IED ID | IndEnz0010000121 |
Enzyme Type ID | esterase000121 |
Protein Name |
Acetylcholinesterase-1 AChE EC 3.1.1.7 |
Gene Name | |
Organism | Trittame loki (Brush-footed trapdoor spider) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Araneae (spiders) Mygalomorphae (mygalomorph spiders) Barychelidae Trittame Trittame loki (Brush-footed trapdoor spider) |
Enzyme Sequence | MMLPRCFVTVLLMSSVLYIGGETSSEVLGPVVSTEAGSFQGMELTTHGERVIYAFLGIPYAKPPTGLLRFKKPQPADFIQGTYKATEKPPSCFQLDSDLQLPWADPDSPMKEDCLFLNLWTPASLSTEEEELKSVMVWIHGGGYTSGSSALDVYDGQTLSSSGDVVVVTMNYRLDAFGFLNSLTEDAPGNMALYDQLLALQWVHTNIKYFGGDPNKVTLFGESVGAFATSFLALSPLTKGLFQKIMLESGSAYNKLTVNSIDQAKNNNQLATLVGCANETFTLISNPEEVVACMREVAPAKFTQTYYKELGSEREKINFIFWPHFGDDILPTRTAELIKEKNLTALFAGVNSVEGSALSVFFFPEVYQMFVESNLTLTKAYATILMNEFFKVFNFQDSAKAIEFYLGDVEDDDEEGIRSALFGVVGDYIITCPTIYLADKYSERGANVQFYRFDRRPSTSQWPPEWMGAAHNDEIQFVFGMPVRYPEKYTEEERTLSEYMTRTWTNFVKSEDLKLKNGSQWPSYSLSEPQFATLQTNEQIIGSGQRKAECDFWRPYFDI |
Enzyme Length | 559 |
Uniprot Accession Number | W4VSJ0 |
Absorption | |
Active Site | ACT_SITE 223; /note=Acyl-ester intermediate; /evidence=ECO:0000250; ACT_SITE 354; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 471; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=acetylcholine + H2O = acetate + choline + H(+); Xref=Rhea:RHEA:17561, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089; EC=3.1.1.7; |
DNA Binding | |
EC Number | 3.1.1.7 |
Enzyme Function | FUNCTION: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. {ECO:0000250}. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (3); Modified residue (1); Region (1); Signal peptide (1) |
Keywords | Disulfide bond;Glycoprotein;Hydrolase;Neurotransmitter degradation;Phosphoprotein;Secreted;Serine esterase;Signal |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
Modified Residue | MOD_RES 223; /note=Phosphoserine; /evidence=ECO:0000250 |
Post Translational Modification | |
Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 62,782 |
Kinetics | |
Metal Binding | |
Rhea ID | RHEA:17561 |
Cross Reference Brenda |