| IED ID | IndEnz0010001069 |
| Enzyme Type ID | esterase001069 |
| Protein Name |
Carboxylesterase notum2 EC 3.1.1.- |
| Gene Name | notum2 |
| Organism | Danio rerio (Zebrafish) (Brachydanio rerio) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Actinopterygii Actinopteri Neopterygii Teleostei Osteoglossocephalai Clupeocephala Otomorpha Ostariophysi Otophysi Cypriniphysae Cypriniformes (carps and others) Cyprinoidei Danionidae Danioninae Danio Danio rerio (Zebrafish) (Brachydanio rerio) |
| Enzyme Sequence | MNIFCHALFLLLLGVVSCQNNNRNVKPGGKPAKKPNNPAIEATQHGPEADPNSGLAGAGDSSKETNPGGRGSSQQSASVNKPADDMKLHFLKNTAVTCNDGTAAGFYLKEFKGSKRWLIFLEGGWCCYSKETCDSRYKTIPRLMGSTDWPQTRRGSGLLSAQVDENPHWYNANIVFVPYCSSDVWSGNKAASKPKQGKETEYAFMGSQIIREVIKDLVPKGLKQAKVVMLAGTSAGGTGVLLNIDKVSSLLEQQGAEAQVRGLVDSGWFLESKQQKVPDCPDSASCTPADAIKKGLRLWNGVVPEKCKQQYKRGEDWHCFFGHKLYSYISAPLFVVQWLFDEEQLRVENIYMGSQSLSEQQWTYMQNLGKELKNSLKDVTAVFAPSCLSHTLITKSNWTDFQIKGTSLSRALQCWDRSFQEANKNSKTALKGCPFHLIDNCQWPQCNPTCPALIDQATQQEMTLLQVLASMGLDLQKLGLDVRGDISAGMVSNGG |
| Enzyme Length | 495 |
| Uniprot Accession Number | E7F0Z8 |
| Absorption | |
| Active Site | ACT_SITE 234; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:Q6P988; ACT_SITE 341; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:Q6P988; ACT_SITE 390; /note=Charge relay system; /evidence=ECO:0000250|UniProtKB:Q6P988 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.1.- |
| Enzyme Function | FUNCTION: Carboxylesterase that mediates deacylation of target proteins (By similarity). Acts as a regulator of growth cone migration. Does not act as an inhibitor of Wnt signaling (PubMed:23365253). {ECO:0000250|UniProtKB:Q6P988, ECO:0000269|PubMed:23365253}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Compositional bias (1); Glycosylation (1); Region (1); Signal peptide (1) |
| Keywords | Glycoprotein;Hydrolase;Reference proteome;Secreted;Serine esterase;Signal |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VUX3}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | SIGNAL 1..18; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 22669824; 31053140; |
| Motif | |
| Gene Encoded By | |
| Mass | 54,411 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |