IED ID |
IndEnz0010000581 |
Enzyme Type ID |
esterase000581 |
Protein Name |
Lysozyme C
EC 3.2.1.17
1,4-beta-N-acetylmuramidase C
Allergen Gal d IV
allergen Gal d 4
|
Gene Name |
LYZ |
Organism |
Gallus gallus (Chicken) |
Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Sarcopterygii
Dipnotetrapodomorpha
Tetrapoda
Amniota
Sauropsida
Sauria (diapsids)
Archelosauria
Archosauria
Dinosauria
Saurischia
Theropoda
Coelurosauria
Aves
Neognathae
Galloanserae
Galliformes
Phasianidae (turkeys)
Phasianinae
Gallus
Gallus gallus (Chicken)
|
Enzyme Sequence |
MRSLLILVLCFLPLAALGKVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGSTDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVSDGNGMNAWVAWRNRCKGTDVQAWIRGCRL |
Enzyme Length |
147 |
Uniprot Accession Number |
P00698 |
Absorption |
|
Active Site |
ACT_SITE 53; ACT_SITE 70 |
Activity Regulation |
|
Binding Site |
BINDING 119; /note=Substrate |
Calcium Binding |
|
catalytic Activity |
CATALYTIC ACTIVITY: Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.; EC=3.2.1.17; |
DNA Binding |
|
EC Number |
3.2.1.17 |
Enzyme Function |
FUNCTION: Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus. {ECO:0000255|PROSITE-ProRule:PRU00680, ECO:0000269|PubMed:22044478}. |
Temperature Dependency |
|
PH Dependency |
|
Pathway |
|
nucleotide Binding |
|
Features |
Active site (2); Beta strand (8); Binding site (1); Chain (1); Disulfide bond (4); Domain (1); Helix (8); Natural variant (3); Sequence conflict (3); Signal peptide (1); Turn (5) |
Keywords |
3D-structure;Allergen;Antimicrobial;Bacteriolytic enzyme;Direct protein sequencing;Disulfide bond;Glycosidase;Hydrolase;Reference proteome;Secreted;Signal |
Interact With |
Itself; P0C0V0 |
Induction |
|
Subcellular Location |
SUBCELLULAR LOCATION: Secreted. |
Modified Residue |
|
Post Translational Modification |
|
Signal Peptide |
SIGNAL 1..18; /evidence=ECO:0000269|PubMed:14063294 |
Structure 3D |
X-ray crystallography (949); NMR spectroscopy (3); Neutron diffraction (2); Electron microscopy (13) |
Cross Reference PDB |
132L;
193L;
194L;
1A2Y;
1AKI;
1AT5;
1AT6;
1AZF;
1B0D;
1B2K;
1BGI;
1BHZ;
1BVK;
1BVX;
1BWH;
1BWI;
1BWJ;
1C08;
1C10;
1DPW;
1DPX;
1DQJ;
1E8L;
1F0W;
1F10;
1F3J;
1FDL;
1FLQ;
1FLU;
1FLW;
1FLY;
1FN5;
1G7H;
1G7I;
1G7J;
1G7L;
1G7M;
1GPQ;
1GWD;
1GXV;
1GXX;
