| IED ID |
IndEnz0009000358 |
| Enzyme Type ID |
chitinase000358 |
| Protein Name |
Dyslexia-associated protein KIAA0319
|
| Gene Name |
KIAA0319 |
| Organism |
Homo sapiens (Human) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Mammalia
Theria
Eutheria
Boreoeutheria
Euarchontoglires
Primates
Haplorrhini
Simiiformes
Catarrhini
Hominoidea (apes)
Hominidae (great apes)
Homininae
Homo
Homo sapiens (Human)
|
| Enzyme Sequence |
MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAACCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR |
| Enzyme Length |
1072 |
| Uniprot Accession Number |
Q5VV43 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. {ECO:0000269|PubMed:19679544}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Alternative sequence (3); Beta strand (10); Chain (1); Compositional bias (1); Domain (6); Erroneous initiation (1); Glycosylation (10); Motif (1); Mutagenesis (1); Natural variant (7); Region (3); Sequence conflict (5); Signal peptide (1); Topological domain (2); Transmembrane (1) |
| Keywords |
3D-structure;Alternative splicing;Cell membrane;Developmental protein;Endosome;Glycoprotein;Membrane;Neurogenesis;Reference proteome;Repeat;Signal;Transmembrane;Transmembrane helix |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18063668, ECO:0000269|PubMed:19419997}; Single-pass type I membrane protein {ECO:0000269|PubMed:18063668}. Early endosome membrane {ECO:0000269|PubMed:19419997}; Single-pass type I membrane protein {ECO:0000269|PubMed:18063668}. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted. {ECO:0000269|PubMed:18063668}. |
| Modified Residue |
|
| Post Translational Modification |
PTM: N-glycosylated. {ECO:0000269|PubMed:18063668}.; PTM: O-glycosylated. {ECO:0000269|PubMed:18063668}.; PTM: Shedding of the extracellular domain and intramembrane cleavage produce several proteolytic products. The intramembrane cleavage releases a soluble cytoplasmic polypeptide that translocates to the nucleolus. {ECO:0000269|PubMed:20943657}. |
| Signal Peptide |
SIGNAL 1..20; /evidence=ECO:0000255 |
| Structure 3D |
NMR spectroscopy (1) |
| Cross Reference PDB |
2E7M;
|
| Mapped Pubmed ID |
10535736;
10542231;
10559861;
10559924;
10625686;
10766823;
11071885;
11082044;
11231140;
11239472;
11470803;
11517213;
11532990;
11577110;
11889126;
12057195;
12086608;
12421765;
12952949;
1317852;
14622578;
14622579;
15252009;
15260957;
15318165;
1535555;
15473838;
15502812;
15502813;
15649145;
15703209;
15895077;
16103228;
16215232;
16326391;
16410077;
16516836;
16723738;
16798879;
16903783;
17018281;
17033633;
17158794;
17267500;
17360967;
17450541;
17512409;
17540576;
17597587;
17609109;
17681954;
17713526;
17765681;
17978091;
18032517;
18093523;
18388313;
18790740;
18810304;
18829873;
18981233;
19092055;
19140243;
19296720;
19325871;
19362708;
19458185;
19536138;
19575674;
19588467;
19603039;
19696796;
20033059;
20059951;
20068590;
20231386;
20351096;
20428113;
20448150;
20826345;
20846247;
20946875;
21104116;
21150319;
2115402;
21187331;
21203818;
21207242;
21278753;
21316588;
21445324;
21457949;
21482805;
21613550;
21779028;
21841790;
21927000;
21927001;
21934641;
21962517;
21995445;
22099461;
22233676;
22262880;
22326444;
22505844;
22558177;
2257624;
23065966;
23297414;
23536704;
23677054;
23823722;
23831424;
23861397;
23891661;
24186068;
24430574;
24581490;
24789820;
24966051;
25015435;
25107275;
25230923;
25341920;
25953057;
26042225;
26403691;
27098879;
27312598;
27464509;
27465261;
28074887;
28334068;
28866788;
2890644;
28958754;
29066855;
30742069;
31204720;
3417785;
35031635;
6146630;
7569928;
7877694;
8524399;
8552632;
9092476;
9100026;
9427626;
9428629;
9635431;
9736607;
9812899;
|
| Motif |
MOTIF 995..998; /note=Endocytosis signal |
| Gene Encoded By |
|
| Mass |
117,763 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|