| IED ID |
IndEnz0009000253 |
| Enzyme Type ID |
chitinase000253 |
| Protein Name |
Imaginal disk growth factor 6
|
| Gene Name |
Idgf6 CG5210 |
| Organism |
Drosophila melanogaster (Fruit fly) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Mandibulata
Pancrustacea
Hexapoda
Insecta
Dicondylia
Pterygota (winged insects)
Neoptera
Endopterygota
Diptera
Brachycera
Muscomorpha
Eremoneura
Cyclorrhapha
Schizophora
Acalyptratae
Ephydroidea
Drosophilidae (pomace flies)
Drosophilinae
Drosophilini
Drosophila (fruit flies)
Sophophora
melanogaster group
melanogaster subgroup
Drosophila melanogaster (Fruit fly)
|
| Enzyme Sequence |
MIIKALAIVSLCLASIQASKVGAPQLPKKHLVCYYDSASFVKEGLGKLVIDELEPALQFCDYLVYGYAGIERDSHKAVSLNQQLDLDLGKGLYRTVTRLKRKYPNVKILLSVGGDKDIELDKDAKELPNKYLELLESPTGRTRFVNTVYSLVKTYGFDGLDVAWQFPKNKPKKVHSGIGSLWKGFKKVFSGDSIVDEKSEEHKEQFTALLRDVKNAFRPDNLLLSTTVLPNVNSSLFYDIPAVVNYLDFVNLGTFDFFTPQRNPEVADYAAPIYELSERNPEFNVAAQVKYWLRNNCPASKINVGVATYGRPWKLTDDSGDTGVPPVKDVKDEAPVGGNTQVPGIYSWPEVCALLPNQNNAYLKGANAPLIKVQDPAKRFGSYAYRAADKKGDNGIWVSFEDPDTAADKAGYVRTENLGGVALFDLSYDDFRGLCTNEKYPILRAIKYRLTN |
| Enzyme Length |
452 |
| Uniprot Accession Number |
Q23997 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity). {ECO:0000250}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (2); Domain (1); Glycosylation (1); Natural variant (3); Sequence conflict (1); Signal peptide (1) |
| Keywords |
Chitin-binding;Developmental protein;Direct protein sequencing;Disulfide bond;Glycoprotein;Reference proteome;Secreted;Signal |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18342251, ECO:0000269|PubMed:7875581}. Note=It is transported to target tissues via hemolymph. |
| Modified Residue |
|
| Post Translational Modification |
PTM: Glycosylated. {ECO:0000269|PubMed:7875581}. |
| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000269|PubMed:7875581 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
10462411;
12242232;
12417656;
12626737;
12655063;
12765609;
14734306;
15094375;
15466469;
16163390;
17594485;
17967059;
18342250;
19545586;
20220848;
20813047;
21074052;
21611131;
23071443;
23749451;
23840627;
23944235;
25312911;
25492518;
26526100;
26838602;
26850132;
26896675;
27357258;
27794539;
27894253;
28067623;
28404605;
29167272;
31068592;
31635152;
32770153;
32900993;
33159074;
33748138;
9847235;
|
| Motif |
|
| Gene Encoded By |
|
| Mass |
50,354 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|