1H6M;
1H87;
1HC0;
1HEL;
1HEM;
1HEN;
1HEO;
1HEP;
1HEQ;
1HER;
1HEW;
1HF4;
1HSW;
1HSX;
1IC4;
1IC5;
1IC7;
1IEE;
1IO5;
1IOQ;
1IOR;
1IOS;
1IOT;
1IR7;
1IR8;
1IR9;
1J1O;
1J1P;
1J1X;
1JA2;
1JA4;
1JA6;
1JA7;
1JIS;
1JIT;
1JIY;
1JJ0;
1JJ1;
1JJ3;
1JPO;
1JTO;
1JTT;
1KIP;
1KIQ;
1KIR;
1KXW;
1KXX;
1KXY;
1LCN;
1LJ3;
1LJ4;
1LJE;
1LJF;
1LJG;
1LJH;
1LJI;
1LJJ;
1LJK;
1LKR;
1LKS;
1LMA;
1LPI;
1LSA;
1LSB;
1LSC;
1LSD;
1LSE;
1LSF;
1LSG;
1LSM;
1LSN;
1LSY;
1LSZ;
1LYO;
1LYS;
1LYZ;
1LZ8;
1LZ9;
1LZA;
1LZB;
1LZC;
1LZD;
1LZE;
1LZG;
1LZH;
1LZN;
1LZT;
1MEL;
1MLC;
1N4F;
1NBY;
1NBZ;
1NDG;
1NDM;
1P2C;
1PS5;
1QIO;
1QTK;
1RCM;
1RFP;
1RI8;
1RJC;
1SF4;
1SF6;
1SF7;
1SFB;
1SFG;
1SQ2;
1T3P;
1T6V;
1UA6;
1UC0;
1UCO;
1UIA;
1UIB;
1UIC;
1UID;
1UIE;
1UIF;
1UIG;
1UIH;
1UUZ;
1V7S;
1V7T;
1VAT;
1VAU;
1VDP;
1VDQ;
1VDS;
1VDT;
1VED;
1VFB;
1W6Z;
1WTM;
1WTN;
1XEI;
1XEJ;
1XEK;
1XFP;
1XGP;
1XGQ;
1XGR;
1XGT;
1XGU;
1YIK;
1YIL;
1YKX;
1YKY;
1YKZ;
1YL0;
1YL1;
1YQV;
1Z55;
1ZMY;
1ZV5;
1ZVH;
1ZVY;
2A6U;
2A7D;
2A7F;
2AUB;
2B5Z;
2BLX;
2BLY;
2BPU;
2C8O;
2C8P;
2CDS;
2CGI;
2D4I;
2D4J;
2D4K;
2D6B;
2D91;
2DQC;
2DQD;
2DQE;
2DQF;
2DQG;
2DQH;
2DQI;
2DQJ;
2EIZ;
2EKS;
2EPE;
2F2N;
2F30;
2F4A;
2F4G;
2FBB;
2G4P;
2G4Q;
2H9J;
2H9K;
2HS7;
2HS9;
2HSO;
2HTX;
2HU1;
2HU3;
2HUB;
2I25;
2I26;
2I6Z;
2IFF;
2LYM;
2LYO;
2LYZ;
2LZH;
2LZT;
2PC2;
2Q0M;
2VB1;
2W1L;
2W1M;
2W1X;
2W1Y;
2WAR;
2X0A;
2XBR;
2XBS;
2XJW;
2XTH;
2YBH;
2YBI;
2YBJ;
2YBL;
2YBM;
2YBN;
2YDG;
2YSS;
2YVB;
2Z12;
2Z18;
2Z19;
2ZNW;
2ZNX;
2ZQ3;
2ZQ4;
2ZYP;
3A34;
3A3Q;
3A3R;
3A67;
3A6B;
3A6C;
3A8Z;
3A90;
3A91;
3A92;
3A93;
3A94;
3A95;
3A96;
3AGG;
3AGH;
3AGI;
3AJN;
3ATN;
3ATO;
3AW6;
3AW7;
3AZ4;
3AZ5;
3AZ6;
3AZ7;
3B6L;
3B72;
3D9A;
3E3D;
3EMS;
3EXD;
3F6Z;
3G3A;
3G3B;
3HFM;
3IJU;
3IJV;
3J4G;
3J6K;
3KAM;
3LYM;
3LYO;
3LYT;
3LYZ;
3LZT;
3M18;
3M3U;
3MBE;
3N9A;
3N9C;
3N9E;
3OJP;
3OK0;
3OTP;
3P4Z;
3P64;
3P65;
3P66;
3P68;
3QE8;
3QNG;
3QY4;
3RNX;
3RT5;
3RU5;
3RW8;
3RZ4;
3SP3;
3T6U;
3TMU;
3TMV;
3TMW;
3TMX;
3TXB;
3TXD;
3TXE;
3TXF;
3TXG;
3TXH;
3TXI;
3TXJ;
3TXK;
3ULR;
3W6A;
3WL2;
3WMK;
3WPJ;
3WPK;
3WPL;
3WU7;
3WU8;
3WU9;
3WUA;
3WUL;
3WUM;
3WUN;
3WVX;
3WVY;
3WW5;
3WW6;
3WXT;
3WXU;
3ZEK;
3ZVQ;
4A7D;
4A8A;
4A8B;
4AGA;
4AXT;
4B0D;
4B1A;
4B49;
4B4E;
4B4I;
4B4J;
4BAD;
4BAF;
4BAP;
4BS7;
4C3W;
4CJ2;
4D9Z;
4DC4;
4DD0;
4DD1;
4DD2;
4DD3;
4DD7;
4DD9;
4DDA;
4DDB;
4DDC;
4DT3;
4E3U;
4EOF;
4ET8;
4ET9;
4ETA;
4ETB;
