Detail Information for IndEnz0010001106
IED ID IndEnz0010001106
Enzyme Type ID esterase001106
Protein Name Teichoic acid D-alanine hydrolase
EC 3.1.1.103
Teichoic acid D-alanine esterase
Gene Name fmtA fmt SAV1057
Organism Staphylococcus aureus (strain Mu50 / ATCC 700699)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus aureus Staphylococcus aureus (strain Mu50 / ATCC 700699)
Enzyme Sequence MKFNKVKLVIHACVLLFIIISIALIFHRLQTKTHSIDPIHKETKLSDNEKYLVDRNKEKVAPSKLKEVYNSKDPKYKKIDKYLQSSLFNGSVAIYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYLPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVKAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHTAFYDEQPFKKYLAKGYAYNSTGLSFLRPNILDQYYGAGNLYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKQYPDEYRYGFYAKPTLNRLNGGFFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
Enzyme Length 397
Uniprot Accession Number Q7A2T0
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=((4-D-Ala)-(2-GlcNAc)-Rib-ol-P)(n)-(Gro-P)(m)-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H(2)O = ((2-GlcNAc)-Rib-ol-P)(n)-(Gro-P)(m)-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine.; EC=3.1.1.103; Evidence={ECO:0000269|PubMed:26861022};
DNA Binding
EC Number 3.1.1.103
Enzyme Function FUNCTION: Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA) (PubMed:26861022). Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure (PubMed:22564846). {ECO:0000269|PubMed:22564846, ECO:0000269|PubMed:26861022}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Signal peptide (1)
Keywords Antibiotic resistance;Cell membrane;Cell wall biogenesis/degradation;Hydrolase;Membrane;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..23; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 46,067
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda