Detail Information for IndEnz0010001748
IED ID IndEnz0010001748
Enzyme Type ID esterase001748
Protein Name Protein phosphatase methylesterase 1
PME-1
EC 3.1.1.89
Gene Name PPE1 CNBH2760
Organism Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Taxonomic Lineage cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)
Enzyme Sequence MSDMFRKSVLNKLPHLPPTRAPWADESEPIEEIDEEDEQLDGIGEFKPATMGPSKHDTQDYSPLSASTFFAQAAEVQPPSTPCTFRVYLTPPNLSIASTNAGTPPGPSGLRTQQQTNRHGTYLVCHHGGGASGLGFAPLAREVKAKGNGEMGVLAFDCRGHGKTSTSDPNLELDLSHDTLLSDFMAIIEMMFPDPKESPSLILLGHSMGAAPVVSAAPELQKKGYTIPGVVVLDVVEGTAVESLPLMKSVLSKRPESFRSVIDAIYWHVTSNSIRNVESARVSVPHIIVPAPSSSSSDPSANPGGKQVWRTNLVGTEPYWEGWYKGLSQRFLRTKCARLLVLAGQERLDRELMVGQMQGKFQLEVMSDVGHYLHEDNPAGLAATLITFWHRNTRVLVLPPKIGAPGPGARGGPVEVKQVGQQ
Enzyme Length 422
Uniprot Accession Number P0CO63
Absorption
Active Site ACT_SITE 207; /evidence=ECO:0000250; ACT_SITE 234; /evidence=ECO:0000250; ACT_SITE 371; /evidence=ECO:0000250
Activity Regulation
Binding Site
Calcium Binding
catalytic Activity CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89;
DNA Binding
EC Number 3.1.1.89
Enzyme Function FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). {ECO:0000250}.
Temperature Dependency
PH Dependency
Pathway
nucleotide Binding
Features Active site (3); Chain (1); Region (1)
Keywords Hydrolase;Serine esterase
Interact With
Induction
Subcellular Location
Modified Residue
Post Translational Modification
Signal Peptide
Structure 3D
Cross Reference PDB -
Mapped Pubmed ID -
Motif
Gene Encoded By
Mass 45,639
Kinetics
Metal Binding
Rhea ID RHEA:48548
Cross Reference Brenda