4ETC;
4ETD;
4ETE;
4FJR;
4G49;
4G4B;
4G4C;
4G4H;
4GCB;
4GCC;
4GCD;
4GCE;
4GCF;
4GLA;
4GLV;
4GN3;
4GN4;
4GN5;
4H1P;
4H8X;
4H8Y;
4H8Z;
4H90;
4H91;
4H92;
4H93;
4H94;
4H9A;
4H9B;
4H9C;
4H9E;
4H9F;
4H9H;
4H9I;
4HP0;
4HPI;
4HSF;
4HTK;
4HTN;
4HTQ;
4HV1;
4HV2;
4I8S;
4IAS;
4IAT;
4II8;
4J1A;
4J1B;
4J7V;
4KXI;
4LFP;
4LFX;
4LGK;
4LT0;
4LT1;
4LT2;
4LT3;
4LYB;
4LYC;
4LYM;
4LYO;
4LYT;
4LYZ;
4LZT;
4M4O;
4M6D;
4MR1;
4N0J;
4N1C;
4N1E;
4N5R;
4N8Z;
4N9R;
4NEB;
4NFV;
4NG1;
4NG8;
4NGI;
4NGJ;
4NGK;
4NGL;
4NGO;
4NGV;
4NGW;
4NGY;
4NGZ;
4NHI;
4NHP;
4NHQ;
4NHS;
4NHT;
4NIJ;
4NSG;
4NSH;
4NSI;
4NSJ;
4NWE;
4NWH;
4NY5;
4O34;
4OOO;
4OOT;
4OWA;
4OWB;
4OWC;
4OWE;
4OWH;
4P2E;
4PGJ;
4PHI;
4PPO;
4PRQ;
4PRU;
4QEQ;
4QGZ;
4QY9;
4R0F;
4R6C;
4RDS;
4RLM;
4RLN;
4RW1;
4RW2;
4TSA;
4TSB;
4TSC;
4TTD;
4TUN;
4TWS;
4U3X;
4UWN;
4UWU;
4UWV;
4W94;
4W96;
4WG1;
4WG7;
4WL6;
4WL7;
4WLD;
4WLT;
4WLX;
4WLY;
4WM1;
4WM2;
4WM3;
4WM4;
4WM5;
4WM6;
4WMG;
4WO6;
4WO9;
4WOA;
4X3B;
4XAD;
4XEN;
4XJB;
4XJD;
4XJF;
4XJG;
4XJH;
4XJI;
4XN6;
4XYY;
4YEM;
4YEN;
4YEO;
4YM8;
4YOP;
4Z3M;
4Z41;
4Z46;
4Z98;
4ZEE;
4ZFP;
4ZIX;
5A3E;
5A3Z;
5AMY;
5APC;
5APD;
5APE;
5APF;
5B05;
5B06;
5B07;
5B1F;
5B1G;
5B59;
5B5J;
5C6I;
5C6J;
5C6L;
5D5C;
5D5F;
5DL9;
5DLA;
5DM9;
5E4P;
5E9R;
5EBH;
5F14;
5F16;
5F81;
5F9U;
5F9X;
5FCP;
5FDJ;
5FEK;
5FEL;
5FHW;
5FST;
5GWB;
5HLL;
5HMJ;
5HMV;
5HNC;
5HNL;
5HQ1;
5I4W;
5I4X;
5I4Y;
5I53;
5I54;
5I5Q;
5IDD;
5IEL;
5IHG;
5II3;
5ILC;
5ILF;
5J7C;
5JEN;
5K2K;
5K2N;
5K2P;
5K2Q;
5K2R;
5K2S;
5K7O;
5KJ9;
5KKI;
5KKJ;
5KXK;
5KXL;
5KXM;
5KXN;
5KXO;
5KXP;
5KXR;
5KXS;
5KXT;
5KXW;
5KXX;
5KXY;
5KXZ;
5KY1;
5L3H;
5L3I;
5L9J;
5LA5;
5LA8;
5LAF;
5LAG;
5LAN;
5LIN;
5LIO;
5LVG;
5LVH;
5LVI;
5LVJ;
5LXW;
5LYM;
5LYT;
5LYZ;
5M1Y;
5MJJ;
5MYY;
5NBJ;
5NE0;
5NJ1;
5NJM;
5NJP;
5NJQ;
5NJR;
5NJS;
5O4W;
5O4X;
5O6Q;
5OB6;
5OB7;
5OB8;
5OB9;
5OCV;
5OER;
5OLE;
5OOV;
5OOY;
5OP1;
5T3F;
5TK0;
5UVJ;
5V4G;
5V4H;
5V4I;
5WR9;
5WRA;
5WRB;
5YIN;
5YKY;
6A10;
6A4N;
6A4O;
6A4P;
6A4Q;
6ABN;
6ABZ;
6AC2;
6AD5;
6ADF;
6AEA;
6AGN;
6AGR;
6AHH;
6AHL;
6APM;
6B7U;
6B7V;
6B7W;
6BO1;
6BO2;
6BRE;
6CIW;
6D6E;
6D6F;
6D6G;
6D6H;
6F1L;
6F1M;
6F1O;
6F1P;
6F1R;
6F2I;
6F2J;
6F2K;
6F9X;
6F9Y;
6F9Z;
6FA0;
6FRO;
6FRQ;
6FSJ;
6FTR;
6G5C;
6G5V;
6G5Y;
6G8A;
6GF0;
6GNL;
6GOB;
6GOH;
6GOI;
6GOJ;
6H0K;
6H0L;
6H3B;
6H79;
6HT2;
6HU5;
6HY4;
6HY6;
6HY8;
6HYB;
6IG6;
6IRJ;
6JB2;
6JB5;
6JB8;
6JXP;
6JXQ;
6JZI;
