| IED ID | IndEnz0010001514 |
| Enzyme Type ID | esterase001514 |
| Protein Name |
Protein phosphatase methylesterase 1 PME-1 EC 3.1.1.89 |
| Gene Name | ppe1 AFUA_1G03080 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MSDLHKAFAKSKLAKLPPEAPLLSESSSMNHPAESSHDEDSSSVSSTGTVIPSPSRQLFARASQGSSDSSSLSWSDFFAKELFLTRETDTLRIIHHVYLTPPTDSGPLFVMHHGAGSSGLSFATCAEEIRKILPKAGILSLDARDHGRTSVQRTDGGAAELDLSLETLNQDLVYVARKTQAEMGWEELPDLVLVGHSLGGAVITDVAKKGELGNKVLAYAVLDVVEGSAMDALQSMEKYLSTRPSRFPSLTSGVEWHTRSRTIRNRASARVSVPSLLYKEETPSDPAKPWVWRTNLSATKPFWEDWFIGLSRKFLEARGGKLLLLAGTDRLDKELMIGQMQGKYQLQVLPEAGHFIQEDMPAKTAQILVDFYKRNDRSALVLPPKVADMRASAAMQKGAGAGASFSALHGGSSAGHLHKP |
| Enzyme Length | 420 |
| Uniprot Accession Number | Q4WKB2 |
| Absorption | |
| Active Site | ACT_SITE 197; /evidence=ECO:0000250; ACT_SITE 223; /evidence=ECO:0000250; ACT_SITE 354; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; |
| DNA Binding | |
| EC Number | 3.1.1.89 |
| Enzyme Function | FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Region (1) |
| Keywords | Hydrolase;Reference proteome;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,619 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:48548 |
| Cross Reference Brenda |