| IED ID | IndEnz0011000277 |
| Enzyme Type ID | glucanase000277 |
| Protein Name |
Glucan 1,3-beta-glucosidase 2 EC 3.2.1.58 Exo-1,3-beta-glucanase 2 |
| Gene Name | EXG2 CAALFM_C102630CA CaO19.10469 CaO19.2952 |
| Organism | Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Taxonomic Lineage | cellular organisms Eukaryota Opisthokonta Fungi Dikarya Ascomycota saccharomyceta Saccharomycotina (true yeasts) Saccharomycetes Saccharomycetales Debaryomycetaceae Candida/Lodderomyces clade Candida Candida albicans (Yeast) Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
| Enzyme Sequence | MMLFLIHLMALCCMFVAEVACEQFNSTSNSSSAQSSLIDFQYKGVSIGGWLVLEPYITPSLFNATLSSGETWTDLPVDEYHFCEKLGAKEAEKRLTDHWESMYNETDFKQIKEAGLNMVRIPIGYWSFEKLEGDPYVSGAQDYLDKAIEWSHANDLKVMIDLHGAPNTQNGFDNSGLRNLGYPGWQNKTEYVNHTYKVLQQMFQKYGTGKYASDYKNTIIGIEVLNEPLNPNMDKLKEFYIESYNDGREIQVINNTIFFQEAFQPIGYWDSFLEKGEIKVTETSNGTNHTTTKKADFKNIIIDHHHYEVFTESQVASNVSTHLENIKNYASAIGKEKAKAIVGEWSAALTDCAPWLNGVGLGSRYEGTAPYTNDRVGSCAEFNKSPDKWSKKQKKDYRRFVEMQLYEYSTNSQGWIFWCWKTEGATEWDFRALVKNGIMPQPLDNYKYVKNGTDTSSASAIASNKMTLLLAFLLVILVI |
| Enzyme Length | 479 |
| Uniprot Accession Number | Q5AIA1 |
| Absorption | |
| Active Site | ACT_SITE 227; /note=Proton donor; /evidence=ECO:0000250; ACT_SITE 306; /note=Nucleophile; /evidence=ECO:0000250 |
| Activity Regulation | |
| Binding Site | |
| Calcium Binding | |
| catalytic Activity | CATALYTIC ACTIVITY: Reaction=Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose.; EC=3.2.1.58; |
| DNA Binding | |
| EC Number | 3.2.1.58 |
| Enzyme Function | FUNCTION: Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. EXG2 is not heavily involved in the exoglucanase function of the adhesion process. {ECO:0000269|PubMed:21713010}. |
| Temperature Dependency | |
| PH Dependency | |
| Pathway | |
| nucleotide Binding | |
| Features | Active site (2); Chain (1); Glycosylation (11); Lipidation (1); Propeptide (1); Signal peptide (1) |
| Keywords | Cell membrane;Cell wall biogenesis/degradation;GPI-anchor;Glycoprotein;Glycosidase;Hydrolase;Lipoprotein;Membrane;Reference proteome;Secreted;Signal |
| Interact With | |
| Induction | INDUCTION: Induced during cell wall regeneration and repressed by HAP43. {ECO:0000269|PubMed:16455273, ECO:0000269|PubMed:21592964}. |
| Subcellular Location | SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. |
| Modified Residue | |
| Post Translational Modification | PTM: Predicted to be a substrate for cleavage by KEX2. |
| Signal Peptide | SIGNAL 1..21; /evidence=ECO:0000255 |
| Structure 3D | |
| Cross Reference PDB | - |
| Mapped Pubmed ID | - |
| Motif | |
| Gene Encoded By | |
| Mass | 54,534 |
| Kinetics | |
| Metal Binding | |
| Rhea ID | |
| Cross Reference Brenda |