| IED ID | IndEnz0010000383 |
| Enzyme Type ID | esterase000383 |
| Protein Name |
Cholinesterase EC 3.1.1.8 Acylcholine acylhydrolase Butyrylcholine esterase Choline esterase II Pseudocholinesterase |
| Gene Name | BCHE |
| Organism | Oryctolagus cuniculus (Rabbit) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Lagomorpha Leporidae (rabbits and hares) Oryctolagus Oryctolagus cuniculus (Rabbit) |
| Enzyme Sequence | MVTRSSHTEDVIITTKNGRIRGINLPVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPTPKPKNATVMIWIYGGGFQTGTSSLQVYDGKFLTRVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPRSHPLFTRAILQSGSSNAPWEVMSLHEARNRTLTLAKFVGCSTENETEIIKCLRNKDAQEILLNEVFVVPFDSLLSVNFGPTVDGDFLTDMPDTLLQLGQLKKTQILVGVNKDEGTAFLVYGAPGFSKDNTSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDEQRPENYREALDDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTKAEEILSRSIMKRWANFAKYGNPNGTQNNSTRWPVFKSTEQKYLTLNTESPRIYTKLRAQQCRFWTLFFPKVLEMTGNIDEAEQEWKAGFHRWNNYMMAWKNHFNDYTSKKERCAGF |
| Enzyme Length | 581 |
| Uniprot Accession Number | P21927 |
| Absorption | |
| Active Site | ACT_SITE 205; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 332; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 445; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=an acylcholine + H2O = a carboxylate + choline + H(+); Xref=Rhea:RHEA:21964, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:35287; EC=3.1.1.8; |
| DNA Binding | |
| EC Number | 3.1.1.8 |
| Enzyme Function | FUNCTION: Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (4); Glycosylation (9); Modified residue (1); Region (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Phosphoprotein;Reference proteome;Secreted;Serine esterase;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250}. |
| Modified Residue | MOD_RES 205; /note=Phosphoserine; /evidence=ECO:0000250|UniProtKB:P06276 |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..8; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 66,156 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:21964 |
| Cross Reference Brenda |