| IED ID |
IndEnz0010000540 |
| Enzyme Type ID |
esterase000540 |
| Protein Name |
Probable ligand-gated ion channel 46
|
| Gene Name |
lgc-46 Y71D11A.5 |
| Organism |
Caenorhabditis elegans |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Nematoda (roundworms)
Chromadorea
Rhabditida
Rhabditina
Rhabditomorpha
Rhabditoidea
Rhabditidae
Peloderinae
Caenorhabditis
Caenorhabditis elegans
|
| Enzyme Sequence |
MQYLQFLSLVVLLLMCHARKSVYRRNSPSLRRLTRNYDWEVDEHGGLKPIINPAKVERATKNCANDSFILGTIMSNYNRHKIPGGQVDVEVEVWVQEITTISDITSDFQLDIYIYETWYDPALNYAFMNPCKYNLSLNSVLLEKLWTPNSCFINSKTADIHKSPFPNIFLMIYANGTVWTNYRLKLQGPCIMDLTKFPFDNVTCSLTFESFNYNTDEVKMDWSVNGVQKMRDKMELADYELVDIHKIRTTEEYPAGYWHELTMSFEFKRRAGWYILQAYLPTYLTICISWISFALGSKAIPARTMLGVNSLLAMTFQFGNIIRNLPRVSYVKAIDVWMLSCMTFVFCSLLELAWVGYLSREEEPTSAKCLQPSAQVAPKPCHPPPVQQNANNSSVHRRQKQPKNEEESALLSLRDNDYGYIPPGFGLNGNVANAMKSFSSSCSCEPTNVVNLMLDEAETIPTSTSSSLSRKQRREILAHKIDSVSVFMFPFLFVLFNIAYWQHYLRGY |
| Enzyme Length |
508 |
| Uniprot Accession Number |
Q95Y52 |
| Absorption |
|
| Active Site |
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| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Probable component of a ligand-gated anion channel. Negatively regulates synaptic transmission and synaptic vesicle release in response to acetylcholine in cholinergic motor neurons. Role in synaptic vesicle release kinetics may be in association with the ligand-gated ion channel protein acc-4. {ECO:0000269|PubMed:27782882}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Disulfide bond (1); Glycosylation (4); Mutagenesis (2); Region (1); Signal peptide (1); Topological domain (5); Transmembrane (4) |
| Keywords |
Cell junction;Cell membrane;Cell projection;Cytoplasmic vesicle;Disulfide bond;Glycoprotein;Ion channel;Ion transport;Ligand-gated ion channel;Membrane;Reference proteome;Signal;Synapse;Transmembrane;Transmembrane helix;Transport |
| Interact With |
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| Induction |
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| Subcellular Location |
SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane {ECO:0000269|PubMed:27782882}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:27782882}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:27782882}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
12097347;
12529635;
14551910;
15177025;
17612406;
17704769;
20439776;
20610404;
21085631;
21177967;
21367940;
21529718;
21642964;
22286215;
22560298;
22901814;
23800452;
25487147;
28317880;
|
| Motif |
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| Gene Encoded By |
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| Mass |
58,461 |
| Kinetics |
|
| Metal Binding |
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| Rhea ID |
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| Cross Reference Brenda |
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