| IED ID | IndEnz0011000183 |
| Enzyme Type ID | glucanase000183 |
| Protein Name |
Beta-glucan synthesis-associated protein KRE6 Killer toxin-resistance protein 6 |
| Gene Name | KRE6 CWH48 YPR159W |
| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Saccharomycetaceae Saccharomyces Saccharomyces cerevisiae (Baker's yeast) Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
| Enzyme Sequence | MPLRNLTETHNFSSTNLDTDGTGDDHDGAPLSSSPSFGQQNDNSTNDNAGLTNPFMGSDEESNARDGESLSSSVHYQPQGSDSSLLHDNSRLDLSQNKGVSDYKGYYSRNNSRAVSTANDNSFLQPPHRAIASSPSLNSNLSKNDILSPPEFDRYPLVGSRVTSMTQLNHHGRSPTSSPGNESSASFSSNPFLGEQDFSPFGGYPASSFPLMIDEKEEDDYLHNPDPEEEARLDRRRFIDDFKYMDKRSASGLAGVLLLFLAAIFIFIVLPALTFTGAIDHESNTEEVTYLTQYQYPQLSAIRTSLVDPDTPDTAKTREAMDGSKWELVFSDEFNAEGRTFYDGDDPYWTAPDVHYDATKDLEWYSPDASTTVNGTLQLRMDAFKNHGLYYRSGMLQSWNKVCFTQGALEISANLPNYGRVSGLWPGLWTMGNLGRPGYLASTQGVWPYSYESCDAGITPNQSSPDGISYLPGQKLSICTCDGEDHPNQGVGRGAPEIDVLEGETDTKIGVGIASQSLQIAPFDIWYMPDYDFIEVYNFTTTTMNTYAGGPFQQAVSAVSTLNVTWYEFGEYGGYFQKYAIEYLNDDDNGYIRWFVGDTPTYTIHAKALHPDGNIGWRRISKEPMSIILNLGISNNWAYIDWQYIFFPVVMSIDYVRIYQPSNAISVTCDPSDYPTYDYIQSHLNAFQNANLTTWEDAGYTFPKNILTGKCTSSKFKLSS |
| Enzyme Length | 720 |
| Uniprot Accession Number | P32486 |
| Absorption | |
| Active Site | |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | |
| DNA Binding | |
| EC Number | |
| Enzyme Function | FUNCTION: Involved in the synthesis of (1->6)- and (1->3)-beta-D-glucan polymers of the yeast cell wall in vivo. It is required for full activity of beta-glucan synthase in vitro. May be involved in the maturation and transport of cell wall proteins (CWP) to the cell wall. May act as a transglucosidase and contribute to the construction of a protein-bound glucan-structure that acts as an acceptor site for the addition of (1->6)-beta-D-glucan at the cell surface. {ECO:0000269|PubMed:10601196, ECO:0000269|PubMed:12237851, ECO:0000269|PubMed:15093776}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Chain (1); Compositional bias (3); Domain (1); Glycosylation (5); Modified residue (6); Region (3); Sequence conflict (4); Topological domain (2); Transmembrane (1) |
| Keywords | Cell wall biogenesis/degradation;Glycoprotein;Golgi apparatus;Membrane;Phosphoprotein;Reference proteome;Signal-anchor;Transmembrane;Transmembrane helix |
| Interact With | |
| Induction | |
| Subcellular Location | SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12237851}; Single-pass type II membrane protein {ECO:0000269|PubMed:12237851}. |
| Modified Residue | MOD_RES 81; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198"; MOD_RES 116; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198"; MOD_RES 133; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198"; MOD_RES 134; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:19779198"; MOD_RES 136; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198"; MOD_RES 139; /note="Phosphoserine"; /evidence="ECO:0007744|PubMed:19779198" |
| Post Translational Modification | |
| Signal Peptide | |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | 10688190; 11805837; 12271460; 12827498; 12878605; 14690591; 15299026; 16429126; 16498706; 16760306; 17107617; 17651441; 18323404; 18508919; 19015325; 19429545; 19841731; 19882662; 19891730; 20489023; 21193403; 2186051; 22174182; 22447934; 23135325; 23148020; 23419716; 23959528; 25710965; 25916991; 26549048; 27260961; 27693354; 27859907; 7565410; 7992502; 8321211; 9335584; 9763440; 9819425; |
| Motif | |
| Gene Encoded By | |
| Mass | 80,123 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |