| IED ID | IndEnz0010000439 |
| Enzyme Type ID | esterase000439 |
| Protein Name |
Protein phosphatase methylesterase 1 PME-1 EC 3.1.1.89 |
| Gene Name | PPE1 FGRRES_00587 FGSG_00587 |
| Organism | Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta sordariomyceta Sordariomycetes Hypocreomycetidae Hypocreales Nectriaceae Fusarium Fusarium sambucinum species complex Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum) Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) (Wheat head blight fungus) (Fusarium graminearum) |
| Enzyme Sequence | MSDLQRTWAKAKFGASNDPFDEPQEEQGQDVLPELPEPVDDDSSSASSASSVSSTGTIIPSPNQKLFARPQGVARGRTLEQIPWTTYFEREVSLKSEQDPEVIYHAYLTSPVGKGPLFVMHHGAGSSGLSFAVVASQIRKRISTAGILALDCRGHGSTYAPEDKAFDMRLDTLSSDLYNVVQLTKTEMSWPEMPPIVLVGHSLGGAVVTDLAKSGKLGTSVLGYAVLDVVEGSAIDALQSMHTYLSTRPLGFATLQAGIEWHIRSRTIRNSISARTSVPALLVFNENDDPTRPWRWRTNLGATQPYWEDWFVGLSKKFLEARGGKMLLLAGTDRLDTELTIGQMQGKYALQVFPEAGHFIHEDLPEKTAVSLVDFFRRNDRTALVLPPKVSDLIKQGKRV |
| Enzyme Length | 400 |
| Uniprot Accession Number | Q4IQC1 |
| Absorption | |
| Active Site | ACT_SITE 202; /evidence=ECO:0000250; ACT_SITE 228; /evidence=ECO:0000250; ACT_SITE 358; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; |
| DNA Binding | |
| EC Number | 3.1.1.89 |
| Enzyme Function | FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Region (1) |
| Keywords | Hydrolase;Reference proteome;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 43,956 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:48548 |
| Cross Reference Brenda |