| IED ID | IndEnz0010000552 |
| Enzyme Type ID | esterase000552 |
| Protein Name |
Lysozyme C, milk isozyme EC 3.2.1.17 1,4-beta-N-acetylmuramidase C |
| Gene Name | |
| Organism | Canis lupus familiaris (Dog) (Canis familiaris) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Laurasiatheria Carnivora Caniformia Canidae (dog coyote wolf fox) Canis Canis lupus (Gray wolf) Canis lupus familiaris (Dog) (Canis familiaris) |
| Enzyme Sequence | KIFSKCELARKLKSMGMDGFHGYSLANWVCMAEYESNFNTQAFNGRNSNGSSDYGIFQLNSKWWCKSNSHSSANACNIMCSKFLDDNIDDDIACAKRVVKDPNGMSAWVAWVKHCKGKDLSKYLASCNL |
| Enzyme Length | 129 |
| Uniprot Accession Number | P81708 |
| Absorption | |
| Active Site | ACT_SITE 35; /evidence=ECO:0000255|PROSITE-ProRule:PRU00680; ACT_SITE 53; /evidence=ECO:0000255|PROSITE-ProRule:PRU00680 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; |
| DNA Binding | |
| EC Number | 3.2.1.17 |
| Enzyme Function | FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. {ECO:0000255|PROSITE-ProRule:PRU00680}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Beta strand (5); Chain (1); Disulfide bond (4); Domain (1); Helix (6); Metal binding (5); Turn (4) |
| Keywords | 3D-structure;Antimicrobial;Bacteriolytic enzyme;Calcium;Direct protein sequencing;Disulfide bond;Glycosidase;Hydrolase;Metal-binding;Milk protein;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (4); NMR spectroscopy (1) |
| Cross Reference PDB | 1EL1; 1I56; 1QQY; 2CWI; 2Z2E; |
| Mapped Pubmed ID | 18214981; |
| Motif | |
| Gene Encoded By | |
| Mass | 14,471 |
| Kinetics | |
| Metal Binding | METAL 82; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0007744|PDB:1EL1; METAL 85; /note=Calcium; /evidence=ECO:0007744|PDB:1EL1; METAL 87; /note=Calcium; via carbonyl oxygen; /evidence=ECO:0007744|PDB:1EL1; METAL 90; /note=Calcium; /evidence=ECO:0007744|PDB:1EL1; METAL 91; /note=Calcium; /evidence=ECO:0007744|PDB:1EL1 |
| Rhea ID | |
| Cross Reference Brenda |