| IED ID | IndEnz0010000774 |
| Enzyme Type ID | esterase000774 |
| Protein Name |
Iron III enterobactin esterase EC 3.1.1.108 Enterochelin esterase Ferric enterobactin esterase |
| Gene Name | fes cbsH Dda3937_03040 |
| Organism | Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) |
| Taxonomic Lineage | cellular organisms Bacteria Proteobacteria Gammaproteobacteria Enterobacterales Pectobacteriaceae Dickeya Dickeya dadantii Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)) |
| Enzyme Sequence | MPAAQPSGFVATLLSSPQAGEEAWWQQVARLGTPLVEAQDSGRVRMTFLWRDPDGDERYSAIRRVYADINGVTDHHSTDPQSLERLPGTDVWHWSMAIEHDWRGSYSLIPIVAAQLPPVFSDDGQLRDEQQREWWCSLFPCAIADPLNRDQSWGEQLSAAHMPAAPSQQAWRAVDNGTALPPDAARLTVLDWKSEQLDNQRRIWLYTTGISDEPAQRPLCIVLDGQKWAEETPLFAALEAETAAGHLPPAVWLFIDAIDGETRCRELPCDAAFWLAVQDELLPQAARLAPFSDDPDRTVVSGQSYGGLAALYAGLHWPQRFGRVLTQSGSFWWPNLQFITDFDQRDTLEPGVLVTEVRQGGQTAWPLVIFQEAGRREADIAFVNQQMHEALVAAGHQVHQRVYAGGHDTLCWRGGLIDGFRWLLTGDDPQAASRD |
| Enzyme Length | 435 |
| Uniprot Accession Number | O51900 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Fe(III)-enterobactin + H(+) + 3 H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine; Xref=Rhea:RHEA:30111, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28199, ChEBI:CHEBI:58154, ChEBI:CHEBI:143010; EC=3.1.1.108; Evidence={ECO:0000250|UniProtKB:P13039};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:30112; Evidence={ECO:0000250|UniProtKB:P13039}; CATALYTIC ACTIVITY: Reaction=Fe(III)-enterobactin + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+); Xref=Rhea:RHEA:59256, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28199, ChEBI:CHEBI:143011; Evidence={ECO:0000250|UniProtKB:P13039};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59257; Evidence={ECO:0000250|UniProtKB:P13039}; CATALYTIC ACTIVITY: Reaction=Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]3 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + N-(2,3-dihydroxybenzoyl)-L-serine; Xref=Rhea:RHEA:59260, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58154, ChEBI:CHEBI:143011, ChEBI:CHEBI:143012; Evidence={ECO:0000250|UniProtKB:P13039};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59261; Evidence={ECO:0000250|UniProtKB:P13039}; CATALYTIC ACTIVITY: Reaction=Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine]2 + H(+) + H2O = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + N-(2,3-dihydroxybenzoyl)-L-serine; Xref=Rhea:RHEA:59264, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58154, ChEBI:CHEBI:143010, ChEBI:CHEBI:143012; Evidence={ECO:0000250|UniProtKB:P13039};PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59265; Evidence={ECO:0000250|UniProtKB:P13039}; |
| DNA Binding | |
| EC Number | 3.1.1.108 |
| Enzyme Function | FUNCTION: Catalyzes the hydrolysis of ferric enterobactin (Fe-Ent). Is responsible for the release of iron from ferric enterobactin. {ECO:0000250|UniProtKB:P13039}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Erroneous initiation (1); Sequence conflict (8) |
| Keywords | Cytoplasm;Hydrolase;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P13039}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 48,604 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:30111; RHEA:30112; RHEA:59256; RHEA:59257; RHEA:59260; RHEA:59261; RHEA:59264; RHEA:59265 |
| Cross Reference Brenda | 3.1.1.108; |