| IED ID | IndEnz0010000049 |
| Enzyme Type ID | esterase000049 |
| Protein Name |
Acyl-coenzyme A thioesterase 8 Acyl-CoA thioesterase 8 EC 3.1.2.1 EC 3.1.2.11 EC 3.1.2.2 EC 3.1.2.3 EC 3.1.2.5 Choloyl-coenzyme A thioesterase EC 3.1.2.27 HIV-Nef-associated acyl-CoA thioesterase Peroxisomal acyl-CoA thioesterase 2 PTE-2 Peroxisomal acyl-coenzyme A thioester hydrolase 1 PTE-1 Peroxisomal long-chain acyl-CoA thioesterase 1 Thioesterase II hACTE-III hACTEIII hTE |
| Gene Name | ACOT8 ACTEIII PTE1 |
| Organism | Homo sapiens (Human) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human) |
| Enzyme Sequence | MSSPQAPEDGQGCGDRGDPPGDLRSVLVTTVLNLEPLDEDLFRGRHYWVPAKRLFGGQIVGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKLPVLYQVERTRTGSSFSVRSVKAVQHGKPIFICQASFQQAQPSPMQHQFSMPTVPPPEELLDCETLIDQYLRDPNLQKRYPLALNRIAAQEVPIEIKPVNPSPLSQLQRMEPKQMFWVRARGYIGEGDMKMHCCVAAYISDYAFLGTALLPHQWQHKVHFMVSLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRQDGVLAVTCAQEGVIRVKPQVSESKL |
| Enzyme Length | 319 |
| Uniprot Accession Number | O14734 |
| Absorption | |
| Active Site | ACT_SITE 232; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 254; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 304; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by CoASH (IC(50)=10-15 uM). Also inhibited by cysteine-reactive agents. {ECO:0000250|UniProtKB:P58137}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=choloyl-CoA + H2O = cholate + CoA + H(+); Xref=Rhea:RHEA:14541, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29747, ChEBI:CHEBI:57287, ChEBI:CHEBI:57373; EC=3.1.2.27; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:14542; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+); Xref=Rhea:RHEA:31511, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:36234, ChEBI:CHEBI:57287, ChEBI:CHEBI:62989; EC=3.1.2.27; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31512; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=acetyl-CoA + H2O = acetate + CoA + H(+); Xref=Rhea:RHEA:20289, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=3.1.2.1; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20290; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=butanoyl-CoA + H2O = butanoate + CoA + H(+); Xref=Rhea:RHEA:40111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17968, ChEBI:CHEBI:57287, ChEBI:CHEBI:57371; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40112; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=2-methylpropanoyl-CoA + H2O = 2-methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:40799, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:48944, ChEBI:CHEBI:57287, ChEBI:CHEBI:57338; Evidence={ECO:0000269|PubMed:10944470};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40800; Evidence={ECO:0000305|PubMed:10944470}; CATALYTIC ACTIVITY: Reaction=H2O + hexanoyl-CoA = CoA + H(+) + hexanoate; Xref=Rhea:RHEA:40115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17120, ChEBI:CHEBI:57287, ChEBI:CHEBI:62620; Evidence={ECO:0000269|PubMed:9153233};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40116; Evidence={ECO:0000305|PubMed:9153233}; CATALYTIC ACTIVITY: Reaction=H2O + octanoyl-CoA = CoA + H(+) + octanoate; Xref=Rhea:RHEA:30143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25646, ChEBI:CHEBI:57287, ChEBI:CHEBI:57386; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30144; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=decanoyl-CoA + H2O = CoA + decanoate + H(+); Xref=Rhea:RHEA:40059, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:27689, ChEBI:CHEBI:57287, ChEBI:CHEBI:61430; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40060; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=dodecanoyl-CoA + H2O = CoA + dodecanoate + H(+); Xref=Rhea:RHEA:30135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:18262, ChEBI:CHEBI:57287, ChEBI:CHEBI:57375; Evidence={ECO:0000269|PubMed:9153233};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30136; Evidence={ECO:0000305|PubMed:9153233}; CATALYTIC ACTIVITY: Reaction=H2O + tetradecanoyl-CoA = CoA + H(+) + tetradecanoate; Xref=Rhea:RHEA:40119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30807, ChEBI:CHEBI:57287, ChEBI:CHEBI:57385; Evidence={ECO:0000269|PubMed:10944470, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40120; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate; Xref=Rhea:RHEA:16645, ChEBI:CHEBI:7896, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57379; EC=3.1.2.2; Evidence={ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16646; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=H2O + octadecanoyl-CoA = CoA + H(+) + octadecanoate; Xref=Rhea:RHEA:30139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:25629, ChEBI:CHEBI:57287, ChEBI:CHEBI:57394; Evidence={ECO:0000269|PubMed:9299485};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30140; Evidence={ECO:0000305|PubMed:9299485}; CATALYTIC ACTIVITY: Reaction=H2O + malonyl-CoA = CoA + H(+) + malonate; Xref=Rhea:RHEA:40219, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15792, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40220; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+); Xref=Rhea:RHEA:15673, ChEBI:CHEBI:13705, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57286, ChEBI:CHEBI:57287; EC=3.1.2.11; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15674; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=H2O + propanoyl-CoA = CoA + H(+) + propanoate; Xref=Rhea:RHEA:40103, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17272, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40104; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=H2O + succinyl-CoA = CoA + H(+) + succinate; Xref=Rhea:RHEA:11516, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30031, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292; EC=3.1.2.3; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:11517; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=glutaryl-CoA + H2O = CoA + glutarate + H(+); Xref=Rhea:RHEA:40575, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30921, ChEBI:CHEBI:57287, ChEBI:CHEBI:57378; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40576; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=H2O + hexanedioyl-CoA = CoA + H(+) + hexanedioate; Xref=Rhea:RHEA:40583, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17128, ChEBI:CHEBI:57287, ChEBI:CHEBI:76327; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40584; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=H2O + octanedioyl-CoA = CoA + H(+) + octanedioate; Xref=Rhea:RHEA:40587, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:76282, ChEBI:CHEBI:76317; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40588; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=decanedioyl-CoA + H2O = CoA + decanedioate + H(+); Xref=Rhea:RHEA:40591, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:76283, ChEBI:CHEBI:76316; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40592; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=dodecanedioyl-CoA + H2O = CoA + dodecanedioate + H(+); Xref=Rhea:RHEA:40595, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:76273, ChEBI:CHEBI:76315; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40596; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=(9Z)-tetradecenoyl-CoA + H2O = (9Z)-tetradecenoate + CoA + H(+); Xref=Rhea:RHEA:40135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32370, ChEBI:CHEBI:57287, ChEBI:CHEBI:65060; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40136; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=(9Z)-hexadecenoyl-CoA + H2O = (9Z)-hexadecenoate + CoA + H(+); Xref=Rhea:RHEA:40131, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32372, ChEBI:CHEBI:57287, ChEBI:CHEBI:61540; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40132; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=(9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+); Xref=Rhea:RHEA:40139, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30823, ChEBI:CHEBI:57287, ChEBI:CHEBI:57387; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40140; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=(9Z,12Z)-octadecadienoyl-CoA + H2O = (9Z,12Z)-octadecadienoate + CoA + H(+); Xref=Rhea:RHEA:40143, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57383; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40144; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=eicosanoyl-CoA + H2O = CoA + eicosanoate + H(+); Xref=Rhea:RHEA:40147, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32360, ChEBI:CHEBI:57287, ChEBI:CHEBI:57380; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40148; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + CoA + H(+); Xref=Rhea:RHEA:40151, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:32395, ChEBI:CHEBI:57287, ChEBI:CHEBI:57368; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40152; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=4,8-dimethylnonanoyl-CoA + H2O = 4,8-dimethylnonanoate + CoA + H(+); Xref=Rhea:RHEA:40223, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061, ChEBI:CHEBI:77063; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40224; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+); Xref=Rhea:RHEA:59952, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:84847, ChEBI:CHEBI:143533; Evidence={ECO:0000250|UniProtKB:Q8VHK0};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59953; Evidence={ECO:0000250|UniProtKB:Q8VHK0}; CATALYTIC ACTIVITY: Reaction=(3S)-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+); Xref=Rhea:RHEA:16305, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17325, ChEBI:CHEBI:43074, ChEBI:CHEBI:57287; EC=3.1.2.5; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16306; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+); Xref=Rhea:RHEA:59936, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:63001, ChEBI:CHEBI:85674; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59937; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+); Xref=Rhea:RHEA:59940, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:143530, ChEBI:CHEBI:143531; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59941; Evidence={ECO:0000250|UniProtKB:P58137}; CATALYTIC ACTIVITY: Reaction=H2O + prostaglandin F2alpha-CoA = CoA + H(+) + prostaglandin F2alpha; Xref=Rhea:RHEA:59948, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57404, ChEBI:CHEBI:143532; Evidence={ECO:0000250|UniProtKB:P58137};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59949; Evidence={ECO:0000250|UniProtKB:P58137}; |
| DNA Binding | |
| EC Number | 3.1.2.1; 3.1.2.11; 3.1.2.2; 3.1.2.3; 3.1.2.5; 3.1.2.27 |
| Enzyme Function | FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:9299485, PubMed:9153233, PubMed:15194431). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (By similarity). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:9299485, PubMed:9153233). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (By similarity). Is also able to hydrolyze CoA esters of dicarboxylic acids (By similarity). It is involved in the metabolic regulation of peroxisome proliferation (PubMed:15194431). {ECO:0000250|UniProtKB:P58137, ECO:0000269|PubMed:15194431, ECO:0000269|PubMed:9153233, ECO:0000269|PubMed:9299485}.; FUNCTION: (Microbial infection) May mediate Nef-induced down-regulation of CD4 cell-surface expression (PubMed:9153233). {ECO:0000269|PubMed:9153233}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:10944470, ECO:0000305|PubMed:9299485}. |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Motif (1); Mutagenesis (1); Region (1); Sequence conflict (2) |
| Keywords | Fatty acid metabolism;Host-virus interaction;Hydrolase;Lipid metabolism;Peroxisome;Peroxisome biogenesis;Reference proteome;Serine esterase |
| Interact With | Q7Z4N8; P50542; Q04864; Q04864-2; P04601 |
| Induction | INDUCTION: Regulated by peroxisome proliferator (such as Clofibrate), via the peroxisome proliferator-activated receptors (PPARs). {ECO:0000250}. |
| Subcellular Location | SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. {ECO:0000269|PubMed:10092594, ECO:0000269|PubMed:15194431}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10022913; 11101887; 11673457; 12456682; 12559034; 12578380; 12885776; 16756494; 16940157; 17007944; 17314511; 18538142; 18712838; 19197237; 19584060; 19632994; 20178365; 21911578; 21976670; 22002062; 22190034; 22747494; 22810585; 23606334; 23963456; 24189400; 24235149; 25416956; 25854684; 26220973; 26496610; 28765278; 28787099; 7719337; 7790377; 8824437; 8858165; 9653144; 9668159; 9837948; |
| Motif | MOTIF 317..319; /note=Microbody targeting signal; /evidence=ECO:0000255 |
| Gene Encoded By | |
| Mass | 35,914 |
| Kinetics | BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=10.1 uM for decanoyl-CoA {ECO:0000269|PubMed:9153233}; Vmax=7.1 umol/min/mg enzyme {ECO:0000269|PubMed:9153233}; |
| Metal Binding | |
| Rhea ID | RHEA:14541; RHEA:14542; RHEA:31511; RHEA:31512; RHEA:20289; RHEA:20290; RHEA:40111; RHEA:40112; RHEA:40799; RHEA:40800; RHEA:40115; RHEA:40116; RHEA:30143; RHEA:30144; RHEA:40059; RHEA:40060; RHEA:30135; RHEA:30136; RHEA:40119; RHEA:40120; RHEA:16645; RHEA:16646; RHEA:30139; RHEA:30140; RHEA:40219; RHEA:40220; RHEA:15673; RHEA:15674; RHEA:40103; RHEA:40104; RHEA:11516; RHEA:11517; RHEA:40575; RHEA:40576; RHEA:40583; RHEA:40584; RHEA:40587; RHEA:40588; RHEA:40591; RHEA:40592; RHEA:40595; RHEA:40596; RHEA:40135; RHEA:40136; RHEA:40131; RHEA:40132; RHEA:40139; RHEA:40140; RHEA:40143; RHEA:40144; RHEA:40147; RHEA:40148; RHEA:40151; RHEA:40152; RHEA:40223; RHEA:40224; RHEA:59952; RHEA:59953; RHEA:16305; RHEA:16306; RHEA:59936; RHEA:59937; RHEA:59940; RHEA:59941; RHEA:59948; RHEA:59949 |
| Cross Reference Brenda | 3.1.2.2;3.1.2.20; |