Detail Information for IndEnz0010000195
IED ID IndEnz0010000195
Enzyme Type ID esterase000195
Protein Name Abhydrolase domain-containing protein 2
EC 3.1.1.-
Gene Name Hydr2 anon-23D anon-23Da CG3488
Organism Drosophila melanogaster (Fruit fly)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora melanogaster group melanogaster subgroup Drosophila melanogaster (Fruit fly)
Enzyme Sequence MSTAFLTLIAVIVCILFRILNVHSQPLKPSVWCLDAHFLDCLYKIAPVLREPYIPPRLWGFSGHVQTVLHSIVGRVRCPWPLGERVYMSLKDGSTLTYDLYQPLNEQEDDITVAICPGIANSSESVYIRTFVHLAQCNGYRCAVLNHIGALRSVQVTSTRIFTYGHTEDFAAMVEHLHQKYRQSRIVAVGFSLGGNLVTKYMGEDQKTKPDKVIGGISICQGYNAVEGTKWLLNWQNFRRFYLYIMTENVKSIILRHRHILLSDEVKARHNLNEREIIAAATLPELDEAYTRRVYNFPSTQELYKWSSSLFYFDTIKKPMIFINAKDDPLIPEDLLHPIKEYATTRQNTAYVEVAHGGHLGFYEGGFLYPNPVTWLDRTLVAMVGSLVMMHEVGKVAP
Enzyme Length 398
Uniprot Accession Number Q24093
Absorption
Active Site ACT_SITE 192; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 328; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 359; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding
EC Number 3.1.1.-
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Domain (1); Sequence conflict (2); Topological domain (2); Transmembrane (1)
Keywords Hydrolase;Membrane;Reference proteome;Serine esterase;Signal-anchor;Transmembrane;Transmembrane helix
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 10940635; 11035778; 12374736; 12417656; 12958599; 14605208; 15998452; 16825573; 16938865; 17371595; 20220848; 20371351; 20730086; 21074052; 23071443; 23590196; 24058701; 25312911; 28130460; 31095869; 31641108; 31722958; 32598400; 33576571; 33827210; 7768443; 8681796;
Motif
Gene Encoded By
Mass 45,402
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda