Detail Information for IndEnz0010001235
IED ID IndEnz0010001235
Enzyme Type ID esterase001235
Protein Name Teichoic acid D-alanine hydrolase
EC 3.1.1.103
Teichoic acid D-alanine esterase
Gene Name fmtA fmt SAR1030
Organism Staphylococcus aureus (strain MRSA252)
Taxonomic Lineage cellular organisms Bacteria Terrabacteria group Firmicutes Bacilli Bacillales Staphylococcaceae Staphylococcus Staphylococcus aureus Staphylococcus aureus (strain MRSA252)
Enzyme Sequence MKFNKEKLVIHACVLLFIIISIGLVFHRLQTKTNSIEPIHKETKLSDNAKYLVDRNKGKGEPSKLKEVYNSKDPKYKKIDRYLQNSLFNGSVAVYENGKLKMSKGYGYQDFEKGIKNTPNTMFLIGSAQKFSTGLLLKQLEEEHKININDPVSKYIPWFKTSKPIPLKDLMLHQSGLYKYKSSKDYKNLDQAVRAIQKRGIDPKKYKKHMYNDGNYLVLAKVIEEVTGKSYAENYYTKIGDPLKLQHSAFYDEKSFRKYFAKGYSYNSTGLSFLKPNVLEQYYGAGNIYMTPTDMGKLITQIQQYKLFSPKITNPLLHEFGTKQYPDEYRYGFYVKPTLNRLNGGLFGQVFTVYYNDKYVVVLALNVKGNNEVRIKHIYNDILKQNKPYNTKGVIVQ
Enzyme Length 397
Uniprot Accession Number Q6GI27
Absorption
Active Site
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=((4-D-Ala)-(2-GlcNAc)-Rib-ol-P)(n)-(Gro-P)(m)-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H(2)O = ((2-GlcNAc)-Rib-ol-P)(n)-(Gro-P)(m)-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine.; EC=3.1.1.103; Evidence={ECO:0000250|UniProtKB:Q7A2T0};
DNA Binding
EC Number 3.1.1.103
Enzyme Function FUNCTION: Catalyzes the liberation of D-alanyl moieties present on wall teichoic acid (WTA) and lipoteichoic acid (LTA). Affects the methicillin resistance level and autolysis in the presence of Triton X-100 as well as the cell wall structure. {ECO:0000250|UniProtKB:Q7A2T0}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Chain (1); Signal peptide (1)
Keywords Antibiotic resistance;Cell membrane;Cell wall biogenesis/degradation;Hydrolase;Membrane;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Modified Residue
Post Translational Modification
Signal Peptide SIGNAL 1..27; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 46,035
Kinetics
Metal Binding
Rhea ID
Cross Reference Brenda