IED Industry Enzyme Database

Detail Information for IndEnz0010001599
IED ID IndEnz0010001599
Enzyme Type ID esterase001599
Protein Name Carbonic anhydrase 2
EC 4.2.1.1
Carbonate dehydratase II
Carbonic anhydrase C
CAC
Carbonic anhydrase II
CA-II
Cyanamide hydratase CA2
EC 4.2.1.69
Gene Name CA2
Organism Homo sapiens (Human)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Mammalia Theria Eutheria Boreoeutheria Euarchontoglires Primates Haplorrhini Simiiformes Catarrhini Hominoidea (apes) Hominidae (great apes) Homininae Homo Homo sapiens (Human)
Enzyme Sequence MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
Enzyme Length 260
Uniprot Accession Number P00918
Absorption
Active Site ACT_SITE 64; /note="Proton donor/acceptor"; /evidence="ECO:0000305|PubMed:15667203, ECO:0000305|PubMed:17330962"
Activity Regulation ACTIVITY REGULATION: Activated by X-ray, histamine, L-adrenaline, L- and D-phenylalanine, L- and D-histidine, L-His-OMe and beta-Ala-His (carnosine). Competitively inhibited by saccharin, thioxolone, coumarins, 667-coumate, celecoxib (Celebrex), valdecoxib (Bextra), SC-125, SC-560, diclofenac, acetate, azide, bromide, sulfonamide derivatives such as acetazolamide (AZA), methazolamide (MZA), ethoxzolamide (EZA), dichlorophenamide (DCP), brinzolamide, dansylamide, thiabendazole-5-sulfonamide, trifluoromethane sulfonamide and N-hydroxysulfamide, fructose-based sugar sulfamate RWJ-37497, and Foscarnet (phosphonoformate trisodium salt). Repressed strongly by hydrogen sulfide(HS) and weakly by nitrate (NO(3)). Esterase activity weakly reduced by cyanamide. N-hydroxyurea interfers with zinc binding and inhibit activity. {ECO:0000269|PubMed:11802772, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:14736236, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:16290146, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16759856, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17540563, ECO:0000269|PubMed:17588751, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18024029, ECO:0000269|PubMed:18162396, ECO:0000269|PubMed:18266323, ECO:0000269|PubMed:18374572, ECO:0000269|PubMed:18481843, ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:18640037, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:19170619, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19520834, ECO:0000269|PubMed:19778001, ECO:0000269|PubMed:9265618}.
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; Evidence={ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}; CATALYTIC ACTIVITY: Reaction=urea = cyanamide + H2O; Xref=Rhea:RHEA:23056, ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:16698; EC=4.2.1.69; Evidence={ECO:0000269|PubMed:10550681};
DNA Binding
EC Number 4.2.1.1; 4.2.1.69
Enzyme Function FUNCTION: Catalyzes the reversible hydration of carbon dioxide (PubMed:1909891, PubMed:1910042, PubMed:1336460, PubMed:8485129, PubMed:8399159, PubMed:8218160, PubMed:8262987, PubMed:8451242, PubMed:7901850, PubMed:7761440, PubMed:8639494, PubMed:9265618, PubMed:17330962, PubMed:9398308, PubMed:11327835, PubMed:12056894, PubMed:17346964, PubMed:12171926, PubMed:15453828, PubMed:16214338, PubMed:15865431, PubMed:16106378, PubMed:15300855, PubMed:15667203, PubMed:18942852, PubMed:11831900, PubMed:17251017). Can also hydrate cyanamide to urea (PubMed:10550681, PubMed:11015219). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (PubMed:15990874). Essential for bone resorption and osteoclast differentiation (PubMed:15300855). Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:11015219, ECO:0000269|PubMed:11327835, ECO:0000269|PubMed:11831900, ECO:0000269|PubMed:12056894, ECO:0000269|PubMed:12171926, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:15300855, ECO:0000269|PubMed:15453828, ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:15865431, ECO:0000269|PubMed:15990874, ECO:0000269|PubMed:16106378, ECO:0000269|PubMed:16214338, ECO:0000269|PubMed:17251017, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:17346964, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:1910042, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8485129, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:9265618, ECO:0000269|PubMed:9398308}.
Temperature Dependency
PH Dependency BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6-8. {ECO:0000269|PubMed:15667203, ECO:0000269|PubMed:17330962, ECO:0000269|PubMed:18942852, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:9398308};
Pathway
nucleotide Binding
Features Active site (1); Beta strand (23); Chain (1); Domain (1); Helix (9); Initiator methionine (1); Metal binding (3); Modified residue (4); Mutagenesis (37); Natural variant (7); Region (1); Sequence conflict (1); Site (4); Turn (5)
Keywords 3D-structure;Acetylation;Cell membrane;Cytoplasm;Direct protein sequencing;Disease variant;Lyase;Membrane;Metal-binding;Osteopetrosis;Phosphoprotein;Reference proteome;Zinc
Interact With
Induction
Subcellular Location SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15990874}. Cell membrane {ECO:0000269|PubMed:15990874}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000269|PubMed:15990874}.
Modified Residue MOD_RES 2; /note="N-acetylserine"; /evidence="ECO:0000269|PubMed:4207120, ECO:0000269|PubMed:823150"; MOD_RES 2; /note="Phosphoserine"; /evidence="ECO:0000250|UniProtKB:P27139"; MOD_RES 165; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:24275569"; MOD_RES 172; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:24275569"
Post Translational Modification
Signal Peptide
Structure 3D X-ray crystallography (956); NMR spectroscopy (2); Neutron diffraction (4); Electron microscopy (2)
Cross Reference PDB 12CA; 1A42; 1AM6; 1AVN; 1BCD; 1BIC; 1BN1; 1BN3; 1BN4; 1BNM; 1BNN; 1BNQ; 1BNT; 1BNU; 1BNV; 1BNW; 1BV3; 1CA2; 1CA3; 1CAH; 1CAI; 1CAJ; 1CAK; 1CAL; 1CAM; 1CAN; 1CAO; 1CAY; 1CAZ; 1CCS; 1CCT; 1CCU; 1CIL; 1CIM; 1CIN; 1CNB; 1CNC; 1CNG; 1CNH; 1CNI; 1CNJ; 1CNK; 1CNW; 1CNX; 1CNY; 1CRA; 1CVA; 1CVB; 1CVC; 1CVD; 1CVE; 1CVF; 1CVH; 1DCA; 1DCB; 1EOU; 1F2W; 1FQL; 1FQM; 1FQN; 1FQR; 1FR4; 1FR7; 1FSN; 1FSQ; 1FSR; 1G0E; 1G0F; 1G1D; 1G3Z; 1G45; 1G46; 1G48; 1G4J; 1G4O; 1G52; 1G53; 1G54; 1H4N; 1H9N; 1H9Q; 1HCA; 1HEA; 1HEB; 1HEC; 1HED; 1HVA; 1I8Z; 1I90; 1I91; 1I9L; 1I9M; 1I9N; 1I9O; 1I9P; 1I9Q; 1IF4; 1IF5; 1IF6; 1IF7; 1IF8; 1IF9; 1KWQ; 1KWR; 1LG5; 1LG6; 1LGD; 1LUG; 1LZV; 1MOO; 1MUA; 1OKL; 1OKM; 1OKN; 1OQ5; 1RAY; 1RAZ; 1RZA; 1RZB; 1RZC; 1RZD; 1RZE; 1T9N; 1TB0; 1TBT; 1TE3; 1TEQ; 1TEU; 1TG3; 1TG9; 1TH9; 1THK; 1TTM; 1UGA; 1UGB; 1UGC; 1UGD; 1UGE; 1UGF; 1UGG; 1XEG; 1XEV; 1XPZ; 1XQ0; 1YDA; 1YDB; 1YDC; 1YDD; 1YO0; 1YO1; 1YO2; 