| IED ID | IndEnz0009000356 |
| Enzyme Type ID | chitinase000356 |
| Protein Name |
Polycystic kidney disease protein 1-like 1 PC1-like 1 protein Polycystin-1L1 Protein rikishi |
| Gene Name | Pkd1l1 Rks |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MDVDEDQHAVAVLHHKIQANPELCVSDEQDSCPSDAPKGTARDPESQKPSSPAPWDKNVLNTGSEERLSFINGEPQAPPNWDEGTNSFSNPPPGISHTCNLSASWYHPESSSPLTQHPPRATLVTQPENVEHFAICCFPETDAQALPALGIRVHVASGTALCLLLDFGDNCGAQMRLCTLAGATTVTGYHQYRKEGVYELKAVVHDFHRAEELGPYYVDISHGNVSVFMNSSSIHDSEALSFADSLPQQRGTVVVHCFSSISSYNVSFISQTQVASGQAWCGVTVGYKMQSVSVYTNGTVFAANTNITFVAITEETIPLEFAWYFGENPPVMTTSRSIRRRLSVPQWYRVKVKATSRIGSVVSEPHLIRVQKRIMANRLVSTASALVNANVSFECRLNFGTDVAYLWNFGDDTIELGSSSSSHVYSREGEFTVEVLAFNNVSSTTLRKQLFIVREPCQPPPVKNMGPAKVQIWRSQPLRLGVTFEAAILCNISQGLSYTWSFVSAEMTTVTLPTAVNTRRQTIMLPSYTLECGNYTAIAKVQIKGSMVYSNYCVGVEVRARAPVSVISEGTHIFISTATSTFIILRGAQSYDPDNPGAALRYHWTCTAASSPRWPCFDNSTSYQVDTQAPAISFPAKWLSECCDQFLVTLTVSSRGQNSSQALMFLSTRPDLAFRFVHISWVNFRDISVNWNEEVSLRAVCEDCGDVPDLTYSWDLFLVNATEKSAVEVPFCSTVGLLGALALGTSLKSSKSDLPSNLRAPLTPHSPEPSPTPLGWTALSNLGSISAESTAGGHHVPASGAVAGSGEPMEEYSSLSSLAEEALMTNSSEGSWPSPSSSTDFDDFEAYYSDIQEAVLSLGRQPGTSTNFQEAGPSLSAEESASYGDNLLGPFLHTGRAKPTLMIDWPKALVSQAAFHGYTTSGIMGPAVTIKPFSLSSGKTYVLQASVASKHVLLGKAQLYLTVNQAPQDMSCQVRPHHGMEAYTIFSVFCMSGKPDFHYEFRYRIGNTSSHTLYRGQDTQHYFLLPAGDSSDNYKVIVSTEITDGHGSKVQPCTVAVTVLPRYHGNDCCDKELYNSTLESLSTLRLAGSYMETRNYITMITGILSRLYVESRNTSSCGQWSQIQDVLISSACKVPYTDQEGMMDSIHILRDLISFPNKLSLTSAMCIFKYTKMFLAQGQFSRRLLVDKKLRVEFVLLISGVWEAAKEDARDGDYLQEEGMKIISDMLLACLSDEHQIHVSTGQMEFQTLLHRSPQSSIQNLGFVQVHFPSDLASLHSTTQEATQSSCYISQLMFFMKSPYLGGQVPGQVGGVMIPRLYSCESRRPILRGQLETPVTMEFGEEDYLHKRNPAMFVLLRDEVNVHRFTGLSENSQESLQIHIKFSKPVTRPFPIILLVRFSEKATPSDFLVKRVYFWDEQTVQMYVPAAPWKGANVGYLSLLDADYDRKPPNKYLAGAVNYTVHFQWIQCVFWDKTEWRSEGPYPQPGSSPEKVNCSYHHLAPVSVLRRKLNATLEVSSISEFQSHPHNLLPGIFSAFLLVLYGILVSKSRYVDCHEKKNPGFIFLEEDTLPGYQLYAVVIDTGFRSPVRFTSKVFIVLCGENGCSETKELCCPEKPLFGRNSRHTFILSIPNQLGPLQKIRLWHDSSGSSPCWFISHVMVKELCSGQAWFFSAQCWLAVSKLGGHVLREFFCLSHGLGFWKLFYSKFTEYLEDFHIWLSLYSQPPSRSYLHTQRLAVSFCLLCVYSCLTALVTVRDHQQRPLDVGPTAITLEPFCMALLCTLLACPVAQLLSLLFRCSKEARGDMQASTQWPLRGVKTETPQGHDSSGRPDSRQPSPHPTSDLLPWNDQAWRIAASSSAVVCSPFPMEACSHKHHDLREKSHYSPPSSQAPGSGFEELGSQKSRVCLLWSSSVAWAISGSASLACGLGTGFLGYWFVPAQCMWWLYLLLLSLVCCAFITQPLMICLAALVFAWKRKHDSKFFTESLQDATKGLDLELEEHSRTRVPLSPISYSPDTAEEAERVLATRQRERHLRWAQTPSKAKLRVTGERLRRESIMQAALRDMTTHSIMLLLLLFIAYGRFCPGEISLNHAIRKAFTRKANHSLGDLSSTEDWWDWTLSTLLDELYPERTSARAWGAQPGALGGQCHLIGPPVVKLLKISAGTACTPPRPFSELVEDVLPMHSNDLDLENQNVSPGGPETCGVKKESYMHSLGKTRHEAHAALTALRASKWIDHSTRAMSVHFTLYNPPTQLFTSVILGTECLPSGGLVPSFLVESFRIFYSDSALKYLLMLSELLFLVLNVIHLCFQLWGMTTKGILSYWRKPRHWLELSMVGVAIAYYAASGHLTTLAVNITDQFHKGLYQRLVDIGLMVSWHQRARCLQGILLFLWMLKYVHLLSSLSTMTPFSAVTCFPLFRVLLVGALLLAAHYHSRWFLLFTGTLSHGTSAEAFPGLLLQFPGRSKKDSWHNCLKSDHGVMRCYYGTLFLLLATLGFRMLRATFLTVFQNRKSSHRKPLVTLKDIAVYTWHKVLTLLGLETTLEETEVATDHIYYLDEFSSLLDELLMKIDGLSDSLELSILENQWKRALESRAGDSPPVGSSEYQATGVSGPLAAESE |
| Enzyme Length | 2615 |
| Uniprot Accession Number | Q8R526 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning. {ECO:0000269|PubMed:21307093, ECO:0000269|PubMed:24336289}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (4); Domain (5); Glycosylation (9); Mutagenesis (1); Region (4); Sequence conflict (5); Topological domain (12); Transmembrane (11) |
| Keywords | Calcium;Calcium channel;Calcium transport;Cell membrane;Cell projection;Cilium;Glycoprotein;Ion channel;Ion transport;Membrane;Reference proteome;Repeat;Transmembrane;Transmembrane helix;Transport |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:21307093}; Multi-pass membrane protein {ECO:0000269|PubMed:21307093}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 16141072; 16805797; 18799693; 19322198; 19834762; 21267068; 22008794; 24585447; 25807483; 27272319; |
| Motif | |
| Gene Encoded By | |
| Mass | 290,844 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |