Detail Information for IndEnz0010000581
IED ID IndEnz0010000581
Enzyme Type ID esterase000581
Protein Name Lysozyme C
EC 3.2.1.17
1,4-beta-N-acetylmuramidase C
Allergen Gal d IV
allergen Gal d 4
Gene Name LYZ
Organism Gallus gallus (Chicken)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Archelosauria Archosauria Dinosauria Saurischia Theropoda Coelurosauria Aves Neognathae Galloanserae Galliformes Phasianidae (turkeys) Phasianinae Gallus Gallus gallus (Chicken)
Enzyme Sequence MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL
Enzyme Length 147
Uniprot Accession Number P00698
Absorption
Active Site ACT_SITE 53; ACT_SITE 70
Activity Regulation
Binding Site BINDING 119; /note=Substrate
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17;
DNA Binding
EC Number 3.2.1.17
Enzyme Function FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. {ECO:0000255|PROSITE-ProRule:PRU00680, ECO:0000269|PubMed:22044478}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (2); Beta strand (8); Binding site (1); Chain (1); Disulfide bond (4); Domain (1); Helix (8); Natural variant (3); Sequence conflict (3); Signal peptide (1); Turn (5)
Keywords 3D-structure;Allergen;Antimicrobial;Bacteriolytic enzyme;Direct protein sequencing;Disulfide bond;Glycosidase;Hydrolase;Reference proteome;Secreted;Signal
Interact With Itself; P0C0V0
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..18; /evidence=ECO:0000269|PubMed:14063294
Structure 3D X-ray crystallography (949); NMR spectroscopy (3); Neutron diffraction (2); Electron microscopy (13)
Cross Reference PDB 132L; 193L; 194L; 1A2Y; 1AKI; 1AT5; 1AT6; 1AZF; 1B0D; 1B2K; 1BGI; 1BHZ; 1BVK; 1BVX; 1BWH; 1BWI; 1BWJ; 1C08; 1C10; 1DPW; 1DPX; 1DQJ; 1E8L; 1F0W; 1F10; 1F3J; 1FDL; 1FLQ; 1FLU; 1FLW; 1FLY; 1FN5; 1G7H; 1G7I; 1G7J; 1G7L; 1G7M; 1GPQ; 1GWD; 1GXV; 1GXX; 1H6M; 1H87; 1HC0; 1HEL; 1HEM; 1HEN; 1HEO; 1HEP; 1HEQ; 1HER; 1HEW; 1HF4; 1HSW; 1HSX; 1IC4; 1IC5; 1IC7; 1IEE; 1IO5; 1IOQ; 1IOR; 1IOS; 1IOT; 1IR7; 1IR8; 1IR9; 1J1O; 1J1P; 1J1X; 1JA2; 1JA4; 1JA6; 1JA7; 1JIS; 1JIT; 1JIY; 1JJ0; 1JJ1; 1JJ3; 1JPO; 1JTO; 1JTT; 1KIP; 1KIQ; 1KIR; 1KXW; 1KXX; 1KXY; 1LCN; 1LJ3; 1LJ4; 1LJE; 1LJF; 1LJG; 1LJH; 1LJI; 1LJJ; 1LJK; 1LKR; 1LKS; 1LMA; 1LPI; 1LSA; 1LSB; 1LSC; 1LSD; 1LSE; 1LSF; 1LSG; 1LSM; 1LSN; 1LSY; 1LSZ; 1LYO; 1LYS; 1LYZ; 1LZ8; 1LZ9; 1LZA; 1LZB; 1LZC; 1LZD; 1LZE; 1LZG; 1LZH; 1LZN; 1LZT; 1MEL; 1MLC; 1N4F; 1NBY; 1NBZ; 1NDG; 1NDM; 1P2C; 1PS5; 1QIO; 1QTK; 1RCM; 1RFP; 1RI8; 1RJC; 1SF4; 1SF6; 1SF7; 1SFB; 1SFG; 1SQ2; 1T3P; 1T6V; 1UA6; 1UC0; 1UCO; 1UIA; 1UIB; 1UIC; 1UID; 1UIE; 1UIF; 1UIG; 1UIH; 1UUZ; 1V7S; 1V7T; 1VAT; 1VAU; 1VDP; 1VDQ; 1VDS; 1VDT; 1VED; 1VFB; 1W6Z; 1WTM; 1WTN; 1XEI; 1XEJ; 1XEK; 1XFP; 1XGP; 1XGQ; 1XGR; 1XGT; 1XGU; 1YIK; 1YIL; 1YKX; 1YKY; 1YKZ; 1YL0; 1YL1; 1YQV; 1Z55; 1ZMY; 1ZV5; 1ZVH; 1ZVY; 2A6U; 2A7D; 2A7F; 2AUB; 2B5Z; 2BLX; 2BLY; 2BPU; 2C8O; 2C8P; 2CDS; 2CGI; 2D4I; 2D4J; 2D4K; 2D6B; 2D91; 2DQC; 2DQD; 2DQE; 2DQF; 2DQG; 2DQH; 2DQI; 2DQJ; 2EIZ; 2EKS; 2EPE; 2F2N; 2F30; 2F4A; 2F4G; 2FBB; 2G4P; 2G4Q; 2H9J; 2H9K; 2HS7; 2HS9; 2HSO; 2HTX; 2HU1; 2HU3; 2HUB; 2I25; 2I26; 2I6Z; 2IFF; 2LYM; 2LYO; 2LYZ; 2LZH; 2LZT; 2PC2; 2Q0M; 2VB1; 2W1L; 2W1M; 2W1X; 2W1Y; 2WAR; 2X0A; 2XBR; 2XBS; 2XJW; 2XTH; 2YBH; 2YBI; 2YBJ; 2YBL; 2YBM; 2YBN; 2YDG; 2YSS; 2YVB; 2Z12; 2Z18; 2Z19; 2ZNW; 2ZNX; 2ZQ3; 2ZQ4; 2ZYP; 3A34; 3A3Q; 3A3R; 3A67; 3A6B; 3A6C; 3A8Z; 3A90; 3A91; 3A92; 3A93; 3A94; 3A95; 3A96; 3AGG; 3AGH; 3AGI; 3AJN; 3ATN; 3ATO; 3AW6; 3AW7; 3AZ4; 3AZ5; 3AZ6; 3AZ7; 3B6L; 3B72; 3D9A; 3E3D; 3EMS; 3EXD; 3F6Z; 3G3A; 3G3B; 3HFM; 3IJU; 3IJV; 3J4G; 3J6K; 3KAM; 3LYM; 3LYO; 3LYT; 3LYZ; 3LZT; 3M18; 3M3U; 3MBE; 3N9A; 3N9C; 3N9E; 3OJP; 3OK0; 3OTP; 3P4Z; 3P64; 3P65; 3P66; 3P68; 3QE8; 3QNG; 3QY4; 3RNX; 3RT5; 3RU5; 3RW8; 3RZ4; 3SP3; 3T6U; 3TMU; 3TMV; 3TMW; 3TMX; 3TXB; 3TXD; 3TXE; 3TXF; 3TXG; 3TXH; 3TXI; 3TXJ; 3TXK; 3ULR; 3W6A; 3WL2; 3WMK; 3WPJ; 3WPK; 3WPL; 3WU7; 3WU8; 3WU9; 3WUA; 3WUL; 3WUM; 3WUN; 3WVX; 3WVY; 3WW5; 3WW6; 3WXT; 3WXU; 3ZEK; 3ZVQ; 4A7D; 4A8A; 4A8B; 4AGA; 4AXT; 4B0D; 4B1A; 4B49; 4B4E; 4B4I; 4B4J; 4BAD; 4BAF; 4BAP; 4BS7; 4C3W; 4CJ2; 4D9Z; 4DC4; 4DD0; 4DD1; 4DD2; 4DD3; 4DD7; 4DD9; 4DDA; 4DDB; 4DDC; 4DT3; 4E3U; 4EOF; 4ET8; 4ET9; 4ETA; 4ETB; 4ETC; 4ETD; 4ETE; 4FJR; 4G49; 4G4B; 4G4C; 4G4H; 4GCB; 4GCC; 4GCD; 4GCE; 4GCF; 4GLA; 4GLV; 4GN3; 4GN4; 4GN5; 4H1P; 4H8X; 4H8Y; 4H8Z; 4H90; 4H91; 4H92; 4H93; 4H94; 4H9A; 4H9B; 4H9C; 4H9E; 4H9F; 4H9H; 4H9I; 4HP0; 4HPI; 4HSF; 4HTK; 4HTN; 4HTQ; 4HV1; 4HV2; 4I8S; 4IAS; 4IAT; 