6K5Q;
6K8G;
6KCB;
6KCD;
6KD1;
6LAV;
6LL3;
6LT5;
6LYT;
6LYZ;
6MQV;
6MUZ;
6MX9;
6O2H;
6P4A;
6P4B;
6P4D;
6PBB;
6PL9;
6PLA;
6PLB;
6Q88;
6Q8R;
6Q8T;
6QEA;
6QNB;
6QQ3;
6QQC;
6QQD;
6QQE;
6QQF;
6QWW;
6QWX;
6QWY;
6QWZ;
6QX0;
6QXW;
6QXX;
6QXY;
6QY0;
6QY1;
6QY2;
6QY4;
6QY5;
6RNB;
6RNC;
6RO3;
6RO5;
6RT1;
6RT3;
6RT9;
6RTA;
6RXI;
6S2N;
6S7N;
6SET;
6SEU;
6SEW;
6SEX;
6SEZ;
6SIJ;
6SIK;
6SIL;
6SIM;
6SR0;
6SR1;
6SR2;
6SR3;
6SR4;
6SR5;
6SYC;
6SYD;
6SYE;
6TVL;
6TVY;
6W7P;
6W8E;
6WEB;
6WEC;
6WGO;
6WRL;
6WRM;
6WX5;
6YBF;
6YBI;
6YJX;
6YOB;
6YOC;
6YOD;
6YOE;
6ZS8;
7A70;
7AC2;
7AVE;
7AVF;
7AVG;
7B9J;
7BAZ;
7BB1;
7BCU;
7BCX;
7BD0;
7BDM;
7BDZ;
7BE0;
7BE1;
7BE2;
7BEB;
7BEC;
7BHK;
7BHL;
7BHM;
7BHN;
7BMO;
7BMP;
7BMQ;
7BMR;
7BMS;
7BMT;
7BR5;
7BVM;
7BVO;
7BYO;
7BYP;
7C09;
7CDK;
7CDM;
7CDN;
7CDO;
7CDP;
7CDQ;
7CDR;
7CDS;
7CDT;
7CDU;
7CJZ;
7CQO;
7CVJ;
7CVL;
7D01;
7D02;
7D04;
7D05;
7D0W;
7DEQ;
7DER;
7DLN;
7DTB;
7DTF;
7E02;
7F26;
7JMU;
7KH5;
7KNK;
7L84;
7LYZ;
7NJF;
7NKF;
7P6M;
7PNH;
7S4W;
7WBD;
7WBE;
7WBF;
8LYZ;
9LYZ;
|
Mapped Pubmed ID |
10089304;
10089340;
10089401;
10089406;
10216294;
10339407;
10339408;
10488102;
10639129;
10666615;
10828942;
10894169;
10944331;
10957630;
11092949;
11112507;
11112523;
11266617;
11274458;
11278658;
11297547;
11418760;
11468395;
11477222;
11518970;
11524565;
11676532;
11679726;
11717496;
11752774;
1185784;
11983077;
12037300;
12077436;
12351866;
12444085;
12515535;
12654268;
12709438;
12720276;
12740607;
12777806;
12962625;
14988501;
15039550;
15299341;
15299435;
15299529;
15299565;
15299672;
15299739;
15306883;
15319492;
15383540;
15608372;
15659390;
1569548;
15698573;
15701702;
15735330;
15858274;
1587860;
15930644;
15983424;
16095608;
16131750;
16131756;
16131760;
16301795;
16510972;
16510975;
16537393;
16552135;
16552138;
16600702;
16929100;
17120266;
17166830;
17180231;
17258766;
17327674;
17405861;
17461426;
17609782;
17704571;
18084073;
18227432;
18350532;
18522744;
1856865;
19018096;
19020357;
19028453;
19096177;
19417908;
19508200;
19543291;
19605465;
19781789;
20038580;
20124702;
20146274;
20407212;
20449250;
20606256;
20616002;
21070940;
21084280;
21204537;
21237160;
21278750;
21418524;
21458668;
21525642;
21802827;
21931220;
22042312;
22229733;
22245966;
22297987;
22383363;
22505256;
22505429;
22525758;
22653729;
22769726;
22868767;
