Detail Information for IndEnz0010000827
IED ID IndEnz0010000827
Enzyme Type ID esterase000827
Protein Name Esterase-5A
Est-5A
EC 3.1.1.1
Carboxylic-ester hydrolase 5A
Carboxylesterase-5A
Gene Name Est-5A Est5A
Organism Drosophila miranda (Fruit fly)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Panarthropoda Arthropoda Mandibulata Pancrustacea Hexapoda Insecta Dicondylia Pterygota (winged insects) Neoptera Endopterygota Diptera Brachycera Muscomorpha Eremoneura Cyclorrhapha Schizophora Acalyptratae Ephydroidea Drosophilidae (pomace flies) Drosophilinae Drosophilini Drosophila (fruit flies) Sophophora obscura group pseudoobscura subgroup Drosophila miranda (Fruit fly)
Enzyme Sequence MHLVRWLICLIQLWIQLGAAGSVTLLDPLLIEIPNGKLRGRDNGHYYSYEAIPYAEPPTGELRFEVPKPYKQQWTNTFDATQPPVLCMQWNQFINGTNKLLGVEDCLTVSVYRPKNSSRNNFPVVANLHGGAFMFGGPSQYGHENIMREGSVILVTIGYRLGPLGFVSTGDADLSGNFGLKDQRLALLWIKQNIASFGGEPENILVVGHSAGGASVHLQMLREDFSKVAKAAISFSGNALDPWVIQQGLRGRTFELGRIVGCGQASDSVTLKKCLKSKPASEIVSAVQSFLVFSYVPFTPFGPAIESPDAPEAFITQHPIDIIKSGKFAQVPWAVTYTTEDGGYNAALLLEKQASSGRELILDLNDRWFDWAPYLLFYRDSMTTIKDMDDYSRKLRQEYLGDRRFSVESYWDVQRMFTDLLFKNSVTVSVDLHRKYGKSPVYAFVYDNPAEVGVGQILSGRNDVYFGTVHGDDVFLIFNVSFVPANRRPDEQIISRNFIKMLEYFALSTNDTMAYGDCVFQNNVGSKHMQLLSITRDGCENKQLNCFIQRCLIFF
Enzyme Length 555
Uniprot Accession Number O16168
Absorption
Active Site ACT_SITE 210; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039};
DNA Binding
EC Number 3.1.1.1
Enzyme Function
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (1); Chain (1); Disulfide bond (3); Glycosylation (4); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Secreted;Serine esterase;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..19; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID 11164043; 12930746; 8587496; 874309; 8878680;
Motif
Gene Encoded By
Mass 62,282
Kinetics
Metal Binding
Rhea ID RHEA:21164
Cross Reference Brenda