| IED ID | IndEnz0010000687 |
| Enzyme Type ID | esterase000687 |
| Protein Name |
Glutathione-dependent formaldehyde-activating enzyme EC 4.4.1.22 S- hydroxymethyl glutathione synthase |
| Gene Name | gfa |
| Organism | Paracoccus denitrificans |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Alphaproteobacteria Rhodobacterales Rhodobacteraceae Paracoccus Paracoccus denitrificans |
| Enzyme Sequence | MVDTSGVKIHPAVDNGIKPAQPGFAGGTLHCKCSTNPVRVAVRAQTAHNHVCGCTKCWKPEGAIFSQVAVVGRDALEVLEGAEKLEIVNAEAPIQRHRCRDCGVHMYGRIENRDHPFYGLDFVHTELSDEDGWSAPEFAAFVSSIIESGVDPSRMEAIRARLRELGLEPYDALSPPLMDAIATHIAKRSGALAA |
| Enzyme Length | 194 |
| Uniprot Accession Number | Q51669 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=S-(hydroxymethyl)glutathione = formaldehyde + glutathione; Xref=Rhea:RHEA:22488, ChEBI:CHEBI:16842, ChEBI:CHEBI:57925, ChEBI:CHEBI:58758; EC=4.4.1.22; |
| DNA Binding | |
| EC Number | 4.4.1.22 |
| Enzyme Function | FUNCTION: Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione. {ECO:0000269|PubMed:11741920}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | PATHWAY: One-carbon metabolism; formaldehyde degradation; formate from formaldehyde (glutathione route): step 1/3. |
| nucleotide Binding | |
| Features | Beta strand (14); Chain (1); Domain (1); Helix (8); Initiator methionine (1); Metal binding (7); Turn (2) |
| Keywords | 3D-structure;Direct protein sequencing;Lyase;Metal-binding;Zinc |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (2) |
| Cross Reference PDB | 1X6M; 1XA8; |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 20,967 |
| Kinetics | |
| Metal Binding | METAL 31; /note=Zinc 1; structural; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239; METAL 33; /note=Zinc 1; structural; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239; METAL 52; /note=Zinc 2; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239; METAL 54; /note=Zinc 2; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239; METAL 57; /note=Zinc 2; catalytic; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239; METAL 99; /note=Zinc 1; structural; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239; METAL 102; /note=Zinc 1; structural; /evidence=ECO:0000255|PROSITE-ProRule:PRU01239 |
| Rhea ID | RHEA:22488 |
| Cross Reference Brenda | 4.4.1.22; |