| IED ID | IndEnz0009000348 |
| Enzyme Type ID | chitinase000348 |
| Protein Name |
Developmental and secondary metabolism regulator veA Velvet complex subunit A |
| Gene Name | velA PCH_Pc13g13200 |
| Organism | Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Penicillium Penicillium chrysogenum species complex Penicillium rubens Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255) (Penicillium chrysogenum) |
| Enzyme Sequence | MANRPSLMPPHNETEHSVSRITREGKQLTYKLSVMQQPERARACGAGAKSSADRRPVDPPPVVELRIFESDPANDTQKTDITFAYNANFFLYATLETARPIAHGRVGGPQSCPVLTGVPVAGVAYLDRPSQAGYFIFPDLSVRHEGRYRLSFHLYEEIKDAKDADKDSTLPLPNQIPLSATSKPGIPQAFLHFRLEVKSVPFTVYSAKKFPGLATSTSLSRIIAEQGCRVRIRRDVRMRRRGDKRDEDYEFGEERAAAYARSSDRFTTPDRYAASMDRPRSNSNGSNIESPYGFVPPDRRPSAPDYGFQCPQPYQRPMPPAPMSHSQTPSYQSHLSFGSTPSHYPAPHMPPTPPPVAPQGIYSPQHAYAQIRHPSNGSEYEGTPIAYPAPQIPVERGGYPKPPMSSYAMDPPKPNSYMDPRMPEPSLYPSTPNVPVSRPQTPNLPAMPPPKPLSNDYANHVVPSVECTSPGGSGGGGYDNVRGKRMVYQTGPTYGKRSHEDTFGLDDRSMQNGMRPDTEPYPAYRDFSGESRAALMAEMGIQLSYKRANGKIVMKAPPSST |
| Enzyme Length | 561 |
| Uniprot Accession Number | B6H3B2 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (PubMed:20543063). The velvet complex acts as a global regulator for secondary metabolite gene expression (PubMed:22439693). Controls the expression of the penicillin gene cluster (PubMed:20543063, PubMed:22439693). Positively controls the expression of the class V chitinase chiB1 (PubMed:21816879). Positively controls the expression of the transcription factor atfA (PubMed:25557366). Required for cell wall integrity and controls hyphal branching (PubMed:20543063). {ECO:0000269|PubMed:20543063, ECO:0000269|PubMed:21816879, ECO:0000269|PubMed:22439693, ECO:0000269|PubMed:25557366}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (2); Domain (1); Motif (1); Region (5) |
| Keywords | Cytoplasm;Nucleus;Reference proteome;Sporulation;Transcription;Transcription regulation |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20543063, ECO:0000269|PubMed:23264641}. Cytoplasm {ECO:0000250|UniProtKB:C8VTV4}. Note=Enriched in the nucleus in the dark (By similarity). {ECO:0000250|UniProtKB:C8VTV4}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | MOTIF 39..44; /note=Nuclear localization signal; /evidence=ECO:0000250|UniProtKB:C8VTV4 |
| Gene Encoded By | |
| Mass | 61,987 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |