| IED ID | IndEnz0010000092 |
| Enzyme Type ID | esterase000092 |
| Protein Name |
S-formylglutathione hydrolase FGH EC 3.1.2.12 Esterase D |
| Gene Name | ESD |
| Organism | Bos taurus (Bovine) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Artiodactyla Ruminantia Pecora Bovidae Bovinae Bos (oxen cattle) Bos taurus (Bovine) |
| Enzyme Sequence | MALKQVSSSKCFGGLQKVFEHDSVELKCKMKFAVYLPPKAETGKCPVLYWLSGLTCTEQNFISKSGYHQAASEHGLVVIAPDTSPRGCNIKGEEDSWDFGTGAGFYVDATEDLWKTNYRMYSYVTKELPQLVNDNFPVDPQRMSVFGHSMGGHGALICALKNPGKYKSVSAFAPLCNPVLCRWGKKAFTGYLGTDQSKWEAYDATYLVKSYPGPQLDILIDQGKEDEFLSDGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYLNA |
| Enzyme Length | 282 |
| Uniprot Accession Number | Q08E20 |
| Absorption | |
| Active Site | ACT_SITE 149; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 226; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 260; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H2O + S-formylglutathione = formate + glutathione + H(+); Xref=Rhea:RHEA:14961, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57688, ChEBI:CHEBI:57925; EC=3.1.2.12; |
| DNA Binding | |
| EC Number | 3.1.2.12 |
| Enzyme Function | FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Initiator methionine (1); Modified residue (2) |
| Keywords | Acetylation;Cytoplasm;Cytoplasmic vesicle;Hydrolase;Reference proteome;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle {ECO:0000250}. |
| Modified Residue | MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0000250|UniProtKB:Q9R0P3; MOD_RES 4; /note=N6-succinyllysine; /evidence=ECO:0000250|UniProtKB:Q9R0P3 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 31,548 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:14961 |
| Cross Reference Brenda |