1Z9Y; 1ZE8; 1ZFK; 1ZFQ; 1ZGE; 1ZGF; 1ZH9; 1ZSA; 1ZSB; 1ZSC; 2ABE; 2AW1; 2AX2; 2CA2; 2CBA; 2CBB; 2CBC; 2CBD; 2CBE; 2EU2; 2EU3; 2EZ7; 2F14; 2FMG; 2FMZ; 2FNK; 2FNM; 2FNN; 2FOQ; 2FOS; 2FOU; 2FOV; 2GD8; 2GEH; 2H15; 2H4N; 2HD6; 2HKK; 2HL4; 2HNC; 2HOC; 2ILI; 2NNG; 2NNO; 2NNS; 2NNV; 2NWO; 2NWP; 2NWY; 2NWZ; 2NXR; 2NXS; 2NXT; 2O4Z; 2OSF; 2OSM; 2POU; 2POV; 2POW; 2Q1B; 2Q1Q; 2Q38; 2QO8; 2QOA; 2QP6; 2VVA; 2VVB; 2WD2; 2WD3; 2WEG; 2WEH; 2WEJ; 2WEO; 2X7S; 2X7T; 2X7U; 3B4F; 3BET; 3BL0; 3BL1; 3C7P; 3CA2; 3CAJ; 3CYU; 3D8W; 3D92; 3D93; 3D9Z; 3DAZ; 3DBU; 3DC3; 3DC9; 3DCC; 3DCS; 3DCW; 3DD0; 3DD8; 3DV7; 3DVB; 3DVC; 3DVD; 3EFI; 3EFT; 3F4X; 3F8E; 3FFP; 3GZ0; 3HFP; 3HKN; 3HKQ; 3HKT; 3HKU; 3HLJ; 3HS4; 3IBI; 3IBL; 3IBN; 3IBU; 3IEO; 3IGP; 3K2F; 3K34; 3K7K; 3KIG; 3KKX; 3KNE; 3KOI; 3KOK; 3KON; 3KS3; 3KWA; 3L14; 3M04; 3M14; 3M1J; 3M1K; 3M1Q; 3M1W; 3M2N; 3M2X; 3M2Y; 3M2Z; 3M3X; 3M40; 3M5E; 3M5S; 3M5T; 3M67; 3M96; 3M98; 3MHC; 3MHI; 3MHL; 3MHM; 3MHO; 3ML2; 3MMF; 3MNA; 3MNH; 3MNI; 3MNJ; 3MNK; 3MNU; 3MWO; 3MYQ; 3MZC; 3N0N; 3N2P; 3N3J; 3N4B; 3NB5; 3NI5; 3NJ9; 3OIK; 3OIL; 3OIM; 3OKU; 3OKV; 3OY0; 3OYQ; 3OYS; 3P3H; 3P3J; 3P44; 3P4V; 3P55; 3P58; 3P5A; 3P5L; 3PJJ; 3PO6; 3PYK; 3QYK; 3R16; 3R17; 3RG3; 3RG4; 3RGE; 3RJ7; 3RLD; 3RYJ; 3RYV; 3RYX; 3RYY; 3RYZ; 3RZ0; 3RZ1; 3RZ5; 3RZ7; 3RZ8; 3S71; 3S72; 3S73; 3S74; 3S75; 3S76; 3S77; 3S78; 3S8X; 3S9T; 3SAP; 3SAX; 3SBH; 3SBI; 3T5U; 3T5Z; 3T82; 3T83; 3T84; 3T85; 3TMJ; 3TVN; 3TVO; 3U3A; 3U45; 3U47; 3U7C; 3V2J; 3V2M; 3V3F; 3V3G; 3V3H; 3V3I; 3V3J; 3V5G; 3V7X; 3VBD; 3ZP9; 4BCW; 4BF1; 4BF6; 4CA2; 4CAC; 4CQ0; 4DZ7; 4DZ9; 4E3D; 4E3F; 4E3G; 4E3H; 4E49; 4E4A; 4E5Q; 4FIK; 4FL7; 4FPT; 4FRC; 4FU5; 4FVN; 4FVO; 4G0C; 4GL1; 4HBA; 4HEW; 4HEY; 4HEZ; 4HF3; 4HT0; 4IDR; 4ILX; 4ITO; 4ITP; 4IWZ; 4JS6; 4JSA; 4JSS; 4JSW; 4JSZ; 4K0S; 4K0T; 4K0Z; 4K13; 4K1Q; 4KAP; 4KNI; 4KNJ; 4KUV; 4KUW; 4KUY; 4KV0; 4L5U; 4L5V; 4L5W; 4LHI; 4LP6; 4M2R; 4M2U; 4M2V; 4M2W; 4MDG; 4MDL; 4MDM; 4MLT; 4MLX; 4MO8; 4MTY; 4N0X; 4N16; 4PQ7; 4PXX; 4PYX; 4PYY; 4PZH; 4Q06; 4Q07; 4Q08; 4Q09; 4Q49; 4Q6D; 4Q6E; 4Q78; 4Q7P; 4Q7S; 4Q7V; 4Q7W; 4Q81; 4Q83; 4Q87; 4Q8X; 4Q8Y; 4Q8Z; 4Q90; 4Q99; 4Q9Y; 4QEF; 4QIY; 4QJM; 4QK1; 4QK2; 4QK3; 4QSA; 4QSB; 4QSI; 4QTL; 4QY3; 4R59; 4R5A; 4R5B; 4RFC; 4RFD; 4RH2; 4RIU; 4RIV; 4RN4; 4RUX; 4RUY; 4RUZ; 4WL4; 4WW6; 4XE1; 4Y0J; 4YGJ; 4YGK; 4YGL; 4YGN; 4YVY; 4YWP; 4YX4; 4YXI; 4YXO; 4YXU; 4YYT; 4Z0Q; 4Z1E; 4Z1J; 4Z1K; 4Z1N; 4ZAO; 4ZWI; 4ZWX; 4ZWY; 4ZWZ; 4ZX0; 4ZX1; 