4II8; 4J1A; 4J1B; 4J7V; 4KXI; 4LFP; 4LFX; 4LGK; 4LT0; 4LT1; 4LT2; 4LT3; 4LYB; 4LYC; 4LYM; 4LYO; 4LYT; 4LYZ; 4LZT; 4M4O; 4M6D; 4MR1; 4N0J; 4N1C; 4N1E; 4N5R; 4N8Z; 4N9R; 4NEB; 4NFV; 4NG1; 4NG8; 4NGI; 4NGJ; 4NGK; 4NGL; 4NGO; 4NGV; 4NGW; 4NGY; 4NGZ; 4NHI; 4NHP; 4NHQ; 4NHS; 4NHT; 4NIJ; 4NSG; 4NSH; 4NSI; 4NSJ; 4NWE; 4NWH; 4NY5; 4O34; 4OOO; 4OOT; 4OWA; 4OWB; 4OWC; 4OWE; 4OWH; 4P2E; 4PGJ; 4PHI; 4PPO; 4PRQ; 4PRU; 4QEQ; 4QGZ; 4QY9; 4R0F; 4R6C; 4RDS; 4RLM; 4RLN; 4RW1; 4RW2; 4TSA; 4TSB; 4TSC; 4TTD; 4TUN; 4TWS; 4U3X; 4UWN; 4UWU; 4UWV; 4W94; 4W96; 4WG1; 4WG7; 4WL6; 4WL7; 4WLD; 4WLT; 4WLX; 4WLY; 4WM1; 4WM2; 4WM3; 4WM4; 4WM5; 4WM6; 4WMG; 4WO6; 4WO9; 4WOA; 4X3B; 4XAD; 4XEN; 4XJB; 4XJD; 4XJF; 4XJG; 4XJH; 4XJI; 4XN6; 4XYY; 4YEM; 4YEN; 4YEO; 4YM8; 4YOP; 4Z3M; 4Z41; 4Z46; 4Z98; 4ZEE; 4ZFP; 4ZIX; 5A3E; 5A3Z; 5AMY; 5APC; 5APD; 5APE; 5APF; 5B05; 5B06; 5B07; 5B1F; 5B1G; 5B59; 5B5J; 5C6I; 5C6J; 5C6L; 5D5C; 5D5F; 5DL9; 5DLA; 5DM9; 5E4P; 5E9R; 5EBH; 5F14; 5F16; 5F81; 5F9U; 5F9X; 5FCP; 5FDJ; 5FEK; 5FEL; 5FHW; 5FST; 5GWB; 5HLL; 5HMJ; 5HMV; 5HNC; 5HNL; 5HQ1; 5I4W; 5I4X; 5I4Y; 5I53; 5I54; 5I5Q; 5IDD; 5IEL; 5IHG; 5II3; 5ILC; 5ILF; 5J7C; 5JEN; 5K2K; 5K2N; 5K2P; 5K2Q; 5K2R; 5K2S; 5K7O; 5KJ9; 5KKI; 5KKJ; 5KXK; 5KXL; 5KXM; 5KXN; 5KXO; 5KXP; 5KXR; 5KXS; 5KXT; 5KXW; 5KXX; 5KXY; 5KXZ; 5KY1; 5L3H; 5L3I; 5L9J; 5LA5; 5LA8; 5LAF; 5LAG; 5LAN; 5LIN; 5LIO; 5LVG; 5LVH; 5LVI; 5LVJ; 5LXW; 5LYM; 5LYT; 5LYZ; 5M1Y; 5MJJ; 5MYY; 5NBJ; 5NE0; 5NJ1; 5NJM; 5NJP; 5NJQ; 5NJR; 5NJS; 5O4W; 5O4X; 5O6Q; 5OB6; 5OB7; 5OB8; 5OB9; 5OCV; 5OER; 5OLE; 5OOV; 5OOY; 5OP1; 5T3F; 5TK0; 5UVJ; 5V4G; 5V4H; 5V4I; 5WR9; 5WRA; 5WRB; 5YIN; 5YKY; 6A10; 6A4N; 6A4O; 6A4P; 6A4Q; 6ABN; 6ABZ; 6AC2; 6AD5; 6ADF; 6AEA; 6AGN; 6AGR; 6AHH; 6AHL; 6APM; 6B7U; 6B7V; 6B7W; 6BO1; 6BO2; 6BRE; 6CIW; 6D6E; 6D6F; 6D6G; 6D6H; 6F1L; 6F1M; 6F1O; 6F1P; 6F1R; 6F2I; 6F2J; 6F2K; 6F9X; 6F9Y; 6F9Z; 6FA0; 6FRO; 6FRQ; 6FSJ; 6FTR; 6G5C; 6G5V; 6G5Y; 6G8A; 6GF0; 6GNL; 6GOB; 6GOH; 6GOI; 6GOJ; 6H0K; 6H0L; 6H3B; 6H79; 6HT2; 6HU5; 6HY4; 6HY6; 6HY8; 6HYB; 6IG6; 6IRJ; 6JB2; 6JB5; 6JB8; 6JXP; 6JXQ; 6JZI; 6K5Q; 6K8G; 6KCB; 6KCD; 6KD1; 6LAV; 6LL3; 6LT5; 6LYT; 6LYZ; 6MQV; 6MUZ; 6MX9; 6O2H; 6P4A; 6P4B; 6P4D; 6PBB; 6PL9; 6PLA; 6PLB; 6Q88; 6Q8R; 6Q8T; 6QEA; 6QNB; 6QQ3; 6QQC; 6QQD; 6QQE; 6QQF; 6QWW; 6QWX; 6QWY; 6QWZ; 6QX0; 6QXW; 6QXX; 6QXY; 6QY0; 6QY1; 6QY2; 6QY4; 6QY5; 6RNB; 6RNC; 6RO3; 6RO5; 6RT1; 6RT3; 6RT9; 6RTA; 6RXI; 6S2N; 6S7N; 6SET; 6SEU; 6SEW; 6SEX; 6SEZ; 6SIJ; 6SIK; 6SIL; 6SIM; 6SR0; 6SR1; 6SR2; 6SR3; 6SR4; 6SR5; 6SYC; 6SYD; 6SYE; 6TVL; 6TVY; 6W7P; 6W8E; 6WEB; 6WEC; 6WGO; 6WRL; 6WRM; 6WX5; 6YBF; 6YBI; 6YJX; 6YOB; 6YOC; 6YOD; 6YOE; 6ZS8; 7A70; 7AC2; 7AVE; 7AVF; 7AVG; 7B9J; 7BAZ; 7BB1; 7BCU; 7BCX; 7BD0; 7BDM; 7BDZ; 7BE0; 7BE1; 7BE2; 7BEB; 7BEC; 7BHK; 7BHL; 7BHM; 7BHN; 7BMO; 7BMP; 7BMQ; 7BMR; 7BMS; 7BMT; 7BR5; 7BVM; 7BVO; 7BYO; 7BYP; 7C09; 7CDK; 7CDM; 7CDN; 7CDO; 7CDP; 7CDQ; 7CDR; 7CDS; 7CDT; 7CDU; 7CJZ; 7CQO; 7CVJ; 7CVL; 7D01; 7D02; 7D04; 7D05; 7D0W; 7DEQ; 7DER; 7DLN; 7DTB; 7DTF; 7E02; 7F26; 7JMU; 7KH5; 7KNK; 7L84; 7LYZ; 7NJF; 7NKF; 7P6M; 7PNH; 7S4W; 7WBD; 7WBE; 7WBF; 8LYZ; 9LYZ;
Mapped Pubmed ID 10089304; 10089340; 10089401; 10089406; 10216294; 10339407; 10339408; 10488102; 10639129; 10666615; 10828942; 10894169; 10944331; 10957630; 11092949; 11112507; 11112523; 11266617; 11274458; 11278658; 11297547; 11418760; 11468395; 11477222; 11518970; 11524565; 11676532; 11679726; 11717496; 11752774; 1185784; 11983077; 12037300; 12077436; 12351866; 12444085; 12515535; 12654268; 12709438; 12720276; 12740607; 12777806; 12962625; 14988501; 15039550; 15299341; 15299435; 15299529; 15299565; 15299672; 15299739; 15306883; 15319492; 15383540; 15608372; 15659390; 1569548; 15698573; 15701702; 15735330; 15858274; 1587860; 15930644; 15983424; 16095608; 16131750; 16131756; 16131760; 16301795; 16510972; 16510975; 16537393; 16552135; 16552138; 16600702; 16929100; 17120266; 17166830; 17180231; 17258766; 17327674; 17405861; 17461426; 17609782; 17704571; 18084073; 18227432; 18350532; 18522744; 1856865; 19018096; 19020357; 19028453; 19096177; 19417908; 19508200; 19543291; 19605465; 19781789; 20038580; 20124702; 20146274; 20407212; 20449250; 20606256; 20616002; 21070940; 21084280; 21204537; 21237160; 21278750; 21418524; 21458668; 21525642; 21802827; 21931220; 22042312; 22229733; 22245966; 22297987; 22383363; 22505256; 22505429; 22525758; 22653729; 22769726; 22868767; 22948927; 22993093; 2302326; 2302327; 23058288; 23123834; 23143236; 23223860; 23275170; 23295480; 23303182; 23396873; 23416304; 23517183; 23897469; 2398048; 24045294; 24252878; 24256441; 24270807; 24311579; 24465865; 24553967; 24796316; 24816088; 24823716; 24943911; 24969463; 25025479; 25040949; 25043871; 25068633; 25075341; 25084340; 25086503; 25195879; 25195880; 25195881; 25211169; 25215611; 25313321; 25340580; 25384243; 25427784; 25494847; 25521080; 25530835; 25605312; 25615864; 2563161; 25641793; 25664750; 25737448; 25760593; 25849385; 25849403; 25931079; 25945583; 25974859; 26022615; 26054833; 26057665; 26179600; 26249358; 26280387; 26327386; 26457423; 26527148; 26594370; 26627659; 26718545; 26798779; 26798828; 26866284; 26894538; 26919531; 26926993; 26948967; 26996959; 27040953; 27050125; 27050131; 27150272; 27226979; 27291073; 27377379; 27422088; 27470012; 27534812; 27573790; 27578887; 27599736; 2762305; 27841370; 27897281; 28009546; 28009548; 28192420; 28261000; 28319372; 28356519; 28361137; 28386083; 28512575; 28695858; 28702564; 28832129; 28875031; 28876237; 28912485; 29079797; 29123679; 29199979; 29353085; 29551291; 29713703; 29717719; 29717999; 29806881; 29904761; 30004541; 30154468; 30171169; 30198901; 30275593; 30279492; 30289410; 30398187; 30412756; 30691130; 30792457; 30794865; 30855249; 30867915; 30867928; 30943017; 31061502; 31282476; 31316810; 31316813; 31455801; 31472610; 31490174; 31490509; 31527838; 31576225; 31664051; 31692460; 31702582; 31798359; 31819148; 31832488; 31887389; 31919476; 32047034; 32081905; 32148849; 32152274; 32266561; 32286284; 32352028; 32397185; 32428017; 32627748; 32638771; 32684898; 32744257; 32825186; 32855302; 32876060; 32966481; 33109332; 33180473; 33209324; 33320144; 33396930; 33497565; 33540880; 33645532; 33949976; 33953924; 34076595; 34196088; 34197115; 34294694; 34426585; 34473086; 34473109; 34528438; 34638887; 34866613; 3586017; 4856347; 514367; 7527555; 7531245; 7707375; 7966295; 7966306; 8289250; 8302837; 8373783; 8387211; 8535241; 8784355; 8952503; 9348077; 9354379; 9360606; 9443341; 9463398; 9571046; 9609690; 9659395; 9714162; 9757091; 9757106; 9761848; 9828016;
Motif
Gene Encoded By
Mass 16,239
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda 3.2.1.17;