| IED ID | IndEnz0010000799 |
| Enzyme Type ID | esterase000799 |
| Protein Name |
Venom peptide 7.1 Venom peptide 7 Cleaved into: Venom peptide 7.2 |
| Gene Name | |
| Organism | Tityus serrulatus (Brazilian scorpion) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Chelicerata Arachnida Scorpiones Buthida Buthoidea Buthidae Tityus Tityus serrulatus (Brazilian scorpion) |
| Enzyme Sequence | RLRSKGKK |
| Enzyme Length | 8 |
| Uniprot Accession Number | P86828 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: [Venom peptide 7.1]: Has a weak inhibitory effect on voltage-gated sodium channel Nav1.5/SCN5A. Inhibits acetylcholine esterase in vitro. Increases interleukin-6 secretion from macrophages in vitro. Has no antifungal, antiviral or cytotoxic activity. {ECO:0000269|PubMed:27221550}.; FUNCTION: [Venom peptide 7.2]: Strongly inhibits acetylcholine esterase in vitro. Increases Il-6 secretion from macrophages in vitro. Has no antifungal, antiviral or cytotoxic activity. {ECO:0000269|PubMed:27221550}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Peptide (2); Sequence uncertainty (2) |
| Keywords | Direct protein sequencing;Ion channel impairing toxin;Secreted;Toxin;Voltage-gated sodium channel impairing toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18718845, ECO:0000269|PubMed:27221550}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 972 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |