| IED ID | IndEnz0010000293 |
| Enzyme Type ID | esterase000293 |
| Protein Name |
Probable O-acetyltransferase CAS1 EC 2.3.1.- Capsule synthesis protein 1 |
| Gene Name | CAS1 CNAG_07937 |
| Organism | Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. grubii (Filobasidiella neoformans var. grubii) Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) |
| Enzyme Sequence | MPNSSNSRSQATAAKLNPLWYTYACATLVAAVVLGNILRWAFLELPDSYHCSALLNTGKWLDPGTWTNWQPEGCFQLPLSAQSWQRCLASPTVNTHQALHSYYDKRTALFVGDSTVRQLYFATARKVGKASKAWESEGEKHTDRSLLVSDPLGGPSLELEFWWDPYLNSSKTIGLLSGRGLAPSSLLVMGSGLWYLRNPSSGGLASWGAMIHDTFEFIKKNQGSPQAALINPWDNMLLGSGLTLPGLLPQQSPKFVDSSREVEARSLFSRASSASHRPADFSISDAIVYLPISTPVHEKLSSSRAETIFHTDVEAMNADLYARLTHPDPPPVVIPSVFNQLLVDDETEDGLHFSDKIMDKQAELLLSWRCNDVMRHEGATGACCKRYDWVTPIQGLILAVLILWAPLGTFITPRLPPNSPIHDYLPSPSIAPALSTFGLAVGYLFLADRTHVFQKEQKDYDAVVFGVITFAAFVAGLLTIKNSGKDLGFLNRDITDEWKGWMQIAILIYHFFGASKISGIYNPIRVLVASYLFMTGYGHFFFYYKKADFGFQRVVMVLVRLNLLSVVLPYTMNTDYAFYYFAPLVSWWYLIIYATMAFGSKYNDRPAFLLAKLFTCAGLVTLFMHFPWLMEDVFKVLNTVFNIQWSAKEWSFRVTLDLFIVWAGMLCAYGFVKFKEYQISDRPWFPTMHTATLIGSVLGMIWYFWFELHLANKFVYNEYHAVVCIVPIISFIFLRNASPVLRSSTSKIFCFIGQCSLETFILQFHGWLASDTKAVLLAVPSTQWRPVNLVISTICFIWLSYRVSGATGEITEWLVGKKKALPLPATSAGPSTSTSRQATSPTLTTASAMQAVVEGPQDGAKGGIPESIPMMNQADKDIGGLTPMEDETLERRDSWPTWMASTAASLTGRTAEGYAPLTRQWKDQTVLSVIQNLGDLMKKHTSVKIAVILFGLWVLNWIY |
| Enzyme Length | 959 |
| Uniprot Accession Number | Q8X226 |
| Absorption | |
| Active Site | ACT_SITE 114; /note=Acyl-ester intermediate; /evidence=ECO:0000250|UniProtKB:Q96PB1; ACT_SITE 349; /evidence=ECO:0000250|UniProtKB:Q96PB1; ACT_SITE 352; /evidence=ECO:0000250|UniProtKB:Q96PB1 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 2.3.1.- |
| Enzyme Function | FUNCTION: Probable O-acetyltransferase required for the O-acetylation of the capsular glucoronoxylmannans (GXM) involved in virulence. {ECO:0000250|UniProtKB:P0CM56}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Glycosylation (2); Transmembrane (13) |
| Keywords | Glycoprotein;Membrane;Oxidoreductase;Transferase;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 107,298 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |