| IED ID | IndEnz0010001591 |
| Enzyme Type ID | esterase001591 |
| Protein Name |
Probable O-acetyltransferase CAS1 EC 2.3.1.- Capsule synthesis protein 1 |
| Gene Name | CAS1 CNN01530 |
| Organism | Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans) |
| Enzyme Sequence | MPNSSKPRSQASAAKLNPLWYTYACATLVAAVVLGNILRWAFLELPDSYHCSALLNTGKWLDPGTWTNWQPEGCFQLPLSAQSWQKCLASPTVNTHQALHSSYYDKRTALFVGDSTVRQLYFAAARKVGKTSKAWELEGEKHTDRSLLVSDPLGGPSLELEFWWDPYLNSSKTIGLLSGQSSVPSSLLVMGSGLWYLRNPSSGGLASWGAMIYDTFELVKKNQGSPQTALINPWDNMLLGPGITLPGLLPNQPPKFVDHSREVEARSLFSRASSISHRPTDFSISDAIVFLPISTPVREKLSPSRAETIFHTDVEAMNADLYARLTHPDPPPVVIPSVLNQLLVDDETEDGLHFSDKIMNKQAELLLSWRCNDVMRHEGATGTCCKRYDWVTPIQGLILAVLILWAPLGTFITPRLPPNSPILDYLPATSIAPALSTFGLAMGYLFLADRTHVFQKEQKDYDAVIFGMITLAAFVAGLLTIKNSGKDLGFLNRDITDEWKGWMQIAILIYHFFGASKISGIYNPIRVLVASYLFMTGYGHFFFYYKKADFGFQRVVMVLVRLNLLSVVLPYTMNTDYAFYYFAPLVSWWYLIIYATMAIGSKYNDRPAFLLTKLFTCAGLVTLFMHFPWLMEDVFKVLNTVFNIQWSAKEWSFRVTLDLFIVWVGMLCAYGFVKFNEHQISDRPWFPVMRTATLVGSVLGMIWYFWFELHLASKFVYNEYHAVVCIVPIMSFVFLRNASPVLRSSTSKIFCFIGQCSLETFILQFHGWLASDTKAILLAVPSTQWRPVNLVISTICFIWLSYRVSGATGEITEWLVGKKKALPLPATSANSSTSPGRQATSPTLTSASAMQAVVVGPQDGAKGGIPESIPMMNQADKDIGGLTPMEDETLERRDSWPTWMASTAASLTGRTVEGYAPLTRRWKDQTVLSVIQNLGDLMKKHNSVKIAVILLGLWALNWIY |
| Enzyme Length | 960 |
| Uniprot Accession Number | P0CM56 |
| Absorption | |
| Active Site | ACT_SITE 115; /note=Acyl-ester intermediate; /evidence=ECO:0000250|UniProtKB:Q96PB1; ACT_SITE 350; /evidence=ECO:0000250|UniProtKB:Q96PB1; ACT_SITE 353; /evidence=ECO:0000250|UniProtKB:Q96PB1 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 2.3.1.- |
| Enzyme Function | FUNCTION: Probable O-acetyltransferase required for the O-acetylation of the capsular glucoronoxylmannans (GXM) involved in virulence. {ECO:0000269|PubMed:11703667, ECO:0000269|PubMed:12139628, ECO:0000269|PubMed:12704160, ECO:0000269|PubMed:15004170}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Glycosylation (3); Transmembrane (13) |
| Keywords | Glycoprotein;Membrane;Oxidoreductase;Reference proteome;Transferase;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 107,504 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |