| IED ID |
IndEnz0010000988 |
| Enzyme Type ID |
esterase000988 |
| Protein Name |
Lissencephaly-1 homolog
|
| Gene Name |
pafah1b1 lis1 GSTENG00033355001 |
| Organism |
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) |
| Taxonomic Lineage |
cellular organisms
Eukaryota
Opisthokonta
Metazoa
Eumetazoa
Bilateria
Deuterostomia
Chordata
Craniata
Vertebrata
Gnathostomata (jawed vertebrates)
Teleostomi
Euteleostomi
Actinopterygii
Actinopteri
Neopterygii
Teleostei
Osteoglossocephalai
Clupeocephala
Euteleosteomorpha
Neoteleostei
Eurypterygia
Ctenosquamata
Acanthomorphata
Euacanthomorphacea
Percomorphaceae
Eupercaria
Tetraodontiformes (pufferfishes and others)
Tetraodontoidei
Tetradontoidea
Tetraodontidae (puffers)
Tetraodon
Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis)
|
| Enzyme Sequence |
MVLSQRQRDELNRAIADYLRSNGYEEAYSTFKKEAELDNNEELDKKYAGLLEKKWTSVIRLQKKVMELESKLNEAKEEITLGGPVSQKRDPKEWIPRPPERYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDLTGKLLASCSADMTIKLWDFQSFECIRTMHGHDHNVSSVAIMPNGDHIISASRDKTMKMWEVATGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELREHEHVVECISWAPESAHPTILDATSSESKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGKFIVTCADDKTLRIWDYKNKRCMKTLCAHEHFVTSLDFHKAAPYVVTGSVDQTVKVWECR |
| Enzyme Length |
410 |
| Uniprot Accession Number |
Q4RJN5 |
| Absorption |
|
| Active Site |
|
| Activity Regulation |
|
| Binding Site |
|
| Calcium Binding |
|
| catalytic Activity |
|
| DNA Binding |
|
| EC Number |
|
| Enzyme Function |
FUNCTION: Regulatory subunit (beta subunit) of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)), an enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and participates in the PAF inactivation (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. {ECO:0000250|UniProtKB:P43033, ECO:0000255|HAMAP-Rule:MF_03141}. |
| Temperature Dependency |
|
| PH Dependency |
|
| Pathway |
|
| nucleotide Binding |
|
| Features |
Chain (1); Coiled coil (1); Domain (1); Initiator methionine (1); Repeat (7) |
| Keywords |
Cell cycle;Cell division;Coiled coil;Cytoplasm;Cytoskeleton;Developmental protein;Differentiation;Microtubule;Mitosis;Neurogenesis;Reference proteome;Repeat;Transport;WD repeat |
| Interact With |
|
| Induction |
|
| Subcellular Location |
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03141}. Note=Localizes to the plus end of microtubules and to the centrosome. {ECO:0000255|HAMAP-Rule:MF_03141}. |
| Modified Residue |
|
| Post Translational Modification |
|
| Signal Peptide |
|
| Structure 3D |
|
| Cross Reference PDB |
- |
| Mapped Pubmed ID |
- |
| Motif |
|
| Gene Encoded By |
|
| Mass |
46,665 |
| Kinetics |
|
| Metal Binding |
|
| Rhea ID |
|
| Cross Reference Brenda |
|