| IED ID | IndEnz0009000196 |
| Enzyme Type ID | chitinase000196 |
| Protein Name |
Chitinase-like mite allergen Der p 18.0101 Allergen Der p 18 Chitinase-like house dust mite allergen Der p 18 Group 18 allergen protein allergen Der p 18.0101 |
| Gene Name | |
| Organism | Dermatophagoides pteronyssinus (European house dust mite) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Acari Acariformes Sarcoptiformes Astigmata Psoroptidia Analgoidea (feather mites) Pyroglyphidae (house-dust mites) Dermatophagoidinae Dermatophagoides Dermatophagoides pteronyssinus (European house dust mite) |
| Enzyme Sequence | MTRLSFTVLIFLAAYFGSNIRPNVATLDPKTVCYYESWVHWRQGDGKMDPEDIDTSLCSHIVYSYFGIDASSHEIKLLDQYLMITLHDMEHFTKHKGNAKAMIAVGGASMSDQFSKTAAVEHYRETFVVSTIDLMTKYGFDGVMIDWSGMQAKDSDNFVKLLDKFDEKFAQTSFVMGVTLPATIASYDNYNIPAISNYVDFMNVLTLDYDGPWAYTVGHASALPEQLKTLEAYNKRGAPRHKMVMAVPFFARTWILEKMDKQDVGDKASGPGPKGQFTQTPGFLSYNELCVQIQAETNAFSITRDHDNTAIYAVYVHDNHAEWISFEDRHTLGDKARNITEQGYGGMSVYTLSNEDVHGVCGDKNPLLHAINSNYFRGIVTEPTVVTVTPVTHTTEHVTDIPGVFHCHQEGFFRDKTYCAKYYECKKGDFGLEQTVHHCPNHSQAFDEVSRTCVDHAKIPGC |
| Enzyme Length | 462 |
| Uniprot Accession Number | Q4JK71 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Probably a non-catalytic chitinase-like protein, which binds to insoluble chitin and enhances the activity of the catalytic chitinases (PubMed:16776685). Has weak chitin-binding activity (PubMed:27548813). {ECO:0000269|PubMed:27548813, ECO:0000305|PubMed:16776685}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (2); Domain (2); Glycosylation (2); Signal peptide (1) |
| Keywords | Allergen;Chitin-binding;Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27548813}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..25; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 52,012 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |