| IED ID | IndEnz0010000290 |
| Enzyme Type ID | esterase000290 |
| Protein Name |
Acetylcholinesterase 4 AChE 4 EC 3.1.1.7 |
| Gene Name | ace-4 CBG02827 |
| Organism | Caenorhabditis briggsae |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis briggsae |
| Enzyme Sequence | MKPKLVFLPFLIFITVFIEESEAVHPVVLETKLGDIRGNEFFFLSKKIRTFFGVPFAEPPVEEFRFRKPREKKQWKKLFDATKPANACFQTRDNYNTSFWGSEMWNANTQISEDCLYLNIWAPADAYNLTVMVWFFGGGFYSGSPSLSIYDGRALAATQHVIVVNINYRLGPFGFLYLDHPDAPGNMGLLDQQLALHWIRQNIVSFGGNPDKVSVFGQSAGAASIVAHLIAPGSRGLFKNAILQSGSLENTWAINSPFRAKQKSEKLLELVGCNKTTVENSMSCLRLVSPEQLSLSTWNISLTYLEFPFVIVSRDKHFFGHLDARAALREGDFNRDVNLMIGMNKDEGNYWNIYQLPQFFDKAEPPELTRHQFDNLIDSTFSIQPDIIRSAAKYIYSDPNCTDHGRKTRFYAGQMNQIVGDYFFSCDSLWLADQFFLFLQICSTPNGSLKNPPKVFVYYFTQSSSANPWPKWTGAMHGYEIEYVFGVPLSYSKIYKRREQIFSRKIMQFWASFAKNGTPRLRVLKNSEHWPEFNEHNNYRWMQLRSGSNIRPIKRRKETECQFWRRVKDTEYTAYLTQEYSSSCHINSYRILLFIPFFFIFSAF |
| Enzyme Length | 604 |
| Uniprot Accession Number | Q9NDG8 |
| Absorption | |
| Active Site | ACT_SITE 219; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 347; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 477; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=acetylcholine + H2O = acetate + choline + H(+); Xref=Rhea:RHEA:17561, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089; EC=3.1.1.7; |
| DNA Binding | |
| EC Number | 3.1.1.7 |
| Enzyme Function | FUNCTION: Rapidly hydrolyzes choline released into the synapse. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (3); Glycosylation (6); Signal peptide (1) |
| Keywords | Cell junction;Cell membrane;Disulfide bond;Glycoprotein;Hydrolase;Membrane;Neurotransmitter degradation;Reference proteome;Secreted;Serine esterase;Signal;Synapse |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cell junction, synapse {ECO:0000250}. Secreted {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..23; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 69,952 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:17561 |
| Cross Reference Brenda |