| IED ID | IndEnz0010001900 |
| Enzyme Type ID | esterase001900 |
| Protein Name |
Snake venom serine protease Afaacytin alpha/beta/beta' chains SVSP EC 3.4.21.- Fragment |
| Gene Name | |
| Organism | Cerastes cerastes (Horned desert viper) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Metazoa Eumetazoa Bilateria Deuterostomia Chordata Craniata Vertebrata Gnathostomata (jawed vertebrates) Teleostomi Euteleostomi Sarcopterygii Dipnotetrapodomorpha Tetrapoda Amniota Sauropsida Sauria (diapsids) Lepidosauria (lepidosaurs) Squamata (squamates) Bifurcata (split-tongued squamates) Unidentata Episquamata Toxicofera Serpentes (snakes) Colubroidea Viperidae Viperinae (vipers) Cerastes Cerastes cerastes (Horned desert viper) |
| Enzyme Sequence | VIGGAECNINEHRSLVLLYXSSSXFGE |
| Enzyme Length | 27 |
| Uniprot Accession Number | Q9PRM8 |
| Absorption | |
| Active Site | |
| Activity Regulation | ACTIVITY REGULATION: Inhibited by diisopropylfluorophosphate (DFP), benzamidine, heparin and hirudin, but not by plasmatic thrombin inhibitors, antithrombin-III and ecotin. {ECO:0000269|PubMed:8521839}. |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | 3.4.21.- |
| Enzyme Function | FUNCTION: Snake venom serine protease that exhibits alpha-fibrinase and beta-fibrinogenase activities. It replaces missing factors VIII (F8) and IX (F9) in deficient plasmas by activating purified human factor X (F10) into factor Xa. It releases serotonin from platelets and induces platelet aggregation in human (but not in rabbit). Has caseinolytic, arginine-esterase and amidase activities. {ECO:0000269|PubMed:8521839}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Disulfide bond (1); Domain (1); Non-terminal residue (1) |
| Keywords | Blood coagulation cascade activating toxin;Direct protein sequencing;Disulfide bond;Fibrinogenolytic toxin;Fibrinolytic toxin;Glycoprotein;Hemostasis impairing toxin;Hydrolase;Platelet aggregation activating toxin;Protease;Secreted;Serine protease;Toxin |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Both chains alpha and beta are N-glycosylated. |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 2,918 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |