| IED ID | IndEnz0010000824 |
| Enzyme Type ID | esterase000824 |
| Protein Name |
Carboxylesterase 4A EC 3.1.1.- |
| Gene Name | Ces4a Ces8 |
| Organism | Mus musculus (Mouse) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Glires (Rodents and rabbits) Rodentia Myomorpha (mice and others) Muroidea Muridae Murinae Mus Mus Mus musculus (Mouse) |
| Enzyme Sequence | MAEAGWNMKWILGLSLTLCLVVQTALGALHTKEPLLITKHGILQGKQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPSCLQESWGQILSMYLNTRKQYKWLHFSEDCLYLNVYAPVLAPGAPLLPVMVWFPGGAFLAGSASTYEGSELAARGKVVLVFLQYRLGILGFFSTGNSHARGNWGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLKAFITPDPLTSAKKIAHLAGCDHNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSHKDPKEIVWFLSPVVDGVVFPEDPVVLLTRGQVKPVPYLLGVNNAEFEWNLPFLMKIQLNQRMMNQTNINKILWSFNVLLNITKEQVPVVAREYLNDAISNHDWKMFRNRLIDLIGDATFVYATLQAARYHRDAGSPVYLYEFKHHASSGIIIKPYNGADHGDELSYLFGSPFSKGSSAGEEKEFSLQMMKYWANFAHTGNPNGEKLPYWPRFDKDEKYLQLDFDTRVGVKLKEKKMAFWSQLRQSQKP |
| Enzyme Length | 563 |
| Uniprot Accession Number | Q8R0W5 |
| Absorption | |
| Active Site | ACT_SITE 228; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 360; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 475; /note=Charge relay system; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.1.- |
| Enzyme Function | FUNCTION: Probable carboxylesterase. {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (2); Erroneous initiation (1); Glycosylation (3); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Reference proteome;Secreted;Serine esterase;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..27; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 20931200; 21677750; 24194600; 27626380; |
| Motif | |
| Gene Encoded By | |
| Mass | 62,883 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |