| IED ID | IndEnz0009000288 |
| Enzyme Type ID | chitinase000288 |
| Protein Name |
Chitinase 1 EC 3.2.1.14 |
| Gene Name | CHT1 CAALFM_CR00180CA CaO19.7517 |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Candida/Lodderomyces clade Candida Candida albicans (Yeast) Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Enzyme Sequence | MILNLIILLAISIVASASNIAAYWGQNAGGDQQTLGDYCSSSPASIIILSFLDGFPNLSLNFANQCSGTFSSGLAHCSQIGSDIKSCQQQGKTILLSLGGATGNYGFSSDSEAVQFAGTLWNKFGGGKDSERPFDDAIVDGFDFDIENKDQTGYAALATQLRKYFSTGTKSYYLSAAPQCPYPDESVGDLMSQVDLDFAFIQFYNNYCSLNQQFNWNSWSNYARGKSIKLYLGLPGSSSSAGSGFVGLSTVQRVVASIKGDSSFGGISIWDISSAENGGYLNQLHQALSGSGSPAAPSNSYQPNTPLTRTYGGSTATASAYISVGFTAGATHGSTTTNDLLAWIDSLFGSSQSSVQQYATPVQSVTATPQPVAATTTSAPKPTASAFNWFGWFDGTTTSTTLQTVYSTVPADQTVYVTLTTTVGSQMLQSLFDKRDVIAEAKSTNLQICWLLFIPLLALICS |
| Enzyme Length | 462 |
| Uniprot Accession Number | Q5AAH2 |
| Absorption | |
| Active Site | ACT_SITE 147; /note=Proton donor; /evidence=ECO:0000255|PROSITE-ProRule:PRU01258 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.; EC=3.2.1.14; |
| DNA Binding | |
| EC Number | 3.2.1.14 |
| Enzyme Function | FUNCTION: Chitinase involved in the remodeling of chitin in the fungal cell wall. Plays a role in cell separation. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (1); Chain (1); Domain (1); Glycosylation (1); Signal peptide (1) |
| Keywords | Carbohydrate metabolism;Chitin degradation;Chitin-binding;Glycoprotein;Glycosidase;Hydrolase;Polysaccharide degradation;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Transcription is greater during growth of the yeast form as compared to the mycelial form and up-regulated by micafungin treatment. {ECO:0000269|PubMed:20859005}. |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12456000, ECO:0000269|PubMed:20641015}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..17; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,890 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |