Detail Information for IndEnz0010001329
IED ID IndEnz0010001329
Enzyme Type ID esterase001329
Protein Name Carboxylesterase 3
EC 3.1.1.1
Liver carboxylesterase 31 homolog
Gene Name CES3
Organism Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Ponginae Pongo Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Enzyme Sequence MRLHRLRARLNAVAFGLLLLLVHGQGPEIVQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASAAPPMCLQDVESMNNSRFVLNGKQQIFSVSEDCLVLNIYSPAEATAGAGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQGNITPFGGDLNCVTVFGGSAGGSIVSGLVLSPMAAGLFHRAITQSGVITTPGIIESHPWPLAQKITNTLACSSSSPAEMVQCLRQKEGEELVLSKKLKSTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCLAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHAAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKGLPPWPRFNQAEQYLEINPVPRAGQKFRETRMQFWSETLPSKIQQWHQKQKNRKAQEDL
Enzyme Length 569
Uniprot Accession Number Q5RCL7
Absorption
Active Site ACT_SITE 227; /note=Acyl-ester intermediate; /evidence=ECO:0000255|PROSITE-ProRule:PRU10039; ACT_SITE 345; /note=Charge relay system; /evidence=ECO:0000250; ACT_SITE 458; /note=Charge relay system; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=a carboxylic ester + H2O = a carboxylate + an alcohol + H(+); Xref=Rhea:RHEA:21164, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:30879, ChEBI:CHEBI:33308; EC=3.1.1.1; Evidence={ECO:0000255|PROSITE-ProRule:PRU10039};
DNA Binding
EC Number 3.1.1.1
Enzyme Function FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Disulfide bond (2); Glycosylation (1); Motif (1); Sequence conflict (6); Signal peptide (1)
Keywords Disulfide bond;Endoplasmic reticulum;Glycoprotein;Hydrolase;Reference proteome;Serine esterase;Signal
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
Modified Residue
Post Translational Modification PTM: N-glycosylated.
Signal Peptide SIGNAL 1..24; /evidence=ECO:0000255
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif MOTIF 566..569; /note=Prevents secretion from ER; /evidence=ECO:0000255
Gene Encoded By
Mass 62,439
Kinetics
Metal Binding
Rhea ID RHEA:21164
Cross Reference Brenda