Detail Information for IndEnz0010000906
IED ID IndEnz0010000906
Enzyme Type ID esterase000906
Protein Name Lipase A
EC 3.1.1.3
Gene Name ARB_00790
Organism Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Onygenales Arthrodermataceae (dermatophytes) Trichophyton Arthroderma benhamiae (Trichophyton mentagrophytes) Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton mentagrophytes)
Enzyme Sequence MMFLTQLVSALFLFFLGPISYGKPVETFVLPLAQDAPIPPSEDPFYQPPPGYEETEPGTVLRQRRPPFPISLFRSAPIDLAATYQVLYRSSDTFGQPTATVSTILIPHNANMSKVLSYQVVEDAAFINCAPSYALQLHSDPGGLFGTIIIQSELLLITAALENGWVVTIPDYEGPAAAFLAYWRAGYATLDGIRATLASSGFTGVDPDAAVGLWGTSGGSVASAFAADLHPKYAPELNIVGAALGGVVPSITTALHSLNKGFDAGIIVSGVIGLSKEYTYMQPILESYLVPHLRDKFMSAGKKCSGAVSLDFRMEDIFSYFKGGEESGLFADPRVKAILDHNAMPQGVPEIPILILKSVNDEISPISDTDALVEKYCSNGVTIDYKRDLLSVHTILAVTGAPEAVLWLRDRLDGITVEKGCKTSTIFMTLLQPGALEVMSKTIIDNLLNLLGKPVGPRLRTEIVHVPPL
Enzyme Length 469
Uniprot Accession Number D4AX63
Absorption
Active Site ACT_SITE 217; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:W3VKA4; ACT_SITE 361; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:W3VKA4; ACT_SITE 393; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:W3VKA4
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+); Xref=Rhea:RHEA:12044, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17855, ChEBI:CHEBI:18035, ChEBI:CHEBI:28868; EC=3.1.1.3; Evidence={ECO:0000250|UniProtKB:W3VKA4};
DNA Binding
EC Number 3.1.1.3
Enzyme Function FUNCTION: Hydrolyzes triglycerides, with a preference for substrates with short-chain lengths (C4 to C8). {ECO:0000250|UniProtKB:W3VKA4}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (2); Glycosylation (1); Region (1); Signal peptide (1)
Keywords Disulfide bond;Glycoprotein;Hydrolase;Lipid degradation;Lipid metabolism;Reference proteome;Secreted;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:W3VKA4}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..22; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 50,460
Kinetics
Metal Binding
Rhea ID RHEA:12044
Cross Reference Brenda