22948927;
22993093;
2302326;
2302327;
23058288;
23123834;
23143236;
23223860;
23275170;
23295480;
23303182;
23396873;
23416304;
23517183;
23897469;
2398048;
24045294;
24252878;
24256441;
24270807;
24311579;
24465865;
24553967;
24796316;
24816088;
24823716;
24943911;
24969463;
25025479;
25040949;
25043871;
25068633;
25075341;
25084340;
25086503;
25195879;
25195880;
25195881;
25211169;
25215611;
25313321;
25340580;
25384243;
25427784;
25494847;
25521080;
25530835;
25605312;
25615864;
2563161;
25641793;
25664750;
25737448;
25760593;
25849385;
25849403;
25931079;
25945583;
25974859;
26022615;
26054833;
26057665;
26179600;
26249358;
26280387;
26327386;
26457423;
26527148;
26594370;
26627659;
26718545;
26798779;
26798828;
26866284;
26894538;
26919531;
26926993;
26948967;
26996959;
27040953;
27050125;
27050131;
27150272;
27226979;
27291073;
27377379;
27422088;
27470012;
27534812;
27573790;
27578887;
27599736;
2762305;
27841370;
27897281;
28009546;
28009548;
28192420;
28261000;
28319372;
28356519;
28361137;
28386083;
28512575;
28695858;
28702564;
28832129;
28875031;
28876237;
28912485;
29079797;
29123679;
29199979;
29353085;
29551291;
29713703;
29717719;
29717999;
29806881;
29904761;
30004541;
30154468;
30171169;
30198901;
30275593;
30279492;
30289410;
30398187;
30412756;
30691130;
30792457;
30794865;
30855249;
30867915;
30867928;
30943017;
31061502;
31282476;
31316810;
31316813;
31455801;
31472610;
31490174;
31490509;
31527838;
31576225;
31664051;
31692460;
31702582;
31798359;
31819148;
31832488;
31887389;
31919476;
32047034;
32081905;
32148849;
32152274;
32266561;
32286284;
32352028;
32397185;
32428017;
32627748;
32638771;
32684898;
32744257;
32825186;
32855302;
32876060;
32966481;
33109332;
33180473;
33209324;
33320144;
33396930;
33497565;
33540880;
33645532;
33949976;
33953924;
34076595;
34196088;
34197115;
34294694;
34426585;
34473086;
34473109;
34528438;
34638887;
34866613;
3586017;
4856347;
514367;
7527555;
7531245;
7707375;
7966295;
7966306;
8289250;
8302837;
8373783;
8387211;
8535241;
8784355;
8952503;
9348077;
9354379;
9360606;
9443341;
9463398;
9571046;
9609690;
9659395;
9714162;
9757091;
9757106;
9761848;
9828016;
|
Motif |
|
Gene Encoded By |
|
Mass |
16,239 |
Kinetics |
|
Metal Binding |
|
Rhea ID |
|
Cross Reference Brenda |
3.2.1.17; |