| IED ID | IndEnz0010000906 |
| Enzyme Type ID | esterase000906 |
| Protein Name |
Lipase A EC 3.1.1.3 |
| Gene Name | ARB_00790 |
| Organism | Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Arthroderma benhamiae (Trichophyton mentagrophytes) Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes) |
| Enzyme Sequence | MMFLTQLVSALFLFFLGPISYGKPVETFVLPLAQDAPIPPSEDPFYQPPPGYEETEPGTVLRQRRPPFPISLFRSAPIDLAATYQVLYRSSDTFGQPTATVSTILIPHNANMSKVLSYQVVEDAAFINCAPSYALQLHSDPGGLFGTIIIQSELLLITAALENGWVVTIPDYEGPAAAFLAYWRAGYATLDGIRATLASSGFTGVDPDAAVGLWGTSGGSVASAFAADLHPKYAPELNIVGAALGGVVPSITTALHSLNKGFDAGIIVSGVIGLSKEYTYMQPILESYLVPHLRDKFMSAGKKCSGAVSLDFRMEDIFSYFKGGEESGLFADPRVKAILDHNAMPQGVPEIPILILKSVNDEISPISDTDALVEKYCSNGVTIDYKRDLLSVHTILAVTGAPEAVLWLRDRLDGITVEKGCKTSTIFMTLLQPGALEVMSKTIIDNLLNLLGKPVGPRLRTEIVHVPPL |
| Enzyme Length | 469 |
| Uniprot Accession Number | D4AX63 |
| Absorption | |
| Active Site | ACT_SITE 217; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:W3VKA4; ACT_SITE 361; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:W3VKA4; ACT_SITE 393; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:W3VKA4 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000250|UniProtKB:W3VKA4}; |
| DNA Binding | |
| EC Number | 3.1.1.3 |
| Enzyme Function | FUNCTION: Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8). {ECO:0000250|UniProtKB:W3VKA4}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Disulfide bond (2); Glycosylation (1); Region (1); Signal peptide (1) |
| Keywords | Disulfide bond;Glycoprotein;Hydrolase;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:W3VKA4}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..22; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 50,460 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:12044 |
| Cross Reference Brenda |