| IED ID | IndEnz0010000917 |
| Enzyme Type ID | esterase000917 |
| Protein Name |
F-box/WD repeat-containing protein mec-15 Mechanosensory abnormality protein 15 |
| Gene Name | mec-15 T01E8.4 |
| Organism | Caenorhabditis elegans |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Protostomia Ecdysozoa Nematoda (roundworms) Chromadorea Rhabditida Rhabditina Rhabditomorpha Rhabditoidea Rhabditidae Peloderinae Caenorhabditis Caenorhabditis elegans |
| Enzyme Sequence | MTNAQPTELISLPSELLCHLFTYLPQRQLITEIPLVCRRFNTILNDDKFWSRRIRTEQKVRLPDCELKHPEYEPKKSFYAMHRQRDRWRAWETQTVITAPGHSATVDSVMLFENNNKQFCLSGSRDRTIRLWSIENARNGEDTEQNPWTVAKDDTAHSGWIWNMAQESTSTNFYTTSWDSTVKSWHITDNGALQNLNSVNVGSAAQCISCSGNENEVVCTTFAKRVAVIDSRTFQVVADHKLHKRAVIALAVQGDKIFTSGEDRLMMMVDRRNFSKPVLFEYSPTAYKSCLSLQCNQLLTSTSDGKVKLYDANNFNVLQTYSVGSYTRQSFLEHGAHLIMARSLKRNYTFSIYSPGTRSQQWCASHELAAEPAKFDYSPSSRTLAIGNGDSSILFCLPASAPDQEN |
| Enzyme Length | 406 |
| Uniprot Accession Number | Q22071 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Plays a role in mechanosensory transduction (touch sensitivity), touch receptor neuron development and synapse formation (PubMed:8692859, PubMed:19652181). Regulates expression of the protein snb-1 and the distribution of synaptic vesicles at synapses to promote synaptic transmission at the neuromuscular junctions of GABAergic motor neurons (PubMed:23527112). {ECO:0000269|PubMed:19652181, ECO:0000269|PubMed:23527112, ECO:0000269|PubMed:8692859}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Domain (1); Repeat (5) |
| Keywords | Reference proteome;Repeat;WD repeat |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Perikaryon {ECO:0000269|PubMed:23527112}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 21085631; 21177967; 21367940; 22286215; 23800452; 25359212; 25487147; 2646709; 32467239; |
| Motif | |
| Gene Encoded By | |
| Mass | 46,173 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |