| IED ID | IndEnz0010000437 |
| Enzyme Type ID | esterase000437 |
| Protein Name |
Protein phosphatase methylesterase 1 PME-1 EC 3.1.1.89 |
| Gene Name | PPE1 AGR359C |
| Organism | Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Eremothecium Eremothecium gossypii (Yeast) (Ashbya gossypii) Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii) |
| Enzyme Sequence | MANNLQKQLFAKKFKDAEEVLRTMDDQGNDAAPDTESDDLGELPAFGCGGIRPRRHASSMPVGDNDSWRKYFAVNEMFAIPERNFKFNTYYKLPQTTNAASIPVFIMHHGAGSSGLTFAPLADELYTRLEGKCGIFSFDARGHGETVPLDSTLEVPYDLATFTADFNAVIKTLQQRILQHKIPKEKLSIVLLGHSLGGSICTTAFNAMESALRSKVVGVAIFDIVEEAAIAALNNMSHHLATTPTSFATMREAIEYYIEKGLSNLRSSAEVCVPALFHKTSRGKAVRITDLASFQKYWHTWFVGLSSRFVHLPTSKLLVLAGSDNLDKELIIGQMQGKYQLVVFQESGHFIQEDAPAKAAITLIEFWRRNDNKNVVIKTNWGQWN |
| Enzyme Length | 385 |
| Uniprot Accession Number | Q74Z47 |
| Absorption | |
| Active Site | ACT_SITE 195; /evidence=ECO:0000250; ACT_SITE 223; /evidence=ECO:0000250; ACT_SITE 349; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; |
| DNA Binding | |
| EC Number | 3.1.1.89 |
| Enzyme Function | FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1) |
| Keywords | Hydrolase;Reference proteome;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 42,841 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:48548 |
| Cross Reference Brenda |