| IED ID | IndEnz0010001748 |
| Enzyme Type ID | esterase001748 |
| Protein Name |
Protein phosphatase methylesterase 1 PME-1 EC 3.1.1.89 |
| Gene Name | PPE1 CNBH2760 |
| Organism | Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Basidiomycota Agaricomycotina Tremellomycetes Tremellales (jelly fungi) Cryptococcaceae Cryptococcus Cryptococcus neoformans species complex Cryptococcus neoformans (Filobasidiella neoformans) Cryptococcus neoformans var. neoformans Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans) |
| Enzyme Sequence | MSDMFRKSVLNKLPHLPPTRAPWADESEPIEEIDEEDEQLDGIGEFKPATMGPSKHDTQDYSPLSASTFFAQAAEVQPPSTPCTFRVYLTPPNLSIASTNAGTPPGPSGLRTQQQTNRHGTYLVCHHGGGASGLGFAPLAREVKAKGNGEMGVLAFDCRGHGKTSTSDPNLELDLSHDTLLSDFMAIIEMMFPDPKESPSLILLGHSMGAAPVVSAAPELQKKGYTIPGVVVLDVVEGTAVESLPLMKSVLSKRPESFRSVIDAIYWHVTSNSIRNVESARVSVPHIIVPAPSSSSSDPSANPGGKQVWRTNLVGTEPYWEGWYKGLSQRFLRTKCARLLVLAGQERLDRELMVGQMQGKFQLEVMSDVGHYLHEDNPAGLAATLITFWHRNTRVLVLPPKIGAPGPGARGGPVEVKQVGQQ |
| Enzyme Length | 422 |
| Uniprot Accession Number | P0CO63 |
| Absorption | |
| Active Site | ACT_SITE 207; /evidence=ECO:0000250; ACT_SITE 234; /evidence=ECO:0000250; ACT_SITE 371; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=[phosphatase 2A protein]-C-terminal L-leucine methyl ester + H2O = [phosphatase 2A protein]-C-terminal L-leucine + H(+) + methanol; Xref=Rhea:RHEA:48548, Rhea:RHEA-COMP:12134, Rhea:RHEA-COMP:12135, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17790, ChEBI:CHEBI:90516, ChEBI:CHEBI:90517; EC=3.1.1.89; |
| DNA Binding | |
| EC Number | 3.1.1.89 |
| Enzyme Function | FUNCTION: Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). {ECO:0000250}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (3); Chain (1); Region (1) |
| Keywords | Hydrolase;Serine esterase |
| Interact With | |
| Induction | |
| Subcellular Location | |
| Modified Residue | |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 45,639 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | RHEA:48548 |
| Cross Reference Brenda |