| IED ID | IndEnz0010000094 |
| Enzyme Type ID | esterase000094 |
| Protein Name |
S-formylglutathione hydrolase FGH EC 3.1.2.12 Esterase 10 Esterase D Sid 478 |
| Gene Name | Esd Es10 Sid478 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MALKQISSNRCFGGLQKVFEHSSVELKCKMRFAVYLPPQAESGKCPALYWLSGLTCTEQNFISKSGYQQAASEHGLVVIAPDTSPRGCNIKGEDDSWDFGTGAGFYVNATEDPWKANYRMYSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYRSVSAFAPICNPVLCSWGKKAFSGYLGPDESKWKAYDATCLVKAYSGSQIDILIDQGKDDEFLSNGQLLPDNFIAACTEKKIPVVFRLQEGYDHSYYFIATFIADHIRHHAKYLNA |
| Enzyme Length | 282 |
| Uniprot Accession Number | Q9R0P3 |
| Absorption | |
| Active Site | ACT_SITE 149; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 226; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 260; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=H2O + S-formylglutathione = formate + glutathione + H(+); Xref=Rhea:RHEA:14961, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15740, ChEBI:CHEBI:57688, ChEBI:CHEBI:57925; EC=3.1.2.12; |
| DNA Binding | |
| EC Number | 3.1.2.12 |
| Enzyme Function | FUNCTION: Serine hydrolase involved in the detoxification of formaldehyde. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Erroneous initiation (1); Initiator methionine (1); Modified residue (3); Sequence conflict (1) |
| Keywords | Acetylation;Cytoplasm;Cytoplasmic vesicle;Hydrolase;Reference proteome;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle {ECO:0000250}. |
| Modified Residue | MOD_RES 2; /note=N-acetylalanine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 4; /note=N6-succinyllysine; /evidence=ECO:0007744|PubMed:23806337; MOD_RES 200; /note=N6-acetyllysine; /evidence=ECO:0007744|PubMed:23806337 |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10087289; 11217851; 12466851; 1259699; 1348494; 14610273; 14681479; 15226823; 16602821; 16615898; 1664412; 1765383; 18799693; 18973680; 1914521; 1971251; 198184; 2037301; 2045113; 206412; 21267068; 21311561; 216346; 2164218; 21677750; 2276745; 2307468; 2383242; 2566156; 2570031; 2984788; 3013507; 3081679; 3360305; 3863747; 3925939; 405970; 57899; 6375655; 6980942; 7323947; 7444718; 7601230; 7613031; 7640630; 7772379; 8058779; 8482578; 8672130; 8672132; 869894; 8747923; 9027485; 92985; |
| Motif | |
| Gene Encoded By | |
| Mass | 31,320 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:14961 |
| Cross Reference Brenda |