5A6H; 5AMD; 5AMG; 5AML; 5BNL; 5BRU; 5BRV; 5BRW; 5BYI; 5C8I; 5CA2; 5CAC; 5CLU; 5DOG; 5DOH; 5DRS; 5DSK; 5DSL; 5DSM; 5DSO; 5DSP; 5DSQ; 5DSR; 5E28; 5E2K; 5E2R; 5E2S; 5EH5; 5EH7; 5EH8; 5EHE; 5EHV; 5EHW; 5EIJ; 5EKH; 5EKJ; 5EKM; 5EOI; 5FDC; 5FDI; 5FLO; 5FLP; 5FLQ; 5FLR; 5FLS; 5FLT; 5FNG; 5FNH; 5FNI; 5FNJ; 5FNK; 5FNL; 5FNM; 5G01; 5G03; 5G0B; 5G0C; 5GMN; 5J8Z; 5JDV; 5JE7; 5JEG; 5JEH; 5JEP; 5JES; 5JG3; 5JG5; 5JGS; 5JGT; 5JMZ; 5JN3; 5JN7; 5JQ0; 5JQT; 5L3O; 5L6K; 5L6T; 5L70; 5L9E; 5LJQ; 5LJT; 5LL4; 5LL8; 5LLC; 5LLE; 5LLG; 5LLH; 5LMD; 5LVS; 5M78; 5MJN; 5N0D; 5N0E; 5N1R; 5N1S; 5N24; 5N25; 5NEA; 5NEE; 5NXG; 5NXI; 5NXM; 5NXO; 5NXP; 5NXV; 5NXW; 5NY1; 5NY3; 5NY6; 5NYA; 5O07; 5OGN; 5OGO; 5OGP; 5SZ0; 5SZ1; 5SZ2; 5SZ3; 5SZ4; 5SZ5; 5SZ6; 5SZ7; 5T71; 5T72; 5T74; 5T75; 5TFX; 5TH4; 5THI; 5THJ; 5THN; 5TI0; 5TXY; 5TY1; 5TY8; 5TY9; 5TYA; 5U0D; 5U0E; 5U0F; 5U0G; 5ULN; 5UMC; 5VGY; 5W8B; 5WEX; 5WG7; 5WGP; 5WLR; 5WLT; 5WLU; 5WLV; 5Y2R; 5Y2S; 5YUI; 5YUJ; 5YUK; 5ZXW; 6B4D; 6B59; 6B5A; 6BBS; 6BC9; 6BCC; 6C7W; 6C7X; 6CA2; 6CEH; 6CJV; 6D1L; 6D1M; 6E8P; 6E8X; 6E91; 6E92; 6EBE; 6ECZ; 6EDA; 6EEA; 6EEH; 6EEO; 6EQU; 6FJI; 6FJJ; 6G3Q; 6G6T; 6GCY; 6GDC; 6GM9; 6GOT; 6GXB; 6GXE; 6H29; 6H2Z; 6H33; 6H34; 6H3Q; 6H6S; 6HD2; 6HQX; 6HR3; 6HX5; 6HXD; 6HZX; 6I0W; 6I1U; 6I2F; 6I3E; 6IC2; 6KLZ; 6KM0; 6KM1; 6KM2; 6KM3; 6KM4; 6KM5; 6KM6; 6LUU; 6LUV; 6LUW; 6LUX; 6LUY; 6LUZ; 6LV1; 6LV2; 6LV3; 6LV4; 6LV5; 6LV6; 6LV7; 6LV8; 6LV9; 6LVA; 6MBV; 6MBY; 6NLV; 6NM0; 6ODZ; 6OE0; 6OE1; 6OTI; 6OTK; 6OTM; 6OTO; 6OTP; 6OTQ; 6OUB; 6OUD; 6OUE; 6OUF; 6OUH; 6OUI; 6OUJ; 6OUK; 6OUM; 6PDV; 6PEA; 6PGX; 6Q3O; 6Q9T; 6QEB; 6QL1; 6QL2; 6QL3; 6R6F; 6R6J; 6RFH; 6RG3; 6RG4; 6RG5; 6RH4; 6RHJ; 6RHK; 6RIG; 6RIT; 6RJJ; 6RKN; 6RL9; 6RM1; 6RMP; 6RMX; 6RMY; 6RNP; 6ROB; 6ROE; 6ROF; 6RQI; 6RRG; 6RRI; 6RS5; 6RSZ; 6RVF; 6RVK; 6RVL; 6RW1; 6RZX; 6S03; 6S9G; 6S9Z; 6SAC; 6SAS; 6SAY; 6SB7; 6SBH; 6SBL; 6SBM; 6SD7; 6SDH; 6SDI; 6SDJ; 6SDL; 6SDS; 6SEY; 6SFQ; 6SFU; 6SG0; 6SG6; 6SX9; 6SYB; 6SYS; 6T4N; 6T4O; 6T4P; 6T5C; 6T7U; 6T81; 6T9Z; 6U4Q; 6U4T; 6UFB; 6UFC; 6UFD; 6UGN; 6UGO; 6UGP; 6UGQ; 6UGR; 6UGZ; 6UH0; 6UX1; 6UZU; 6VJ3; 6VKG; 6WKA; 6WQ4; 6WQ5; 6WQ7; 6WQ8; 6WQ9; 6XVH; 6XWZ; 6XXT; 6YH4; 6YH5; 6YH6; 6YH7; 6YH8; 6YH9; 6YHA; 6YHB; 6YHC; 6YJ3; 6YKC; 6YKH; 6YMA; 6YMB; 6YO2; 6YO4; 6YO7; 6YOI; 6YOK; 6YOL; 6YPW; 6YQT; 6YQU; 6YRI; 6YZJ; 6YZK; 6YZL; 6YZM; 6YZN; 6YZO; 6YZP; 6YZQ; 6YZR; 6YZS; 6YZT; 6YZU; 6YZV; 6YZW; 6YZX; 6Z04; 6ZR8; 7A6V; 7AEQ; 7AES; 7AGN; 7ASJ; 7BFA; 7BG5; 7BI5; 7CA2; 7JNR; 7JNV; 7JNW; 7JNX; 7JNZ; 7JO0; 7JO1; 7JO2; 7JO3; 7JOB; 7JOC; 7K6I; 7K6J; 7K6K; 7K6L; 7K6T; 7K6U; 7K6X; 7K6Z; 7MU3; 7ONV; 7Q0C; 7Q0E; 8CA2; 9CA2;
Mapped Pubmed ID 11956656; 120192; 12501217; 12826902; 12933803; 14675565; 15049705; 15062553; 1554744; 15836783; 15837316; 15837325; 16169070; 16265785; 16475831; 16687407; 16825953; 17202139; 17319695; 17363915; 17427958; 17631639; 17881426; 18060825; 18083150; 18189416; 18247480; 18323598; 18539591; 18580434; 18774300; 19012038; 19034380; 19269136; 19371798; 19407386; 19415900; 19465771; 19615732; 19634894; 19851004; 19854054; 19882701; 19911821; 20000378; 20005709; 20025241; 20028100; 20081808; 20148564; 20166809; 20170095; 20297840; 20349499; 20360068; 20386818; 20398423; 20445237; 20445238; 20472429; 20493921; 20509747; 20578724; 20590092; 20598552; 20605094; 20629007; 20634585; 20637176; 20693695; 20849852; 20889345; 20922253; 20926301; 20931644; 20976122; 21145876; 21243755; 21282642; 2128470; 21332115; 21395315; 21506176; 21506569; 21515057; 21543742; 21549597; 21620713; 21680735; 2169869; 21706094; 21790183; 21952494; 21958118; 21988105; 22001224; 22011572; 22192857; 22218610; 22258283; 22276570; 22344779; 22416960; 22440859; 22443141; 22531842; 22691706; 22732064; 22775345; 22836518; 22878862; 22928733; 23030313; 23098192; 23215152; 23241068; 23360090; 23394791; 234739; 23490152; 23674848; 23706138; 23727877; 23737439; 23788494; 23859774; 23897465; 23953824; 23993330; 24012377; 24036123; 24090602; 24103428; 24128000; 24288253; 24300919; 24307504; 24635441; 24670789; 24689792; 24813993; 24914985; 25019941; 25059669; 25075329; 25116076; 25165709; 25254302; 25258712; 25286933; 25309911; 25353386; 25358036; 25358084; 25400751; 25407638; 25493428; 25581127; 25609088; 25609649; 25614109; 25683338; 25720518; 25733161; 25738615; 25758852; 25766630; 25813715; 25902526; 26010488; 26041446; 26079542; 26093313; 26199669; 26203869; 26226626; 26266677; 26276436; 26457530; 26497049; 26507456; 26692420; 26698855; 26700575; 26741028; 26756542; 26810836; 26882437; 26970563; 27063577; 27114542; 27129464; 27151329; 27172398; 27232456; 27316543; 27475498; 27688658; 27722534; 27860128; 27892589; 27933963; 28001003; 28024887; 28170240; 28233447; 28252841; 28270370; 28389830; 28445001; 28453941; 28461893; 28544359; 28613396; 28728897; 28738704; 28817930; 28947941; 28947945; 29090039; 29139171; 29199489; 29259754; 29266943; 29309535; 29316128; 29354275; 29357237; 29423818; 29429876; 29503769; 29685656; 29795760; 29803994; 29809145; 29851481; 30006175; 30034596; 30066203; 30140816; 30193219; 30253337; 30344913; 30433782; 30470900; 30530195; 30560259; 30639924; 30688395; 30721041; 3080418; 30839290; 31038135; 31136893; 31257622; 31374520; 31401537; 31423863; 31481705; 31542996; 31568723; 31638225; 31740053; 31778702; 31794211; 31847904; 31978481; 32027480; 32031797; 32044580; 32088421; 32148856; 32230853; 32235320; 32244293; 32364386; 32435417; 32452709; 32463228; 32505851; 32519851; 32573627; 32737395; 32757220; 32917908; 32955786; 32962427; 32971003; 32992797; 33000794; 33085484; 33209313; 33303238; 33523653; 33555497; 33647799; 33662630; 33945229; 34328515; 34371130; 34636283; 34849402; 35008553; 35016406; 4994926; 6433979; 6819139; 8083199; 8399223; 9336012; 9635771;
Motif
Gene Encoded By
Mass 29,246
Kinetics BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=9.3 mM for CO(2) {ECO:0000269|PubMed:18618712, ECO:0000269|PubMed:7761440}; KM=11 mM for CO(2) {ECO:0000269|PubMed:1909891}; KM=8.2 mM for CO(2) {ECO:0000269|PubMed:9398308}; KM=82 mM for H(2)CO(3) {ECO:0000269|PubMed:8262987}; KM=2.9 mM for 4-nitrophenyl acetate {ECO:0000269|PubMed:10550681};
Metal Binding METAL 94; /note="Zinc; catalytic"; /evidence="ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:4621826, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942"; METAL 96; /note="Zinc; catalytic"; /evidence="ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942"; METAL 119; /note="Zinc; catalytic"; /evidence="ECO:0000269|PubMed:11076507, ECO:0000269|PubMed:12499545, ECO:0000269|PubMed:1336460, ECO:0000269|PubMed:1433293, ECO:0000269|PubMed:1909891, ECO:0000269|PubMed:19583303, ECO:0000269|PubMed:3151019, ECO:0000269|PubMed:3151020, ECO:0000269|PubMed:7761440, ECO:0000269|PubMed:7803386, ECO:0000269|PubMed:7901850, ECO:0000269|PubMed:8218160, ECO:0000269|PubMed:8262987, ECO:0000269|PubMed:8331673, ECO:0000269|PubMed:8399159, ECO:0000269|PubMed:8431430, ECO:0000269|PubMed:8451242, ECO:0000269|PubMed:8482389, ECO:0000269|PubMed:8639494, ECO:0000269|PubMed:8987974, ECO:0000269|PubMed:9398308, ECO:0000269|PubMed:9865942"
Rhea ID RHEA:10748; RHEA:23056
Cross Reference Brenda 4.2.1.1;