| IED ID | IndEnz0010001551 |
| Enzyme Type ID | esterase001551 |
| Protein Name |
Fusarinine C esterase sidJ EC 3.1.-.- |
| Gene Name | sidJ AFUA_3G03390 |
| Organism | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Pezizomycotina leotiomyceta Eurotiomycetes Eurotiomycetidae Eurotiales (green and blue molds) Aspergillaceae Aspergillus Aspergillus subgen. Fumigati Neosartorya fumigata (Aspergillus fumigatus) Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
| Enzyme Sequence | MYSKFWPKGGLPGILHHYTETLVTFEYTTTTTRKPHSLLFVGGLGDGLATTSYLADLAHALQPTEWSLFTLTLTSSYQSWGLGHLDRDTNEIAQCLKYIKEYKTEKFGGSASSGKIVLMGHSTGSQCVLHYLSRPNPHTHTPAFDPYLEHVERMPLDGAIMQAPVSDREAIQWVLAEGLGDRTPAEIRPVFEKLTSMAREAARDADAGTDVLLPLAMTSLVYPAHTPLSARRFLSLTSPESPESPSEDDLFSSDLSDEQLGKTFGMIREQGLLRGKLMVLFSGADQSVPAWVDKDTLLSRWRNATDHNGEAAIWDENSGIIPNASHALSNDDQAEPRNFLVNKVLGYLSALVKA |
| Enzyme Length | 354 |
| Uniprot Accession Number | Q4WF56 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.1.-.- |
| Enzyme Function | FUNCTION: Displays specific fusarinine C (FsC) esterase activity but does not hydrolyze triacetylfusarinine C (TAFC), which has the same core structure as fusarinine C (PubMed:24038704). Both extra- and intracellular siderophores have been shown to be crucial for the virulence (PubMed:24038704). Subsequent to chelation of iron and uptake, FsC and TAFC are hydrolyzed and the iron is transferred to the metabolism or to the intracellular siderophore ferricrocin (FC) for transport and storage of iron (PubMed:24038704). {ECO:0000269|PubMed:24038704}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Beta strand (10); Chain (1); Helix (13); Turn (1) |
| Keywords | 3D-structure;Hydrolase;Reference proteome |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | X-ray crystallography (1) |
| Cross Reference PDB | 6GUP; |
| Mapped Pubmed ID | 30070018; |
| Motif | |
| Gene Encoded By | |
| Mass | 38,962 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |