| IED ID | IndEnz0010000462 |
| Enzyme Type ID | esterase000462 |
| Protein Name |
Protein phosphatase methylesterase 1 PME-1 EC 3.1.1.89 |
| Gene Name | ppe1 AN0293 |
| Organism | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Nidulantes Emericella nidulans (Aspergillus nidulans) Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
| Enzyme Sequence | MSDLQKSFAKSKLAKLPPEPPPIPESVADEDDDSGSSTETVTPSPVKQLFARPGGTRGFFDQELYLQRRVNDLDIVHHVYLTSPTNSGPLFVMHHGAGSSGLSFANCAAEIRKILPNAGILSADARDHGSTSVKRASEDGEADPETARLDLSLDTLNQDLLFVIRETQAKMGWETLPDIVLVGHSLGGAVITDVAKKGELGGKLLAYAVLDVVEGSAMDALQSMETYLSTRPSRFPSLPSGIEWHTRSRTIRNRTSARVSVPSLLYHEDVPKDPSKPWVWRTNLAETKPFWEGWFVGLSRKFLEARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVFPDAGHFIQEDQPARTAQILVDFYKRNDRSALVLPPKVADMQASAAMKKGAGAGVPLGKAEGGTTGSFKRS |
| Enzyme Length | 407 |
| Uniprot Accession Number | Q5BGN7 |
| Absorption | |
| Active Site | ACT_SITE 185; /evidence=ECO:0000250; ACT_SITE 211; /evidence=ECO:0000250; ACT_SITE 342; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; |
| DNA Binding | |
| EC Number | 3.1.1.89 |
| Enzyme Function | FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Erroneous gene model prediction (1); Region (2) |
| Keywords | Hydrolase;Reference proteome;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 44,304 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:48548 |
| Cross Reference Brenda |