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| Structure 3D |
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| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10760132;
11283351;
12702273;
16455487;
17316440;
17559233;
17668044;
19536198;
21179020;
23954433;
24040173;
25411401;
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| Motif |
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| Gene Encoded By |
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| Mass |
64,792 |
| Kinetics |
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| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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