Detail Information for IndEnz0010000954
IED ID IndEnz0010000954
Enzyme Type ID esterase000954
Protein Name HTH-type transcriptional regulator GbdR
Glycine betaine/dimethylglycine responsive regulator
Gene Name gbdR PA14_71070
Organism Pseudomonas aeruginosa (strain UCBPP-PA14)
Taxonomic Lineage cellular organisms Bacteria Proteobacteria Gammaproteobacteria Pseudomonadales Pseudomonadaceae Pseudomonas Pseudomonas aeruginosa group Pseudomonas aeruginosa Pseudomonas aeruginosa (strain UCBPP-PA14)
Enzyme Sequence MTTYAPGVPPQNRNPQSIGFLLLDNFTLISLASAVEPLRMANQLSGRELYRWHTLSLDGRQVWASDGLQITPDAGTDNAPAVDCVIVCGGVGIQRSVTREHVTFLQAQARQGRRLGAVCTGSWALARAGLLDGYDCSVHWECLAAMQEAFPRVAMSTRLFSIDRNRFTSSGGTAPMDMMLHLIGREHGRELSAAISEMFIYERIRNEQDHQRVPLKHMLGTNQPKLQEIVALMEANLEEPIDLDELAVYVNVSRRQLERLFQKYLHCSPSRYYLKLRLIRARQLLKQTSMSIIEVASVCGFVSTPHFSKCYREYFGIPPRDERQGQPLGQPVVLMPIPQDLALMPNSSALSALSQAQGESTFASVRI
Enzyme Length 367
Uniprot Accession Number A0A0H2ZIC3
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity
DNA Binding DNA_BIND 244..265; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00593; DNA_BIND 292..315; /note=H-T-H motif; /evidence=ECO:0000255|PROSITE-ProRule:PRU00593
EC Number
Enzyme Function FUNCTION: Specific regulator of choline metabolism, which activates transcription of at least 25 genes from 11 promoters in response to choline metabolites (PubMed:24097953). Required for the induction of plcH, encoding the phospholipase C, and pchP, encoding the phosphorylcholine phosphatase, in response to glycine betaine (GB) and dimethylglycine (DMG) (PubMed:19103776). Also controls the expression of gbcAB and dgcAB, which are required for GB and DMG degradation, respectively, in response to both GB and DMG (PubMed:17951379). The GbdR regulon also includes genes encoding sarcosine, glycine and serine catabolic enzymes, the BetX and CbcXWV quaternary amine transport proteins and the acetylcholine esterase gene, choE (PubMed:24097953). Acts by binding directly to the promoter region of the genes (PubMed:24097953). May play an important role during P.aeruginosa interactions with eukaryotes (PubMed:17951379). {ECO:0000269|PubMed:17951379, ECO:0000269|PubMed:19103776, ECO:0000269|PubMed:24097953}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); DNA binding (2); Domain (1)
Keywords Activator;DNA-binding;Transcription;Transcription regulation
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 41,000
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda