IED ID | IndEnz0010000198 |
Enzyme Type ID | esterase000198 |
Protein Name |
Acetylcholinesterase AChE EC 3.1.1.7 Fragment |
Gene Name | ache ace1 |
Organism | Myxine glutinosa (Atlantic hagfish) |
Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Cyclostomata (jawless vertebrates) Myxini Myxiniformes Myxinidae (hagfishes) Myxininae Myxine Myxine glutinosa (Atlantic hagfish) |
Enzyme Sequence | VPSPRPQNATVMVWIFGGGFAYGTSSLNVYDGRYLAQAEGAIVVSMNYRVGALGFLSLPGSPVPGNAGLFDQQLALRWVHGNIHRFGGNPQSVTLFGESAGSASVAPHLLSRHSQQFFQRAILQSGTLNAPWATVEDTEARRRAEALAQALGCPTDDDNELLNCLYARPPQEIVSKEGDVVIEPSIFRFPFVPVVDGHFIIDSPIVLLQQGIFKKTDLLLGVNRNEGSFFLIYGAPGFSKDHESLISREDFLENIPMIVPQGNEVSVDAIVLQYTDWLAQNDALKNRDAIEDIVGDYNVICPVVEMATRYAEFGNNVYFYFFNQRASNLPWPQWMGVI |
Enzyme Length | 338 |
Uniprot Accession Number | Q92081 |
Absorption | |
Active Site | ACT_SITE 99; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 226; /note=Charge relay system; /evidence=ECO:0000250 |
Activity Regulation | |
Binding Site | |
Calcium Binding | |
catalytic Activity | CATALYTIC ACTIVITY: Reaction=acetylcholine + H2O = acetate + choline + H(+); Xref=Rhea:RHEA:17561, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089; EC=3.1.1.7; |
DNA Binding | |
EC Number | 3.1.1.7 |
Enzyme Function | FUNCTION: Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. |
Temperature Dependency | |
PH Dependency | |
Pathway | |
nucleotide Binding | |
Features | Active site (2); Chain (1); Disulfide bond (1); Glycosylation (1); Non-terminal residue (2) |
Keywords | Cell junction;Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Neurotransmitter degradation;Secreted;Serine esterase;Synapse |
Interact With | |
Induction | |
Subcellular Location | SUBCELLULAR LOCATION: Cell junction, synapse. Secreted. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
Modified Residue | |
Post Translational Modification | |
Signal Peptide | |
Structure 3D | |
Cross Reference PDB | - |
Mapped Pubmed ID | - |
Motif | |
Gene Encoded By | |
Mass | 37,300 |
Kinetics | |
Metal Binding | |
Rhea ID | RHEA:17561 |
Cross Reference Brenda |