| IED ID |
IndEnz0010000800 |
| Enzyme Type ID |
esterase000800 |
| Protein Name |
Venom peptide 8
|
| Gene Name |
|
| Organism |
Tityus serrulatus (Brazilian scorpion) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Protostomia
Ecdysozoa
Panarthropoda
Arthropoda
Chelicerata
Arachnida
Scorpiones
Buthida
Buthoidea
Buthidae
Tityus
Tityus serrulatus (Brazilian scorpion)
|
| Enzyme Sequence |
KIWRS |
| Enzyme Length |
5 |
| Uniprot Accession Number |
C0HJT2 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Has a weak inhibitory effect on voltage-gated sodium channel Nav1.2/SCN2A. Weakly inhibits acetylcholine esterase in vitro. Increases interleukin-6 secretion from macrophages in vitro. Has no antifungal, antiviral or cytotoxic activity. {ECO:0000269|PubMed:27221550}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Peptide (1) |
| Keywords |
Direct protein sequencing;Ion channel impairing toxin;Secreted;Toxin;Voltage-gated sodium channel impairing toxin |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27221550}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
689 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|